ID  P50613;
PN  Cyclin-dependent kinase 7;
GN  CDK7;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (PubMed:19071173). {ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}.
DR  UNIPROT: P50613;
DR  UNIPROT: Q9BS60;
DR  UNIPROT: Q9UE19;
DR  PDB: 1UA2;
DR  PDB: 6O9L;
DR  PDB: 6XBZ;
DR  PDB: 6XD3;
DR  PDB: 7B5O;
DR  PDB: 7B5Q;
DR  PDB: 7EGB;
DR  PDB: 7EGC;
DR  PDB: 7ENA;
DR  PDB: 7ENC;
DR  PDB: 7LBM;
DR  PDB: 7NVR;
DR  Pfam: PF00069;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DR  OMIM: 601955;
DR  DisGeNET: 1022;
DE  Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C- terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}.
DE  Reference Proteome: Yes;
DE  Interaction: O15027; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: P11802; IntAct: EBI-15560841; Score: 0.44
DE  Interaction: P12270; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: P51948; IntAct: EBI-1245984; Score: 0.82
DE  Interaction: P51946; IntAct: EBI-1245984; Score: 0.93
DE  Interaction: P32121; IntAct: EBI-1642567; Score: 0.35
DE  Interaction: A0A380PKN3; IntAct: EBI-2873645; Score: 0.00
DE  Interaction: P31016; IntAct: EBI-7960638; Score: 0.44
DE  Interaction: P51659; IntAct: EBI-3906748; Score: 0.37
DE  Interaction: P01909; IntAct: EBI-3906738; Score: 0.37
DE  Interaction: P24941; IntAct: EBI-6255891; Score: 0.71
DE  Interaction: P01023; IntAct: EBI-6380434; Score: 0.35
DE  Interaction: P32780; IntAct: EBI-6380434; Score: 0.76
DE  Interaction: P48740; IntAct: EBI-6380434; Score: 0.35
DE  Interaction: P19447; IntAct: EBI-6380434; Score: 0.74
DE  Interaction: P18074; IntAct: EBI-6380434; Score: 0.74
DE  Interaction: Q92759; IntAct: EBI-6380434; Score: 0.67
DE  Interaction: Q13888; IntAct: EBI-6380434; Score: 0.67
DE  Interaction: P23634; IntAct: EBI-6380434; Score: 0.35
DE  Interaction: P28715; IntAct: EBI-6380434; Score: 0.67
DE  Interaction: Q13889; IntAct: EBI-6380434; Score: 0.67
DE  Interaction: Q6ZYL4; IntAct: EBI-6380434; Score: 0.74
DE  Interaction: P78362; IntAct: EBI-6657590; Score: 0.59
DE  Interaction: Q96SB4; IntAct: EBI-6659767; Score: 0.59
DE  Interaction: P08238; IntAct: EBI-6424069; Score: 0.56
DE  Interaction: Q01094; IntAct: EBI-6599707; Score: 0.27
DE  Interaction: Q6P1K8; IntAct: EBI-21622006; Score: 0.53
DE  Interaction: O96006; IntAct: EBI-21692488; Score: 0.35
DE  Interaction: P14635; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q58FG0; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q9UBF8; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q96NH3; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q8IZL9; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q58FG1; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q58FF7; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q58FF6; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q13451; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: Q13137; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: P46527; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: P24864; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: P20248; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: P07900; IntAct: EBI-21835901; Score: 0.35
DE  Interaction: P06493; IntAct: EBI-15560801; Score: 0.44
DE  Interaction: P24928; IntAct: EBI-15560781; Score: 0.44
DE  Interaction: Q6IAW3; IntAct: EBI-15560872; Score: 0.44
DE  Interaction: Q9BWU1; IntAct: EBI-15560892; Score: 0.44
DE  Interaction: O00267; IntAct: EBI-15560912; Score: 0.44
DE  Interaction: P21127; IntAct: EBI-15560932; Score: 0.44
DE  Interaction: Q9NXF1; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q96PZ0; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8WUA4; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q7Z4V5; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: O15355; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q13042; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8N1G0; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P30260; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q96ME7; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8TDI0; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q7Z5K2; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9NW82; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y3C7; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y2R4; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9UK58; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9NY93; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9NX58; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9NW13; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9NVC6; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9H0A0; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9BZE4; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q96S94; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q92621; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8TF01; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8IY81; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8IX01; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q6PD62; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q16543; IntAct: EBI-16789709; Score: 0.42
DE  Interaction: Q14684; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q14241; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q13823; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q13610; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q13011; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P55199; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P46013; IntAct: EBI-16789709; Score: 0.48
DE  Interaction: P29083; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: O75683; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: O00541; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y5Q9; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y5Q8; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y4W2; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y2X9; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9Y2G7; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9H9Y6; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9H9B1; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9BYE7; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q9BTC8; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q8IWI9; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q6P1X5; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q5UIP0; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q15542; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q13206; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: Q12789; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P62891; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P49848; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P49642; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P38432; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P29084; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P21675; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: O95602; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: O00268; IntAct: EBI-16789709; Score: 0.27
DE  Interaction: P15927; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: P56270; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: P0DMV8; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: Q7Z739; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: Q709F0; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: P62633; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: O15235; IntAct: EBI-16790014; Score: 0.35
DE  Interaction: Q02539; IntAct: EBI-20913302; Score: 0.40
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: Q9Y2W1; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q9UPE1; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q9UHB6; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q9NYF8; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q96SB3; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q8ND56; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q8IUD2; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q86X55; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q16891; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q16643; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: Q01082; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: P54886; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: P11388; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: P0C0S5; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: P04637; IntAct: EBI-28935791; Score: 0.35
DE  Interaction: O00763; IntAct: EBI-28935791; Score: 0.35
GO  GO:0070516;
GO  GO:0019907;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0001650;
GO  GO:0001673;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0000439;
GO  GO:0005675;
GO  GO:0070985;
GO  GO:0005524;
GO  GO:0008094;
GO  GO:0004693;
GO  GO:0008022;
GO  GO:0004672;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0008353;
GO  GO:0007049;
GO  GO:0051301;
GO  GO:0006281;
GO  GO:0070816;
GO  GO:0045944;
GO  GO:0006468;
GO  GO:0050821;
GO  GO:0051726;
GO  GO:0000079;
GO  GO:2000045;
GO  GO:0042795;
GO  GO:0006366;
GO  GO:0006367;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDA
SQ  FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK
SQ  SFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
SQ  CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQ
SQ  SNPALAIKRKRTEALEQGGLPKKLIF
//