ID  P57103;
PN  Sodium/calcium exchanger 3;
GN  SLC8A3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:21959935}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P70549}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70549}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P70549}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:S4R2P9}. Cell junction {ECO:0000250|UniProtKB:S4R2P9}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:S4R2P9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21959935}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:21959935}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Note=Detected at neuromuscular junctions. {ECO:0000250|UniProtKB:S4R2P9}.
DR  UNIPROT: P57103;
DR  UNIPROT: Q5K3P6;
DR  UNIPROT: Q5K3P7;
DR  UNIPROT: Q8IUE9;
DR  UNIPROT: Q8IUF0;
DR  UNIPROT: Q8NFI7;
DR  UNIPROT: Q96QG1;
DR  UNIPROT: Q96QG2;
DR  Pfam: PF03160;
DR  Pfam: PF01699;
DR  Pfam: PF16494;
DR  OMIM: 607991;
DR  DisGeNET: 6547;
DE  Function: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}.
DE  Reference Proteome: Yes;
DE  Interaction: P48165; IntAct: EBI-24665899; Score: 0.56
DE  Interaction: Q9H6H4; IntAct: EBI-21868787; Score: 0.35
DE  Interaction: Q9UPR5; IntAct: EBI-21868787; Score: 0.35
DE  Interaction: Q8TCT7; IntAct: EBI-21868787; Score: 0.35
DE  Interaction: Q8N6G5; IntAct: EBI-21868787; Score: 0.35
DE  Interaction: P43304; IntAct: EBI-21868787; Score: 0.35
DE  Interaction: A2A935; IntAct: EBI-21024514; Score: 0.35
GO  GO:0070161;
GO  GO:0030424;
GO  GO:0043679;
GO  GO:0030425;
GO  GO:0043197;
GO  GO:0005789;
GO  GO:0005887;
GO  GO:0031226;
GO  GO:0016020;
GO  GO:0005741;
GO  GO:0031594;
GO  GO:0043025;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0098794;
GO  GO:0014069;
GO  GO:0042383;
GO  GO:0016528;
GO  GO:0045202;
GO  GO:0005432;
GO  GO:0005516;
GO  GO:0099580;
GO  GO:0046872;
GO  GO:0098703;
GO  GO:0070588;
GO  GO:0007154;
GO  GO:0006874;
GO  GO:0071456;
GO  GO:0002244;
GO  GO:0006811;
GO  GO:0007612;
GO  GO:0007611;
GO  GO:0060291;
GO  GO:0007613;
GO  GO:0030001;
GO  GO:0051560;
GO  GO:0006851;
GO  GO:0098815;
GO  GO:0042552;
GO  GO:0071901;
GO  GO:0048709;
GO  GO:1903779;
GO  GO:0014819;
GO  GO:0035725;
GO  GO:0050808;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY
SQ  FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF
SQ  IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
SQ  FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRIL
SQ  KDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFF
SQ  DPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
SQ  FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARG
SQ  TVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDR
SQ  KLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
SQ  EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTS
SQ  VPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLL
SQ  YRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
//