ID  P49790;
PN  Nuclear pore complex protein Nup153;
GN  NUP153;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.
DR  UNIPROT: P49790;
DR  UNIPROT: B4DIK2;
DR  UNIPROT: E7EPX5;
DR  UNIPROT: F6QR24;
DR  UNIPROT: Q4LE47;
DR  UNIPROT: Q5T9I7;
DR  UNIPROT: Q7Z743;
DR  PDB: 2EBQ;
DR  PDB: 2EBR;
DR  PDB: 2EBV;
DR  PDB: 2GQE;
DR  PDB: 4U0C;
DR  PDB: 4U0D;
DR  PDB: 5TSV;
DR  PDB: 5TSX;
DR  PDB: 6AYA;
DR  Pfam: PF08604;
DR  Pfam: PF10599;
DR  Pfam: PF00641;
DR  PROSITE: PS01358;
DR  PROSITE: PS50199;
DR  OMIM: 603948;
DR  DisGeNET: 9972;
DE  Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}. (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}. (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
DE  Reference Proteome: Yes;
DE  Interaction: A8CG34; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: O15504; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P02545; IntAct: EBI-8034338; Score: 0.45
DE  Interaction: P12270; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P35658; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P46060; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9UBU9; IntAct: EBI-7193245; Score: 0.76
DE  Interaction: P29323; IntAct: EBI-7234474; Score: 0.54
DE  Interaction: Q16539; IntAct: EBI-7234526; Score: 0.54
DE  Interaction: P01106; IntAct: EBI-1237540; Score: 0.35
DE  Interaction: Q8WUM0; IntAct: EBI-7329388; Score: 0.53
DE  Interaction: Q8IY92; IntAct: EBI-2371263; Score: 0.35
DE  Interaction: P51784; IntAct: EBI-2511298; Score: 0.40
DE  Interaction: Q9Y2K6; IntAct: EBI-2512022; Score: 0.40
DE  Interaction: Q9QWT9; IntAct: EBI-2558911; Score: 0.40
DE  Interaction: E9PVX6; IntAct: EBI-2561030; Score: 0.40
DE  Interaction: A0A6L7HHZ0; IntAct: EBI-2815987; Score: 0.00
DE  Interaction: A0A6L8PGJ0; IntAct: EBI-2816005; Score: 0.00
DE  Interaction: Q9ZC54; IntAct: EBI-2846253; Score: 0.00
DE  Interaction: P03372; IntAct: EBI-2878124; Score: 0.35
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: P25054; IntAct: EBI-3437314; Score: 0.00
DE  Interaction: Q05322; IntAct: EBI-6159823; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-6515052; Score: 0.35
DE  Interaction: Q96DB2; IntAct: EBI-6598272; Score: 0.35
DE  Interaction: P49790; IntAct: EBI-8232524; Score: 0.60
DE  Interaction: Q8WUF5; IntAct: EBI-9688209; Score: 0.35
DE  Interaction: Q13625; IntAct: EBI-9688225; Score: 0.35
DE  Interaction: P62826; IntAct: EBI-9688194; Score: 0.64
DE  Interaction: P03367; IntAct: EBI-9872771; Score: 0.40
DE  Interaction: O14862; IntAct: EBI-9995694; Score: 0.35
DE  Interaction: P06428; IntAct: EBI-11722493; Score: 0.35
DE  Interaction: Q6PFD9; IntAct: EBI-10994876; Score: 0.35
DE  Interaction: Q8BH74; IntAct: EBI-10997196; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: E9PUA5; IntAct: EBI-10999661; Score: 0.35
DE  Interaction: Q80U93; IntAct: EBI-11014856; Score: 0.35
DE  Interaction: Q8VE37; IntAct: EBI-11043815; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: P18754; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q92973; IntAct: EBI-11076796; Score: 0.53
DE  Interaction: O00629; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8TEM1; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9H9A5; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q53GS7; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P57740; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P78406; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8NFH5; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8IXQ5; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9NXE4; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: J3KMX2; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P52948; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P52292; IntAct: EBI-11076796; Score: 0.53
DE  Interaction: P63165; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9NRG9; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q69YH5; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P61956; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q96HA1; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9UKX7; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P33991; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P62136; IntAct: EBI-11076796; Score: 0.53
