ID  P48820;
PN  E3 SUMO-protein ligase RanBP2;
GN  RANBP2;
OS  9913;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:P49792}. Nucleus membrane {ECO:0000250|UniProtKB:P49792}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P49792}. Nucleus envelope {ECO:0000250|UniProtKB:P49792}. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments. {ECO:0000250|UniProtKB:P49792}.
DR  UNIPROT: P48820;
DR  UNIPROT: Q28091;
DR  Pfam: PF12185;
DR  Pfam: PF00160;
DR  Pfam: PF00638;
DR  PROSITE: PS00170;
DR  PROSITE: PS50072;
DR  PROSITE: PS50196;
DE  Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin- 1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. {ECO:0000250|UniProtKB:P49792}.
DE  Reference Proteome: Yes;
GO  GO:0005642;
GO  GO:0005635;
GO  GO:0042405;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044615;
GO  GO:0003755;
GO  GO:0003723;
GO  GO:0016740;
GO  GO:0046907;
GO  GO:0051028;
GO  GO:0006457;
GO  GO:0000413;
GO  GO:0016925;
GO  GO:0015031;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  KQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVSDEESKDSRAGATTAADVSGAPNT
SQ  ETTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPGKLNQSGASVGTDE
SQ  DSDVTQEEERDGQHFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDAGQWKERGIGDIKILQNYENKQVRIVMRRD
SQ  QVLKLCANHRITPDMTLQNMKGTERVWVWTACDFADGERKIEHLAVRFKLQDVADSFKKIFDEAKVAQEKDFLITPHVAR
SQ  SATPRESPCGKMAVAVLEETTRERTDLSQGDDAADTTSEVGGVSGTPEPTTKAVVSPPKFVFGSESVKSIFSSEKSKPFA
SQ  FGNSSATGSLFGFSFNTPLKNNSSEASSAAQSGSERKVEPGGRQESQNSDLKSASDGKVKNTSPAFLKEQFSTSHTFKTP
SQ  EKVEERKKPEDLPSDDDVLIVYELTPTPEQRALASRLQLPPTFFCYKNRPDYISEEEEDDEDFDTAVKKLNGKLYLDDSE
SQ  TCRLSEENVTDNEKECVIVWEKKPTVEELAKADTLKLPPTFFCGICSDTDEDNGNAEDFQSELQKVQEAQKSQDENIASS
SQ  ADGMCTDDTKVTVPFLCKSEEPEFTTKSVSSPSVSSGTVDKPVDLSTRKENDADSTSQVESKTVTFGFGSGPGLSFADLA
SQ  SSNSGDFAFGSKDKNFQWANTGAAVFGAQSTSKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAK
SQ  LYRWDREASQWKDRGVGDIKILWHTVKNYFRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQ
SQ  LAVRFKTKEMADCFKKKFEECQQNLLKPQKGQDSLTAEFSKETNPVVFFDICADDEPLGRITMELFSNIVPKTAENFRAL
SQ  CTGEKGFGFKSSIFHRVIPDFVCQGGDITKHDGTGGRSIYGDKFEDENFDVKHTGPGLLSMANRGQDTNNSQFFITLKKA
SQ  ERLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVSRRIIITECGQI
//