ID  P47069;
PN  Spindle pole body assembly component MPS3;
GN  MPS3;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:15282802, ECO:0000269|PubMed:21518795, ECO:0000269|PubMed:22017544, ECO:0000269|PubMed:30141044, ECO:0000269|PubMed:30417519, ECO:0000269|PubMed:34586062}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:12486115, ECO:0000269|PubMed:12493774, ECO:0000269|PubMed:15282802, ECO:0000269|PubMed:22017544, ECO:0000269|PubMed:30141044}. Chromosome, telomere {ECO:0000269|PubMed:32967926}. Note=Localizes to the spindle pole body half bridge throughout the cell cycle (PubMed:15282802). Relocalizes from the spindle pole body to the nuclear envelope in meiosis, via the interaction with HTZ1 (PubMed:22017544, PubMed:21518795). The cohesin component REC8 promotes localization on nuclear envelope in mitotic cells (PubMed:30417519). {ECO:0000269|PubMed:15282802, ECO:0000269|PubMed:21518795, ECO:0000269|PubMed:22017544, ECO:0000269|PubMed:30417519}.
DR  UNIPROT: P47069;
DR  UNIPROT: D6VWG1;
DR  UNIPROT: P47070;
DR  PROSITE: PS51469;
DE  Function: Component of the linker nucleocytoskeleton and cytoskeleton (LINC) complex that regulates telomere movement and meiotic recombination during meiosis (PubMed:17245108, PubMed:18585352, PubMed:32967926). Connects the spindle pole body with the nuclear envelope through its interaction with MPS2 and mediates meiotic bouquet formation and rapid chromosome movements in meiotic prophase (PubMed:16923827, PubMed:17495028, PubMed:22017544). Functions as an integral membrane anchor for telomeres and is a nuclear receptor for the SIR4 pathway of telomere tethering and gene inactivation (PubMed:18039933, PubMed:19390087). Essential for nuclear division and fusion and required for the first step of spindle pole body duplication in G1 (PubMed:12486115, PubMed:12493774). Functions in sister chromatid cohesion establishment (PubMed:15355977, PubMed:16682351). Recruits double-strand breaks (DSBs) to the nuclear periphery for chromosome healing (PubMed:19390086, PubMed:19217407, PubMed:20016273). {ECO:0000269|PubMed:12486115, ECO:0000269|PubMed:12493774, ECO:0000269|PubMed:15355977, ECO:0000269|PubMed:16682351, ECO:0000269|PubMed:16923827, ECO:0000269|PubMed:17245108, ECO:0000269|PubMed:17495028, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18585352, ECO:0000269|PubMed:19217407, ECO:0000269|PubMed:19390086, ECO:0000269|PubMed:19390087, ECO:0000269|PubMed:20016273, ECO:0000269|PubMed:22017544, ECO:0000269|PubMed:32967926}.
DE  Reference Proteome: Yes;
DE  Interaction: P06704; IntAct: EBI-2212835; Score: 0.59
DE  Interaction: P40358; IntAct: EBI-1560984; Score: 0.51
DE  Interaction: P17214; IntAct: EBI-390285; Score: 0.57
DE  Interaction: Q12692; IntAct: EBI-390480; Score: 0.67
DE  Interaction: P40857; IntAct: EBI-856594; Score: 0.00
DE  Interaction: P47007; IntAct: EBI-861529; Score: 0.00
DE  Interaction: P43605; IntAct: EBI-1553262; Score: 0.68
DE  Interaction: Q08955; IntAct: EBI-1795681; Score: 0.50
DE  Interaction: Q12366; IntAct: EBI-1795681; Score: 0.50
DE  Interaction: P53159; IntAct: EBI-2212852; Score: 0.59
DE  Interaction: Q06616; IntAct: EBI-2342813; Score: 0.37
DE  Interaction: P32562; IntAct: EBI-2342907; Score: 0.37
DE  Interaction: P47069; IntAct: EBI-2343343; Score: 0.37
DE  Interaction: Q03362; IntAct: EBI-2343676; Score: 0.37
DE  Interaction: P28791; IntAct: EBI-2344047; Score: 0.37
DE  Interaction: P40504; IntAct: EBI-2344203; Score: 0.37
DE  Interaction: P40348; IntAct: EBI-2346227; Score: 0.37
DE  Interaction: Q12743; IntAct: EBI-2347098; Score: 0.37
DE  Interaction: P53966; IntAct: EBI-2347429; Score: 0.37
DE  Interaction: Q12404; IntAct: EBI-2347465; Score: 0.37
DE  Interaction: P06197; IntAct: EBI-2347992; Score: 0.37
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P52919; IntAct: EBI-7042905; Score: 0.35
DE  Interaction: P36049; IntAct: EBI-7064638; Score: 0.60
DE  Interaction: Q08746; IntAct: EBI-7064638; Score: 0.57
DE  Interaction: Q02199; IntAct: EBI-7064868; Score: 0.27
GO  GO:0000781;
GO  GO:0005737;
GO  GO:0005825;
GO  GO:0016021;
GO  GO:0005639;
GO  GO:0034993;
GO  GO:0005635;
GO  GO:0034399;
GO  GO:0005816;
GO  GO:0005524;
GO  GO:0043495;
GO  GO:0034087;
GO  GO:0007129;
GO  GO:0000741;
GO  GO:0045141;
GO  GO:0007064;
GO  GO:0006998;
GO  GO:0000743;
GO  GO:0030474;
GO  GO:0031509;
GO  GO:0034398;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MNNSNEHRREEAGAANEQMPYNKAVKSAYADVLKDKMNREQEISLRAIKKGIYTDGGETDNYDMDKENDSAYEMFKKNLD
SQ  FPLDQHNDDDDDDPYIEDNGQETDGYSDEDYTDEADKSFIEDSDSDSYDLESNSDFEENLESSGEAKKLKWRTYIFYGGL
SQ  FFVFYFFGSFLMTTVKNNDLESHSSGATSSPGKSFSNLQKQVNHLYSELSKRDEKHSSELDKTVKIIVSQFEKNIKRLLP
SQ  SNLVNFENDINSLTKQVETISTSMSELQRRNHKFTVENVTQWQDQLVKQLDTHLPQEIPVVINNSSSLLIIPELHNYLSA
SQ  LISDVIESPGIGTAGSAESRWEYDLNRYVKEILSNELQYIDKDYFIQEMNRRLQSNKQEIWEEITNRLETQQQQQQQQVQ
SQ  QDYSNVPQQYSSILMKRLIHQIYNSNQHQWEDDLDFATYVQGTKLLNHLTSPTWRQGSGVQPIELLTDSKQSSSTYWQCE
SQ  NEPGCSWAIRFKTPLYLTKISYMHGRFTNNLHIMNSAPRLISLYVKLSQTKEIKALQTLANQYGFGQHHKRDRNYIKIAK
SQ  FEYRLTDSRIRQQMYLPPWFIQLKPLVRSIVFQVDENYGNKKFISLRKFIINGVTPQDLQIIENNEFPVLLGDTPEYGVT
SQ  QNTDEGKRKVLLSKPPYASSSTSTKFHPASNVPSFGQDELDQ
//