DE  Interaction: O14715; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: O00505; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P63279; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9BW27; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q03188; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8NFH4; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P49792; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8NFH3; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q969G3; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: O60684; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: O95373; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q99567; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q86XI6; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9BTX1; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8N1F7; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9HC62; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q96SK2; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P52294; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q8TAQ2; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q96EE3; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q14974; IntAct: EBI-11076796; Score: 0.77
DE  Interaction: Q92621; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9P0U3; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q5SRE5; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q12769; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9BW19; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: E9PF10; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q6NUQ4; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9BPU9; IntAct: EBI-11377507; Score: 0.27
DE  Interaction: Q9GZY0; IntAct: EBI-21528397; Score: 0.35
DE  Interaction: P36873; IntAct: EBI-21564320; Score: 0.35
DE  Interaction: Q9BXS6; IntAct: EBI-21691494; Score: 0.35
DE  Interaction: Q8N9Q2; IntAct: EBI-21723640; Score: 0.35
DE  Interaction: Q2NL82; IntAct: EBI-21815364; Score: 0.35
DE  Interaction: Q9UN86; IntAct: EBI-21866171; Score: 0.35
DE  Interaction: P70168; IntAct: EBI-15732587; Score: 0.52
DE  Interaction: P35408; IntAct: EBI-20811254; Score: 0.37
DE  Interaction: Q9UPY3; IntAct: EBI-20621330; Score: 0.50
DE  Interaction: O96013; IntAct: EBI-26962273; Score: 0.35
DE  Interaction: Q8WVM7; IntAct: EBI-24811291; Score: 0.35
DE  Interaction: Q8N3U4; IntAct: EBI-24811308; Score: 0.35
DE  Interaction: Q8WUY9; IntAct: EBI-25411615; Score: 0.35
DE  Interaction: A0A0H3LH51; IntAct: EBI-25401350; Score: 0.35
DE  Interaction: Q7RTV0; IntAct: EBI-25482472; Score: 0.35
DE  Interaction: P83105; IntAct: EBI-25745135; Score: 0.35
DE  Interaction: Q09161; IntAct: EBI-26396507; Score: 0.35
DE  Interaction: P52298; IntAct: EBI-26397631; Score: 0.35
DE  Interaction: K9N643; IntAct: EBI-26375164; Score: 0.35
DE  Interaction: Q16566; IntAct: EBI-28941485; Score: 0.35
DE  Interaction: Q05D32; IntAct: EBI-27113232; Score: 0.35
DE  Interaction: O15297; IntAct: EBI-27113880; Score: 0.35
DE  Interaction: Q9H9E1; IntAct: EBI-30814700; Score: 0.44
DE  Interaction: Q93009; IntAct: EBI-30841851; Score: 0.44
DE  Interaction: P23771; IntAct: EBI-34580747; Score: 0.35
GO  GO:0005829;
GO  GO:0043657;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0042405;
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0044615;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0003677;
GO  GO:0042802;
GO  GO:0046872;
GO  GO:0008139;
GO  GO:0043495;
GO  GO:0017056;
GO  GO:0051028;
GO  GO:0046832;
GO  GO:0051292;
GO  GO:0006913;
GO  GO:0006606;
GO  GO:0006405;
GO  GO:0046718;
GO  GO:0075732;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPE
SQ  NKEDHLVYADEESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGS
SQ  SGFSLVKEIKDSTSQHDDDNISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLS
SQ  PSLGNSSILKTSQLGDSPFYPGKTTYGGAAAAVRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSS
SQ  PLADAKRIPSIVSSPLNSPLDRSGIDITDFQAKREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRI
SQ  DNKCSTGYEKNMTPGQNREQRESGFSYPNFSLPAANGLSSGVGGGGGKMRRERTRFVASKPLEEEEMEVPVLPKISLPIT
SQ  SSSLPTFNFSSPEITTSSPSPINSSQALTNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPPSSIGFTFSVPVAKTAELS
SQ  GSSSTLEPIISSSAHHVTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPKIDSVAAQPTATSPVVYTRP
SQ  AISSFSSSGIGFGESLKAGSSWQCDTCLLQNKVTDNKCIACQAAKLSPRDTAKQTGIETPNKSGKTTLSASGTGFGDKFK
SQ  PVIGTWDCDTCLVQNKPEAIKCVACETPKPGTCVKRALTLTVVSESAETMTASSSSCTVTTGTLGFGDKFKRPIGSWECS
SQ  VCCVSNNAEDNKCVSCMSEKPGSSVPASSSSTVPVSLPSGGSLGLEKFKKPEGSWDCELCLVQNKADSTKCLACESAKPG
SQ  TKSGFKGFDTSSSSSNSAASSSFKFGVSSSSSGPSQTLTSTGNFKFGDQGGFKIGVSSDSGSINPMSEGFKFSKPIGDFK
SQ  FGVSSESKPEEVKKDSKNDNFKFGLSSGLSNPVSLTPFQFGVSNLGQEEKKEELPKSSSAGFSFGTGVINSTPAPANTIV
SQ  TSENKSSFNLGTIETKSASVAPFTCKTSEAKKEEMPATKGGFSFGNVEPASLPSASVFVLGRTEEKQQEPVTSTSLVFGK
SQ  KADNEEPKCQPVFSFGNSEQTKDENSSKSTFSFSMTKPSEKESEQPAKATFAFGAQTSTTADQGAAKPVFSFLNNSSSSS
SQ  STPATSAGGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLLFSQDSKLATTSSTGTAVTPFVFGPGAS
SQ  SNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPGFGSISSSTALFPTGSQPAPP
SQ  TFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQ
SQ  SPAAFTVGSNGKNVFSSSGTSFSGRKIKTAVRRRK
//