ID  P49792;
PN  E3 SUMO-protein ligase RanBP2;
GN  RANBP2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus {ECO:0000269|PubMed:7775481}. Nucleus membrane {ECO:0000269|PubMed:11839768}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7603572}. Nucleus envelope {ECO:0000269|PubMed:20386726}. Note=Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481). {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:7775481}.
DR  UNIPROT: P49792;
DR  UNIPROT: Q13074;
DR  UNIPROT: Q15280;
DR  UNIPROT: Q53TE2;
DR  UNIPROT: Q59FH7;
DR  PDB: 1RRP;
DR  PDB: 1XKE;
DR  PDB: 1Z5S;
DR  PDB: 2LAS;
DR  PDB: 3UIN;
DR  PDB: 3UIO;
DR  PDB: 3UIP;
DR  PDB: 4GA0;
DR  PDB: 4I9Y;
DR  PDB: 4L6E;
DR  PDB: 4LQW;
DR  PDB: 5CLL;
DR  PDB: 5CLQ;
DR  Pfam: PF12185;
DR  Pfam: PF00160;
DR  Pfam: PF00638;
DR  Pfam: PF00641;
DR  PROSITE: PS00170;
DR  PROSITE: PS50072;
DR  PROSITE: PS50196;
DR  PROSITE: PS50005;
DR  PROSITE: PS50293;
DR  PROSITE: PS01358;
DR  PROSITE: PS50199;
DR  OMIM: 601181;
DR  OMIM: 608033;
DR  DisGeNET: 5903;
DE  Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
DE  Disease: Encephalopathy, acute, infection-induced, 3 (IIAE3) [MIM:608033]: A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem. {ECO:0000269|PubMed:19118815, ECO:0000269|PubMed:34400285}. Note=The disease is caused by variants affecting the gene represented in this entry. Mutations in the RANBP2 gene predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and environmental factors are required (PubMed:19118815). {ECO:0000269|PubMed:19118815}. Note=A chromosomal aberration involving RANBP2 is a cause of chromosome 8p11 myeloproliferative syndrome. Translocation t(2;8)(q12;p11) with FGFR1. Chromosome 8p11 myeloproliferative syndrome is characterized by myeloid hyperplasia, eosinophilia and T-cell or B- cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. {ECO:0000269|PubMed:23041776}.
DE  Reference Proteome: Yes;
DE  Interaction: O14524; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P04626; IntAct: EBI-4373195; Score: 0.46
DE  Interaction: P46060; IntAct: EBI-21928721; Score: 0.62
DE  Interaction: P49790; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: O60260; IntAct: EBI-973169; Score: 0.64
DE  Interaction: P63279; IntAct: EBI-11105225; Score: 0.75
DE  Interaction: P02768; IntAct: EBI-1224020; Score: 0.35
DE  Interaction: P01106; IntAct: EBI-1237540; Score: 0.35
DE  Interaction: P11388; IntAct: EBI-1773456; Score: 0.40
DE  Interaction: Q01320; IntAct: EBI-1775292; Score: 0.40
DE  Interaction: P03116; IntAct: EBI-7414341; Score: 0.40
DE  Interaction: P33176; IntAct: EBI-8602425; Score: 0.40
DE  Interaction: Q9Z0E3; IntAct: EBI-2549710; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-2555617; Score: 0.40
DE  Interaction: Q9QWT9; IntAct: EBI-2558911; Score: 0.40
DE  Interaction: Q07832; IntAct: EBI-2560950; Score: 0.40
DE  Interaction: Q5NET2; IntAct: EBI-2801802; Score: 0.00
DE  Interaction: Q81LI7; IntAct: EBI-2823809; Score: 0.00
DE  Interaction: A0A380PEL1; IntAct: EBI-2841285; Score: 0.00
DE  Interaction: Q0WCK7; IntAct: EBI-2842408; Score: 0.00
DE  Interaction: A0A380PDY1; IntAct: EBI-2856426; Score: 0.00
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: Q9GZQ8; IntAct: EBI-3045543; Score: 0.35
DE  Interaction: P60520; IntAct: EBI-3046676; Score: 0.35
DE  Interaction: P25054; IntAct: EBI-3437454; Score: 0.00
DE  Interaction: Q12802; IntAct: EBI-3449822; Score: 0.00
DE  Interaction: Q4LE39; IntAct: EBI-3449836; Score: 0.00
DE  Interaction: Q9Y613; IntAct: EBI-3449871; Score: 0.00
DE  Interaction: P30533; IntAct: EBI-3449926; Score: 0.00
DE  Interaction: P21675; IntAct: EBI-3450016; Score: 0.00
