ID  P47054;
PN  Nucleoporin NUP192;
GN  NUP192;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Note=Cytoplasmic and nucleoplasmic side of the nuclear pore complex in the nuclear envelope (symmetric distribution).
DR  UNIPROT: P47054;
DR  UNIPROT: D6VWE4;
DR  PDB: 4IFQ;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF11894;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs. {ECO:0000269|PubMed:10428845, ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11121302}.
DE  Reference Proteome: Yes;
DE  Interaction: P32499; IntAct: EBI-6322512; Score: 0.00
DE  Interaction: P34077; IntAct: EBI-789044; Score: 0.55
DE  Interaction: P35729; IntAct: EBI-11888914; Score: 0.37
DE  Interaction: P40066; IntAct: EBI-813993; Score: 0.27
DE  Interaction: P40069; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P23641; IntAct: EBI-787315; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P38708; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P02557; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P09733; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P00359; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-809765; Score: 0.53
DE  Interaction: P41940; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P00330; IntAct: EBI-809765; Score: 0.35
DE  Interaction: P38737; IntAct: EBI-814203; Score: 0.27
DE  Interaction: Q06625; IntAct: EBI-818204; Score: 0.27
DE  Interaction: P43587; IntAct: EBI-853569; Score: 0.35
DE  Interaction: P47087; IntAct: EBI-854119; Score: 0.35
DE  Interaction: P23291; IntAct: EBI-2614250; Score: 0.35
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: P32472; IntAct: EBI-2883301; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P10591; IntAct: EBI-3772666; Score: 0.35
DE  Interaction: P38788; IntAct: EBI-3790799; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3799861; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3806444; Score: 0.35
DE  Interaction: P02829; IntAct: EBI-3812951; Score: 0.35
DE  Interaction: Q12329; IntAct: EBI-3829248; Score: 0.35
DE  Interaction: Q05166; IntAct: EBI-4392356; Score: 0.55
DE  Interaction: Q02630; IntAct: EBI-11888348; Score: 0.59
DE  Interaction: P49687; IntAct: EBI-11888900; Score: 0.59
DE  Interaction: Q03790; IntAct: EBI-11889050; Score: 0.37
DE  Interaction: P38346; IntAct: EBI-16252276; Score: 0.00
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0044611;
GO  GO:0005634;
GO  GO:0017056;
GO  GO:0051028;
GO  GO:0006999;
GO  GO:0006913;
GO  GO:0015031;
GO  GO:0046822;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKNNASRSQLEKGEIELSDGSTFKVNQEFIFEAISLSDE
SQ  LNLDEIVACELILSGDTTANNGKVQYFLRRQYILQIVSFIVNCFHEDTELYQELIKNGALVSNILSAFKFIHTQLSEIKQ
SQ  QINKAQILENYNALFQQNIKFRRDFLLREYDILSQILYGLVDKGAIMKNKDFILSLLHHVSELDSNDFFIIYYTPAFFHL
SQ  FASLRVLPDADVKLLHSQFMKDLKDDSIYTKPVKVALIFIFFAYFIGWCKEDPKRRADTMDFKTDVDEPMTSAVELGAIE
SQ  QILIFAADTSIVEQDKSMELFYDIRSLLERHIPRLIPKQLLDDEKIFSQTTNSTYNPASATDNMSGRGLWNPSYPGMMST
SQ  TGTARLNSMPNNVNEYSYTTIVLSDQTQEFFLSSFDDVLQTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISLKADLER
SQ  FFLSIYFFYASRPEYSCTFWSDKESNAYGFIEWCSRCNDNLMRSCFYLMVSSLSFGPENALNVYHYFGENSSISWKNIAQ
SQ  CLSDYTKKISNFNSSLHKRQQFSESTHNDIDSTAVALEEGLNEEAVIFLSSLLTLVGSVTYQVDEDVKSSLSKVFSDVLF
SQ  EFTKINTPLVGAAFKVISNLVPKLESSRTKFWSFLDSLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIH
SQ  SRENNSEYMVFGKLAFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLPILKIIYTGLCSFDYSVILNSI
SQ  PAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSIFNVVDVGVDQLSIELEGGKNQAELLQLAVKIINKVLDYQE
SQ  TYVEELFPIVKKHGKTDYFLPKNYSLHGLRSFYDAIFFNIPLVAHLGLYVGVDDQILATNSLRILAKLSERSNGSVASLS
SQ  KRNKLLTIFDSVDESARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTISHLLLGFQVSNVISLGPNLAT
SQ  FISSGTSLLDSLISVLEASLNSITKDNIDYAPMRLATAALEIILKLCRNPLTSGLLYSYLIKENFFERIMILDPQVTRFT
SQ  TWNGSPFDNSTEEKCKNFIESESVGAFLSFLAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLDP
SQ  LNYGNICEPKETLSIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSNSFSLTVSKEQFLKDADVECI
SQ  KAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLEPSTRSNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFL
SQ  FDIYNRDRKLITDKGTVDGRLYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSEKVLQDLRLGSKKLVEI
SQ  IWNDVVYGEGTSRVTGILLLDSLIQLANRSKENFILDSLMKTTRLLLIIRSLKNTDALLNSTTEHINIDDLLYELTAFKA
SQ  TVFFLIRVAETRGGASALIENNLFRIIAELSFLKVDPDLGLDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFEL
SQ  IVPIFQLISAVLVSMGSSNKAVVQTVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVKLIVMLCTLTGYQ
SQ  NND
//