ID  P47713;
PN  Lysophospholipase;
GN  Pla2g4a;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:P47712}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P47712}. Nucleus envelope {ECO:0000250|UniProtKB:P47712}. Note=Translocates to intracellular membranes in a calcium-dependent way. {ECO:0000250|UniProtKB:P47712}.
DR  UNIPROT: P47713;
DR  Pfam: PF00168;
DR  Pfam: PF01735;
DR  PROSITE: PS50004;
DR  PROSITE: PS51210;
DE  Function: Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:1904318, PubMed:9403692, PubMed:9403693). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (PubMed:9403692, PubMed:9403693). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity). {ECO:0000250|UniProtKB:P47712, ECO:0000269|PubMed:1904318, ECO:0000269|PubMed:9403692, ECO:0000269|PubMed:9403693}.
DE  Reference Proteome: Yes;
DE  Interaction: P35438; IntAct: EBI-396959; Score: 0.46
DE  Interaction: P51807; IntAct: EBI-657945; Score: 0.37
DE  Interaction: O08709; IntAct: EBI-657956; Score: 0.37
DE  Interaction: P37040; IntAct: EBI-657998; Score: 0.37
DE  Interaction: P70670; IntAct: EBI-658008; Score: 0.37
DE  Interaction: Q91Y86; IntAct: EBI-658048; Score: 0.37
DE  Interaction: Q99K43; IntAct: EBI-658119; Score: 0.37
DE  Interaction: Q9D8F3; IntAct: EBI-658210; Score: 0.37
DE  Interaction: Q99P91; IntAct: EBI-658221; Score: 0.37
DE  Interaction: Q9EQS3; IntAct: EBI-658881; Score: 0.37
DE  Interaction: O89032; IntAct: EBI-658577; Score: 0.37
DE  Interaction: Q6P542; IntAct: EBI-6909752; Score: 0.35
DE  Interaction: A0A0F6B5H5; IntAct: EBI-27035347; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0043231;
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0042588;
GO  GO:0005509;
GO  GO:0047498;
GO  GO:0005544;
GO  GO:0047499;
GO  GO:1902387;
GO  GO:0035035;
GO  GO:0004622;
GO  GO:0008374;
GO  GO:0102545;
GO  GO:0032266;
GO  GO:0070273;
GO  GO:0010314;
GO  GO:0004623;
GO  GO:0019369;
GO  GO:0050482;
GO  GO:0071236;
GO  GO:0046697;
GO  GO:0051649;
GO  GO:0006071;
GO  GO:0046475;
GO  GO:0046456;
GO  GO:0019370;
GO  GO:0006640;
GO  GO:0001542;
GO  GO:0036151;
GO  GO:0034638;
GO  GO:0034478;
GO  GO:0006663;
GO  GO:0043065;
GO  GO:0008284;
GO  GO:0050729;
GO  GO:0043032;
GO  GO:0010572;
GO  GO:0031394;
GO  GO:0032308;
GO  GO:0002827;
GO  GO:0031340;
GO  GO:0001516;
GO  GO:0042127;
GO  GO:0051592;
GO  GO:0010033;
GO  GO:0043129;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILD
SQ  PNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQ
SQ  RKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSH
SQ  PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSMTLSSLKEKVN
SQ  AARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSIL
SQ  FNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQASWVHRMLMALVSDSALFN
SQ  TREGRAGKVHNFMLGLNLNTSYPLSPLRDFSSQDSFDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLI
SQ  LRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFV
SQ  LANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQ
SQ  NPSRCSVSLSNVEARKFFNKEFLSKPTV
//