ID  P57760;
PN  Serine/threonine-protein kinase 16;
GN  Stk16;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.
DR  UNIPROT: P57760;
DR  Pfam: PF00069;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DE  Function: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0005798;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005524;
GO  GO:0004715;
GO  GO:0004672;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0000978;
GO  GO:0071560;
GO  GO:0045944;
GO  GO:0046777;
GO  GO:0006468;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250};
SQ  MGHALCVCSRGTVIIDNKRYLFVQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDQEEAQREADMHRLFQHPNILRL
SQ  MAYSLKERGAKHEAWLLLPFFKRGTLWNEIERLKDQGNFLTEDQILPLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEG
SQ  QPVLMDLGSMNQACIQVEGSRQALALQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQ
SQ  KGDSVALAVQNDLSIPQSPRHSSALRQLLASMMTVDPQQRPHIPVLLSQLEALQPPAPGQHTTQI
//