ID  P46061;
PN  Ran GTPase-activating protein 1;
GN  Rangap1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:26506250, ECO:0000269|PubMed:9442102, ECO:0000269|PubMed:9456312}. Nucleus, nucleoplasm {ECO:0000269|PubMed:26506250}. Nucleus envelope {ECO:0000269|PubMed:16469311, ECO:0000269|PubMed:18305100, ECO:0000269|PubMed:26506250, ECO:0000269|PubMed:9442102, ECO:0000269|PubMed:9456312}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P46060}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P46060}. Note=Cytoplasmic during interphase (PubMed:26506250). Detected at the nuclear envelope during interphase (PubMed:9442102, PubMed:9456312, PubMed:26506250). Shuttles between nucleus and cytoplasm (PubMed:26506250). Targeted to the nuclear pores after sumoylation. During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation (By similarity). {ECO:0000250|UniProtKB:P46060, ECO:0000269|PubMed:26506250, ECO:0000269|PubMed:9442102, ECO:0000269|PubMed:9456312}.
DR  UNIPROT: P46061;
DR  UNIPROT: Q60801;
DR  UNIPROT: Q6NZB5;
DR  PDB: 1KPS;
DR  Pfam: PF13516;
DR  Pfam: PF07834;
DE  Function: GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:18305100). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (By similarity). Required for postimplantation embryonic development (PubMed:8314081). {ECO:0000250|UniProtKB:P46060, ECO:0000269|PubMed:18305100, ECO:0000269|PubMed:8314081}.
DE  Reference Proteome: Yes;
DE  Interaction: P35922; IntAct: EBI-16728828; Score: 0.35
DE  Interaction: P63279; IntAct: EBI-1033068; Score: 0.44
DE  Interaction: Q80Z64; IntAct: EBI-8820601; Score: 0.35
DE  Interaction: P52927; IntAct: EBI-9986179; Score: 0.35
DE  Interaction: Q61584; IntAct: EBI-16729686; Score: 0.35
DE  Interaction: Q9EPK7; IntAct: EBI-17172030; Score: 0.35
DE  Interaction: Q8VI24; IntAct: EBI-26885104; Score: 0.35
GO  GO:0016235;
GO  GO:1904115;
GO  GO:0005737;
GO  GO:1990723;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0043231;
GO  GO:0000776;
GO  GO:0072686;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044614;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0106068;
GO  GO:0005096;
GO  GO:0003723;
GO  GO:0031267;
GO  GO:0031625;
GO  GO:0090630;
GO  GO:0071375;
GO  GO:1904117;
GO  GO:0046826;
GO  GO:0051168;
GO  GO:0006913;
GO  GO:0016925;
GO  GO:0048678;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MASEDIAKLAETLAKTQVAGGQLSFKGKGLKLNTAEDAKDVIKEIEEFDGLEALRLEGNTVGVEAARVIAKALEKKSELK
SQ  RCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGK
SQ  ILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRV
SQ  INLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVADK
SQ  AELEKLDLNGNALGEEGCEQLQEVMDSFNMAKVLASLSDDEGEDEDEEEEGEEDDEEEEDEEDEEDDDEEEEEQEEEEEP
SQ  PQRGSGEEPATPSRKILDPNSGEPAPVLSSPTPTDLSTFLSFPSPEKLLRLGPKVSVLIVQQTDTSDPEKVVSAFLKVAS
SQ  VFRDDASVKTAVLDAIDALMKKAFSCSSFNSNTFLTRLLIHMGLLKSEDKIKAIPSLHGPLMVLNHVVRQDYFPKALAPL
SQ  LLAFVTKPNGALETCSFARHNLLQTLYNI
//