DE  Interaction: Q96RY7; IntAct: EBI-3450063; Score: 0.00
DE  Interaction: P49792; IntAct: EBI-3450084; Score: 0.00
DE  Interaction: P52292; IntAct: EBI-3931429; Score: 0.37
DE  Interaction: Q13616; IntAct: EBI-3933504; Score: 0.37
DE  Interaction: P62826; IntAct: EBI-3933494; Score: 0.76
DE  Interaction: Q14324; IntAct: EBI-5661299; Score: 0.00
DE  Interaction: Q53GG5; IntAct: EBI-5662564; Score: 0.00
DE  Interaction: O15169; IntAct: EBI-6169699; Score: 0.35
DE  Interaction: P05919; IntAct: EBI-6176256; Score: 0.35
DE  Interaction: Q9UBU9; IntAct: EBI-6262548; Score: 0.53
DE  Interaction: Q9UBE8; IntAct: EBI-6381385; Score: 0.35
DE  Interaction: Q13617; IntAct: EBI-21327106; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-6515052; Score: 0.53
DE  Interaction: Q8WYP5; IntAct: EBI-9050350; Score: 0.40
DE  Interaction: Q13043; IntAct: EBI-10049645; Score: 0.35
DE  Interaction: Q72497; IntAct: EBI-9943756; Score: 0.44
DE  Interaction: Q99853; IntAct: EBI-11317404; Score: 0.35
DE  Interaction: Q12952; IntAct: EBI-11318689; Score: 0.35
DE  Interaction: Q9C009; IntAct: EBI-11319301; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: P03220; IntAct: EBI-11722152; Score: 0.35
DE  Interaction: Q2MG95; IntAct: EBI-11733653; Score: 0.35
DE  Interaction: Q6PFD9; IntAct: EBI-10994876; Score: 0.35
DE  Interaction: Q9Z1B5; IntAct: EBI-10996176; Score: 0.35
DE  Interaction: Q8BH74; IntAct: EBI-10997196; Score: 0.35
DE  Interaction: Q99P88; IntAct: EBI-10997466; Score: 0.35
DE  Interaction: E9PUA5; IntAct: EBI-10999661; Score: 0.35
DE  Interaction: Q80U93; IntAct: EBI-11014856; Score: 0.35
DE  Interaction: Q8VE37; IntAct: EBI-11043815; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: Q9BVL2; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: E9Q3P4; IntAct: EBI-11086604; Score: 0.35
DE  Interaction: Q96EE3; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q14974; IntAct: EBI-11115566; Score: 0.35
DE  Interaction: P57740; IntAct: EBI-11160436; Score: 0.35
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: P18754; IntAct: EBI-21567271; Score: 0.35
DE  Interaction: P61769; IntAct: EBI-21675069; Score: 0.35
DE  Interaction: Q9BXS6; IntAct: EBI-21691494; Score: 0.35
DE  Interaction: Q9Y228; IntAct: EBI-21696444; Score: 0.35
DE  Interaction: Q8IYT4; IntAct: EBI-16421609; Score: 0.35
DE  Interaction: P70168; IntAct: EBI-15732742; Score: 0.36
DE  Interaction: Q921C5; IntAct: EBI-15847872; Score: 0.63
DE  Interaction: Q8TD16; IntAct: EBI-15847951; Score: 0.40
DE  Interaction: Q6ZNJ1; IntAct: EBI-16749633; Score: 0.35
DE  Interaction: Q15628; IntAct: EBI-20737473; Score: 0.35
DE  Interaction: P10809; IntAct: EBI-20901016; Score: 0.40
DE  Interaction: Q8N9W5; IntAct: EBI-20913366; Score: 0.40
DE  Interaction: Q92878; IntAct: EBI-20918244; Score: 0.40
DE  Interaction: Q6P4A8; IntAct: EBI-20931312; Score: 0.40
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q9Y275; IntAct: EBI-21266480; Score: 0.35
DE  Interaction: O00213; IntAct: EBI-21017901; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: O00499; IntAct: EBI-21385533; Score: 0.00
DE  Interaction: Q5NHH2; IntAct: EBI-22299104; Score: 0.37
DE  Interaction: P11234; IntAct: EBI-25376255; Score: 0.35
DE  Interaction: P83105; IntAct: EBI-25745135; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25636144; Score: 0.35
DE  Interaction: Q9Y5P2; IntAct: EBI-26354638; Score: 0.35
DE  Interaction: P42685; IntAct: EBI-28935169; Score: 0.35
DE  Interaction: P53350; IntAct: EBI-28938281; Score: 0.35
DE  Interaction: Q86UX6; IntAct: EBI-28942129; Score: 0.35
DE  Interaction: Q96GD4; IntAct: EBI-28944360; Score: 0.35
