ID  P53368;
PN  Oxidized purine nucleoside triphosphate hydrolase;
GN  Nudt1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:P53369}. Nucleus {ECO:0000250|UniProtKB:P53369}. Nucleus membrane {ECO:0000250|UniProtKB:P53369}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P53369}.
DR  UNIPROT: P53368;
DR  UNIPROT: P97795;
DR  UNIPROT: Q542J4;
DR  UNIPROT: Q8VDG0;
DR  PDB: 5MZE;
DR  PDB: 5MZG;
DR  PDB: 6EHH;
DR  Pfam: PF00293;
DR  PROSITE: PS51462;
DR  PROSITE: PS00893;
DE  Function: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Has also a significant hydrolase activity toward 2-oxo- ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478, PubMed:32144205). {ECO:0000250|UniProtKB:P36639, ECO:0000269|PubMed:11572992, ECO:0000269|PubMed:29281266, ECO:0000269|PubMed:30304478, ECO:0000269|PubMed:32144205, ECO:0000269|PubMed:7592783}.
DE  Reference Proteome: Yes;
GO  GO:0001669;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005615;
GO  GO:0005759;
GO  GO:0005739;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0106377;
GO  GO:0106378;
GO  GO:0035539;
GO  GO:0008413;
GO  GO:0047693;
GO  GO:0008828;
GO  GO:0016818;
GO  GO:0046872;
GO  GO:0030515;
GO  GO:0007568;
GO  GO:0042262;
GO  GO:0008584;
GO  GO:0006152;
GO  GO:0046686;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELLEESGLSVDTLHKVGHISFEFVGSPEL
SQ  MDVHIFSADHVHGTPTESEEMRPQWFQLDQIPFADLWPDDSYWFPLLLQKKKFCGHFKFQDQDTILSYSLREVDSF
//