ID  P54313;
PN  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;
GN  Gnb2;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P62879}. Cell membrane {ECO:0000250|UniProtKB:P62879}.
DR  UNIPROT: P54313;
DR  UNIPROT: Q71SU9;
DR  Pfam: PF00400;
DR  PROSITE: PS00678;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DE  Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
DE  Reference Proteome: Yes;
DE  Interaction: P80386; IntAct: EBI-16400563; Score: 0.35
DE  Interaction: Q2Q0I9; IntAct: EBI-15563359; Score: 0.40
DE  Interaction: O75886; IntAct: EBI-22259612; Score: 0.35
DE  Interaction: P98077; IntAct: EBI-22260014; Score: 0.35
DE  Interaction: Q92835; IntAct: EBI-22260917; Score: 0.35
DE  Interaction: Q7M4L6; IntAct: EBI-22260664; Score: 0.35
DE  Interaction: Q13239; IntAct: EBI-22261339; Score: 0.35
DE  Interaction: O15357; IntAct: EBI-22261281; Score: 0.35
DE  Interaction: Q9UGK3; IntAct: EBI-22262317; Score: 0.35
DE  Interaction: P43403; IntAct: EBI-22266118; Score: 0.35
GO  GO:0044297;
GO  GO:0005737;
GO  GO:0005834;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0032991;
GO  GO:0005246;
GO  GO:0051020;
GO  GO:0044877;
GO  GO:0030159;
GO  GO:0007186;
GO  GO:1901379;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI
SQ  IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS
SQ  SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA
SQ  FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGV
SQ  TDDGMAVATGSWDSFLKIWN
//