ID  P53895;
PN  Protein ASI2;
GN  ASI2;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:17085444}; Multi-pass membrane protein {ECO:0000269|PubMed:17085444}.
DR  UNIPROT: P53895;
DR  UNIPROT: D6W124;
DE  Function: Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748). {ECO:0000269|PubMed:11454748, ECO:0000269|PubMed:17085444, ECO:0000269|PubMed:25236469}.
DE  Reference Proteome: Yes;
DE  Interaction: P38074; IntAct: EBI-855745; Score: 0.00
DE  Interaction: P25294; IntAct: EBI-3762277; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3793098; Score: 0.35
DE  Interaction: P10614; IntAct: EBI-10096421; Score: 0.40
DE  Interaction: P53983; IntAct: EBI-10096480; Score: 0.46
DE  Interaction: P54074; IntAct: EBI-10096457; Score: 0.46
GO  GO:0097658;
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0005637;
GO  GO:0071230;
GO  GO:0036369;
GO  GO:0006511;
TP  Membrane Topology: Transmembrane; Source: UniProt - Curator Inference {ECO:0000305|PubMed:17085444};
SQ  MARPQNHRRSNWTERDDNDDYLFQRFLEESETRHSREPSPVTEQSQQELQQDVQQAIDGIFNSLRRNMSSTSNINRAANM
SQ  DATTNGNGGINADTIRATNANTADSPFTARQQSPLRTFLRNLFILDYFIGLILFPFSVYNILRSGFNSMTFSENDFIIEI
SQ  VGYWKFAKIFGSGGTTLIAYKDTGKLGLLGKFHNIIVFYSSPVIKHIMKSRDGNEPNLNWIRLMFAKAFELFVKVSTILI
SQ  YLAYGVSGTVYMVTAGFFFVLCLLFTVIRRYKGVHRMLVSQRITGPGVF
//