ID  P53148;
PN  Spindle pole body component SPC105;
GN  SPC105;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Chromosome, centromere, kinetochore. Note=Localizes to the nuclear side of the spindle pole body.
DR  UNIPROT: P53148;
DR  UNIPROT: D6VU52;
DR  PDB: 4BL0;
DR  Pfam: PF18210;
DR  Pfam: PF08317;
DE  Function: Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint. {ECO:0000269|PubMed:19893618}.
DE  Reference Proteome: Yes;
DE  Interaction: P47149; IntAct: EBI-599281; Score: 0.37
DE  Interaction: P14693; IntAct: EBI-855274; Score: 0.00
DE  Interaction: Q04431; IntAct: EBI-7384815; Score: 0.66
DE  Interaction: Q04477; IntAct: EBI-1002308; Score: 0.64
DE  Interaction: P40568; IntAct: EBI-1543715; Score: 0.35
DE  Interaction: Q12143; IntAct: EBI-1543729; Score: 0.35
DE  Interaction: P39731; IntAct: EBI-1543771; Score: 0.35
DE  Interaction: P40460; IntAct: EBI-1543811; Score: 0.50
DE  Interaction: P33895; IntAct: EBI-1543811; Score: 0.35
DE  Interaction: P54199; IntAct: EBI-2612619; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3695987; Score: 0.35
DE  Interaction: P36016; IntAct: EBI-3707979; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3722158; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3729986; Score: 0.35
DE  Interaction: Q06677; IntAct: EBI-3759021; Score: 0.35
GO  GO:0000776;
GO  GO:0005739;
GO  GO:0031617;
GO  GO:0031965;
GO  GO:0005816;
GO  GO:0008017;
GO  GO:0051382;
GO  GO:1990758;
GO  GO:0007094;
GO  GO:0034501;
GO  GO:0031134;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MNVDERSRIGGREKDAGPGKGILKQNQSSQMTSSFLENPGVRIPTRIITKKEVLDGSNTTSRINTSNLQSMVKRRVSFAP
SQ  DVTLHSFTFVPEQNNEIKEPRRRKTSTNSPTKISSQEEPLVTSTQIDDARTEEKTAAEEDPDTSGMELTEPIVATPDSNK
SQ  ASQHDPTSMEMTEVFPRSIRQKNPDVEGESIESSQQIDDVEAVREETMELTAIHNVHDYDSISKDTVEGEPIDLTEYESK
SQ  PYVPNSVSRSTGKSSDYSVERSNDKSDLSKSENKTNSSQPMEITDIFHADPQNPMSLHSDNNINNDGNEMELTQIQTNFD
SQ  RDNHHIDESPSEKHAFSSNKRRKLDTVSDYAASVTTPVKEAKDTSGEDNDGDLEMMEKMSPITFSDVDNKIGTRSNDVFT
SQ  IEPGTEDTGMQTATDDEEDGENVDDNGNKIVEKTRLPEIDKEGQSGIALPTQDYTLREFINEVGVGFLDTKLIDDLDKKV
SQ  NFPLNSFNFVENQRIDNVFSAFYIDIPILEVEAFRCKELWRSINESKDKFKDFEAQIDKSHPPLLLQEYFSSDEKMKQLM
SQ  RDQLQLVKGYSKLEAAMEWYEWRKKQLNGLELILAENLNTLKREYEKLNEEVEKVNSIRGKIRKLNEAIKEEIRSLKNLP
SQ  SDSYKPTLMNRIKIEAFKQELMEHSISLSSSNDFTQEMRSLKLAIAKKSNDILTLRSEVASIDKKIEKRKLFTRFDLPKL
SQ  RDTLKILESLTGVRFLKFSKATLSIAFLQLDDLRVDINLANFKNNPLSSMKVMNDSNNDDMSYHLFTMLLKNVEAEHQDS
SQ  MLSNLFFAMKKWRPLLKYIKLLKLLFPVKITQTEEEEALLQFKDYDRRNKTAFFYVISLVSFAQGVFSENGQIPMKVHIS
SQ  TQQDYSPSREVLSDRITHKISGVLPSFTKSRIHLEFT
//