ID  P49454;
PN  Centromere protein F;
GN  CENPF;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.
DR  UNIPROT: P49454;
DR  UNIPROT: Q13171;
DR  UNIPROT: Q13246;
DR  UNIPROT: Q5VVM7;
DR  Pfam: PF10490;
DR  Pfam: PF10473;
DR  Pfam: PF10481;
DR  OMIM: 243605;
DR  OMIM: 600236;
DR  DisGeNET: 1063;
DE  Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. {ECO:0000269|PubMed:12974617, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657, ECO:0000269|PubMed:7651420}.
DE  Disease: Stromme syndrome (STROMS) [MIM:243605]: An autosomal recessive congenital disorder characterized by intestinal atresia, ocular anomalies, microcephaly, and renal and cardiac abnormalities in some patients. The disease has features of a ciliopathy, and lethality in early childhood is observed in severe cases. {ECO:0000269|PubMed:25564561, ECO:0000269|PubMed:26820108}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: K9N7C7; IntAct: EBI-26374676; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-25490757; Score: 0.53
DE  Interaction: P43034; IntAct: EBI-2298103; Score: 0.35
DE  Interaction: Q15714; IntAct: EBI-1083967; Score: 0.00
DE  Interaction: Q9GZM8; IntAct: EBI-2295215; Score: 0.75
DE  Interaction: Q8WUM0; IntAct: EBI-7328986; Score: 0.48
DE  Interaction: P57740; IntAct: EBI-7329356; Score: 0.35
DE  Interaction: Q02224; IntAct: EBI-1375056; Score: 0.37
DE  Interaction: P32121; IntAct: EBI-1642843; Score: 0.35
DE  Interaction: Q9NXR1; IntAct: EBI-2298075; Score: 0.40
DE  Interaction: A2AUM9; IntAct: EBI-2563733; Score: 0.40
DE  Interaction: O46385; IntAct: EBI-7872444; Score: 0.37
DE  Interaction: O00257; IntAct: EBI-3951698; Score: 0.35
DE  Interaction: Q7L5N1; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-6515052; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: Q7TSY8; IntAct: EBI-11011396; Score: 0.35
DE  Interaction: Q8BZQ7; IntAct: EBI-11026803; Score: 0.35
DE  Interaction: Q96FF9; IntAct: EBI-11027063; Score: 0.35
DE  Interaction: P63005; IntAct: EBI-11041417; Score: 0.35
DE  Interaction: P70399; IntAct: EBI-11051507; Score: 0.35
DE  Interaction: Q9QYY8; IntAct: EBI-11090422; Score: 0.35
DE  Interaction: Q99PT9; IntAct: EBI-11092405; Score: 0.35
DE  Interaction: P01106; IntAct: EBI-11105437; Score: 0.35
DE  Interaction: Q13283; IntAct: EBI-11106283; Score: 0.35
DE  Interaction: Q08AG7; IntAct: EBI-11108327; Score: 0.35
DE  Interaction: Q8CI51; IntAct: EBI-11124806; Score: 0.35
DE  Interaction: P25963; IntAct: EBI-11133856; Score: 0.35
DE  Interaction: Q9Y253; IntAct: EBI-11141689; Score: 0.35
DE  Interaction: Q71F23; IntAct: EBI-11156542; Score: 0.35
DE  Interaction: Q9UQN3; IntAct: EBI-11510767; Score: 0.37
DE  Interaction: P49356; IntAct: EBI-21502393; Score: 0.35
DE  Interaction: Q96KS9; IntAct: EBI-21503766; Score: 0.35
DE  Interaction: Q8TDR4; IntAct: EBI-21617027; Score: 0.35
DE  Interaction: Q96A37; IntAct: EBI-21627270; Score: 0.35
DE  Interaction: Q9Y2V7; IntAct: EBI-21673529; Score: 0.35
DE  Interaction: Q8N5R6; IntAct: EBI-21699069; Score: 0.35
DE  Interaction: Q9H2F9; IntAct: EBI-21702403; Score: 0.35
DE  Interaction: Q9Y6K9; IntAct: EBI-21708976; Score: 0.35
DE  Interaction: Q9HD26; IntAct: EBI-21720201; Score: 0.35
DE  Interaction: Q96T17; IntAct: EBI-21796065; Score: 0.35
DE  Interaction: Q9UKA1; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q96EY4; IntAct: EBI-21806027; Score: 0.35
DE  Interaction: Q96AP7; IntAct: EBI-21848470; Score: 0.35
DE  Interaction: Q9UPY6; IntAct: EBI-21852540; Score: 0.35
DE  Interaction: Q96JN8; IntAct: EBI-16814395; Score: 0.35
DE  Interaction: P46013; IntAct: EBI-20562326; Score: 0.35
DE  Interaction: P30040; IntAct: EBI-20902848; Score: 0.40
DE  Interaction: Q9BYW2; IntAct: EBI-20911906; Score: 0.40
DE  Interaction: Q02539; IntAct: EBI-20938636; Score: 0.40
DE  Interaction: P14404; IntAct: EBI-21028244; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-21370473; Score: 0.00
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: Q9UM73; IntAct: EBI-32719830; Score: 0.27
DE  Interaction: Q8N612; IntAct: EBI-34574737; Score: 0.27
GO  GO:0005930;
GO  GO:0005813;
GO  GO:0000775;
GO  GO:0036064;
GO  GO:0097539;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0000776;
GO  GO:0030496;
GO  GO:0005635;
GO  GO:0016363;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0000940;
GO  GO:0048471;
GO  GO:0045120;
GO  GO:0005819;
GO  GO:0000922;
GO  GO:0003682;
GO  GO:0140297;
GO  GO:0070840;
GO  GO:0008017;
GO  GO:0008022;
GO  GO:0042803;
GO  GO:0030154;
GO  GO:0051301;
GO  GO:0007059;
GO  GO:0071897;
GO  GO:0001822;
GO  GO:0051382;
GO  GO:0051310;
GO  GO:0000278;
GO  GO:0007094;
GO  GO:0007517;
GO  GO:0045892;
GO  GO:0015031;
GO  GO:0010389;
GO  GO:0016202;
GO  GO:0009410;
GO  GO:0021591;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:10852915};
SQ  MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE
SQ  KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS
SQ  GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD
SQ  FSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL
SQ  QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL
SQ  SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS
SQ  MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV
SQ  ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL
SQ  QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN
SQ  MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI
SQ  IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE
SQ  TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS
SQ  IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS
SQ  QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN
SQ  SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE
SQ  ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS
SQ  TSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGEL
SQ  VEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD
SQ  SLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ
SQ  CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK
SQ  QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE
SQ  TTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPM
SQ  DFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENS
SQ  DLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY
SQ  LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH
SQ  CIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLS
SQ  ESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE
SQ  RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL
SQ  EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCV
SQ  LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNE
SQ  LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLEL
SQ  EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRN
SQ  LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS
SQ  GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQ
SQ  YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIK
SQ  SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM
SQ  LETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKA
SQ  VMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTA
SQ  GGSRSQKVKVAQRSPVDSGTILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ
//