DE  Interaction: Q9Y6S9; IntAct: EBI-28948011; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: Q05D32; IntAct: EBI-27113232; Score: 0.35
DE  Interaction: O15297; IntAct: EBI-27113880; Score: 0.35
DE  Interaction: Q13283; IntAct: EBI-28955349; Score: 0.35
DE  Interaction: Q07866; IntAct: EBI-30822114; Score: 0.44
DE  Interaction: P63165; IntAct: EBI-30826718; Score: 0.44
GO  GO:0005642;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0042405;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044614;
GO  GO:0044615;
GO  GO:0005654;
GO  GO:0106068;
GO  GO:0046872;
GO  GO:0003723;
GO  GO:0031267;
GO  GO:0061665;
GO  GO:0019789;
GO  GO:0051642;
GO  GO:0051028;
GO  GO:0006607;
GO  GO:0051168;
GO  GO:0006913;
GO  GO:0033133;
GO  GO:0006457;
GO  GO:0000413;
GO  GO:0016925;
GO  GO:0006111;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLGLLYELEENTDKAV
SQ  ECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYV
SQ  RPDDVHVNIRLVEVYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
SQ  NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHSSNVQWRALSELAALCY
SQ  LIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSF
SQ  LGSDDIGNIDVREPELEDLTRYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
SQ  ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNVAKLRLLVQHEIN
SQ  TLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQA
SQ  SEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
SQ  IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTRYSLSPSKSYKYSPKTP
SQ  PRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQS
SQ  PAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
SQ  YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLPTQAHTTQPTPFKFNSNFKSN
SQ  DGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDGYSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQ
SQ  KNSGFRRSDDMFTFHGPGKSVFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
SQ  LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQ
SQ  LAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAVRIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNS
SQ  CSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
SQ  TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCAACQNPRKQSLPATSIPTPAS
SQ  FKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFE
SQ  GMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
SQ  SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQCPSKQNQTTAIS
SQ  TPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLKCVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTG
SQ  FKSNFSEKASKFGNTEQGFKFGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
SQ  GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDD
SQ  DAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQV
SQ  LKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
SQ  GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDSVSS
SQ  SSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLV
SQ  EVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
SQ  VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERT
SQ  DVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSET
SQ  SSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTP
SQ  TAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTV
SQ  EEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSIT
SQ  KSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVF
SQ  GTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKI
SQ  LWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEEC
SQ  QQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDF
SQ  VCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVK
SQ  KIESFGSPKGSVCRRITITECGQI
//