ID  P46892;
PN  Cyclin-dependent kinase 11B;
GN  Cdk11b;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cytoplasm, perinuclear region.
DR  UNIPROT: P46892;
DR  Pfam: PF00069;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DE  Function: Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity- dependent manner. May act as a negative regulator of normal cell cycle progression. {ECO:0000250|UniProtKB:P21127}.
DE  Reference Proteome: Yes;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0004693;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0001824;
GO  GO:0007049;
GO  GO:2001234;
GO  GO:0006468;
GO  GO:0001558;
GO  GO:0007346;
GO  GO:0007088;
GO  GO:0050684;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MKSEKSRTTSWLFQSHEVTEILGRVKKNRKKLVKGLHRAGPPPEKNYLPDSPALSPIELKQELPKYLPALQGCRSVEEFQ
SQ  CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPLTSIREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV
SQ  EHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLTHAGILKVGDFGLAREYGSPLKAYTPVVV
SQ  TLWYRAPELLLGAKEYSTACDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDIGTPSEKIWPGYSELPAVKKMTFSEL
SQ  PYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQCVKRGTSPKPPEGG
SQ  LGYSQLGDDDLKETGFHLTTTNDGAVSCRPWCSLLF
//