ID  P46673;
PN  Nucleoporin NUP85;
GN  NUP85;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: P46673;
DR  UNIPROT: D6VWL3;
DR  PDB: 3EWE;
DR  PDB: 3F3F;
DR  PDB: 3F3G;
DR  PDB: 3F3P;
DR  PDB: 4XMM;
DR  PDB: 4XMN;
DR  PDB: 6X08;
DR  PDB: 7N84;
DR  PDB: 7N9F;
DR  Pfam: PF07575;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization. {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11071906, ECO:0000269|PubMed:11823431, ECO:0000269|PubMed:12543930, ECO:0000269|PubMed:12730220, ECO:0000269|PubMed:8816998, ECO:0000269|PubMed:9774696}.
DE  Reference Proteome: Yes;
DE  Interaction: P32499; IntAct: EBI-1270055; Score: 0.00
DE  Interaction: P35729; IntAct: EBI-4325415; Score: 0.95
DE  Interaction: P36161; IntAct: EBI-295762; Score: 0.55
DE  Interaction: P40368; IntAct: EBI-11889278; Score: 0.55
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P51862; IntAct: EBI-788341; Score: 0.35
DE  Interaction: P49687; IntAct: EBI-797641; Score: 0.92
DE  Interaction: P52891; IntAct: EBI-800196; Score: 0.73
DE  Interaction: Q04491; IntAct: EBI-812133; Score: 0.53
DE  Interaction: P32582; IntAct: EBI-815440; Score: 0.27
DE  Interaction: Q07622; IntAct: EBI-817474; Score: 0.27
DE  Interaction: Q99257; IntAct: EBI-8435423; Score: 0.44
DE  Interaction: Q02630; IntAct: EBI-11889546; Score: 0.59
DE  Interaction: Q02629; IntAct: EBI-11889530; Score: 0.59
DE  Interaction: P53011; IntAct: EBI-1580856; Score: 0.92
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: Q03790; IntAct: EBI-4325410; Score: 0.37
DE  Interaction: Q05166; IntAct: EBI-4325425; Score: 0.37
DE  Interaction: Q8WUM0; IntAct: EBI-11890201; Score: 0.51
DE  Interaction: Q03648; IntAct: EBI-16274990; Score: 0.35
DE  Interaction: Q08224; IntAct: EBI-16274990; Score: 0.35
DE  Interaction: P41940; IntAct: EBI-16274990; Score: 0.35
DE  Interaction: P16622; IntAct: EBI-16274990; Score: 0.35
DE  Interaction: P21560; IntAct: EBI-16274990; Score: 0.35
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0031080;
GO  GO:0017056;
GO  GO:0006406;
GO  GO:0051664;
GO  GO:0006913;
GO  GO:0045893;
GO  GO:0006606;
GO  GO:0000055;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MTIDDSNRLLMDVDQFDFLDDGTAQLSNNKTDEEEQLYKRDPVSGAILVPMTVNDQPIEKNGDKMPLKFKLGPLSYQNMA
SQ  FITAKDKYKLYPVRIPRLDTSKEFSAYVSGLFEIYRDLGDDRVFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEVFIG
SQ  RVKDQDGRVNRFYELEESLTVLNCLRTMYFILDGQDVEENRSEFIESLLNWINRSDGEPDEEYIEQVFSVKDSTAGKKVF
SQ  ETQYFWKLLNQLVLRGLLSQAIGCIERSDLLPYLSDTCAVSFDAVSDSIELLKQYPKDSSSTFREWKNLVLKLSQAFGSS
SQ  ATDISGELRDYIEDFLLVIGGNQRKILQYSRTWYESFCGFLLYYIPSLELSAEYLQMSLEANVVDITNDWEQPCVDIISG
SQ  KIHSILPVMESLDSCTAAFTAMICEAKGLIENIFEGEKNSDDYSNEDNEMLEDLFSYRNGMASYMLNSFAFELCSLGDKE
SQ  LWPVAIGLIALSATGTRSAKKMVIAELLPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFS
SQ  RAGKYELVKSYSWLLFEASCMEGQKLDDPVLNAIVSKNSPAEDDVIIPQDILDCVVTNSMRQTLAPYAVLSQFYELRDRE
SQ  DWGQALRLLLLLIEFPYLPKHYLVLLVAKFLYPIFLLDDKKLMDEDSVATVIEVIETKWDDADEKSSNLYETIIEADKSL
SQ  PSSMATLLKNLRKKLNFKLCQAFM
//