ID  P52593;
PN  Nucleoporin NUP188;
GN  NUP188;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: P52593;
DR  UNIPROT: D6W0I1;
DR  PDB: 7N84;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WO9;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF10487;
DR  Pfam: PF18378;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP188 probably plays an important role in NPC assembly and organization. {ECO:0000269|PubMed:10684247}.
DE  Reference Proteome: Yes;
DE  Interaction: P30822; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P34077; IntAct: EBI-4324997; Score: 0.37
DE  Interaction: P40069; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: Q08959; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P38708; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P16140; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P02557; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P09733; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P00359; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-809801; Score: 0.53
DE  Interaction: P10592; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-809801; Score: 0.53
DE  Interaction: P32905; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P05317; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P49626; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P41940; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P23641; IntAct: EBI-809801; Score: 0.35
DE  Interaction: Q12134; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P00549; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P00330; IntAct: EBI-809801; Score: 0.35
DE  Interaction: P53201; IntAct: EBI-853752; Score: 0.35
DE  Interaction: P53877; IntAct: EBI-854143; Score: 0.35
DE  Interaction: P04912; IntAct: EBI-7352971; Score: 0.40
DE  Interaction: Q02486; IntAct: EBI-8221624; Score: 0.22
DE  Interaction: P23291; IntAct: EBI-2614250; Score: 0.35
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P46988; IntAct: EBI-3738147; Score: 0.35
DE  Interaction: Q12329; IntAct: EBI-3750975; Score: 0.35
DE  Interaction: Q06677; IntAct: EBI-3758709; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3799853; Score: 0.35
DE  Interaction: Q02629; IntAct: EBI-11888868; Score: 0.37
DE  Interaction: Q02630; IntAct: EBI-11888884; Score: 0.37
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044611;
GO  GO:0017056;
GO  GO:0031990;
GO  GO:0006999;
GO  GO:0006913;
GO  GO:0006606;
GO  GO:0006405;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MATPSFGNSSPQLTFTHVANFMNDAAADVSAVDAKQLAQIRQFLKANKTNLIESLNTIRQNVTSSGDHNKLRSTIANLLQ
SQ  INVDNDPFFAQSEDLSHAVEFFMSERSSRLHIVYSLLVNPDIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSL
SQ  AHDYNNDQDMFTIVSLVQLKKFSDLKFILQILQILNLMILNTKVPVDIVNQWFLQYQNQFVEFCRNINSTDKSIDTSSLQ
SQ  LYKFQNFQDLSYLSETLISRISSLFTITTILILGLNTSIAQFDIQSPLYMDTETFDTVNSALENDVATNIVNEDPIFHPM
SQ  IHYSWSFILYYRRALQSSESFDDSDITKFALFAESHDVLQKLNTLSEILSFDPVYTTVITVFLEFSLNFIPITASTSRVF
SQ  AKIISKAPEQFIENFLTNDTFEKKLSIIKAKLPLLNESLIPLINLALIDTEFANFELKDICSFAVTKSSLNDLDYDLIAD
SQ  TITNSSSSSDIIVPDLIELKSDLLVAPPLENENSNCLLSIPKSTKGKILTIKQQQQQQQQQNGQQPPTTSNLIIFLYKFN
SQ  GWSLVGRILQNLLHSYMEKGTQLDDLQHELMISIIKLVTNVVDPKTSIEKSSEILSYLSNSLDTSASTINGASIIQVIFE
SQ  IFEISLQRKDYTSIVQCCEFMTMLTPNYLHLVSSYLNKSDLLDKYGKTGLSNMILGSVELSTGDYTFTIQLLKLTKVFIR
SQ  ESLSLKNIHISKRSKIDIINKLILHAIHIFESYYNWKYNNFLQKFEIAFHLTLIFYDVLHDVFTINPHQKDQLIISSSAN
SQ  KLLQLFLTPMDSIDLAPNTLTNILISPLNTTTKILGDKILGNLYSKVMNNSFKLCTLLIAIRGSNRDLKPSNLEKLLFIN
SQ  SSKLVDVYTLPSYVHFKVQIIELLSYLVEAPWNDDYPFLLSFLGEAKSMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLL
SQ  ESKQDGLSILFLTGQFASNKKINDESSIDKKSSILTVLQKNSLLLDSTPEEVSCKLLETITYVLNTWTNSKIFIKDPKFV
SQ  NSLLAKLKDSKKLFQKKENLTRDETVSLIKKYKLISRIVEIFALCIYNSTDSNSEILNFLNQEDLFELVHHFFQIDGFNK
SQ  TFHDELNLKFKEKWPSLELQSFQKIPLSRINENENFGYDIPLLDIVLKADRSWNEPSKSQTNFKEEITDASLNLQYVNYE
SQ  ISTAKAWGALITTFVKRSTVPLNDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFYILYSFKLSGKLLKEEKIIEL
SQ  MNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLELVSSGDRFIELISDQLLEFFELVFSKGVYLILSEILCQIN
SQ  KCSTRGLSTDHTTQIVNLEDNTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLYSSAHLIRINDEPILG
SQ  QITLTFISELCSIEPIAAKLINSGLYSVLLESPLSVAIQQGDIKPEFSPRLHNIWSNGLLSIVLLLLSQFGIKVLPETCL
SQ  FVSYFGKQIKSTIYNWGDNKLAVSSSLIKETNQLVLLQKMLNLLNYQELFIQPKNSDDQQEAVELVIGLDSEHDKKRLSA
SQ  ALSKFLTHPKYLNSRIIPTTLEEQQQLEDESSRLEFVKGISRDIKALQDSLFKDV
//