ID P59595; PN Nucleoprotein; GN N; OS 694009; SL Nucleus Position: SL-0382; SL Comments: Virion {ECO:0000255|HAMAP-Rule:MF_04096, ECO:0000269|PubMed:17210170, ECO:0000269|PubMed:19106108}. Host endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|HAMAP-Rule:MF_04096, ECO:0000269|PubMed:17210170}. Host Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_04096, ECO:0000269|PubMed:17210170}. Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:17210170}. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. {ECO:0000255|HAMAP-Rule:MF_04096}. DR UNIPROT: P59595; DR UNIPROT: Q7T3Z4; DR UNIPROT: Q7TA14; DR UNIPROT: Q7TF99; DR UNIPROT: Q80E50; DR PDB: 1SSK; DR PDB: 1X7Q; DR PDB: 2CJR; DR PDB: 2GIB; DR PDB: 2JW8; DR PDB: 2OFZ; DR PDB: 2OG3; DR PDB: 3I6L; DR PDB: 6IEX; DR PDB: 7LG0; DR Pfam: PF00937; DR PROSITE: PS51929; DR PROSITE: PS51928; DE Function: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455). {ECO:0000255|HAMAP- Rule:MF_04096, ECO:0000269|PubMed:17210170, ECO:0000269|PubMed:18055455}. DE Reference Proteome: Yes; DE Interaction: O43709; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O75569; IntAct: EBI-25639357; Score: 0.54 DE Interaction: P19525; IntAct: EBI-26984718; Score: 0.40 DE Interaction: P24385; IntAct: EBI-25746873; Score: 0.58 DE Interaction: P63165; IntAct: EBI-7602710; Score: 0.54 DE Interaction: P59595; IntAct: EBI-7602801; Score: 0.98 DE Interaction: P09651; IntAct: EBI-7613676; Score: 0.60 DE Interaction: P61769; IntAct: EBI-25487169; Score: 0.52 DE Interaction: P59596; IntAct: EBI-25493215; Score: 0.91 DE Interaction: P63279; IntAct: EBI-25497306; Score: 0.75 DE Interaction: Q05639; IntAct: EBI-25498109; Score: 0.69 DE Interaction: P62937; IntAct: EBI-25499625; Score: 0.68 DE Interaction: P13645; IntAct: EBI-25635560; Score: 0.35 DE Interaction: P04264; IntAct: EBI-25635560; Score: 0.35 DE Interaction: P62333; IntAct: EBI-25635560; Score: 0.56 DE Interaction: Q9HC16; IntAct: EBI-25641899; Score: 0.40 DE Interaction: P59637; IntAct: EBI-25668008; Score: 0.57 DE Interaction: P84022; IntAct: EBI-25682920; Score: 0.40 DE Interaction: P84025; IntAct: EBI-25683178; Score: 0.52 DE Interaction: P24941; IntAct: EBI-25746912; Score: 0.35 DE Interaction: P20248; IntAct: EBI-25746912; Score: 0.35 DE Interaction: P59594; IntAct: EBI-25823635; Score: 0.27 DE Interaction: Q9Y3U8; IntAct: EBI-26376911; Score: 0.35 DE Interaction: Q9HCE1; IntAct: EBI-26376911; Score: 0.35 DE Interaction: P68400; IntAct: EBI-26376911; Score: 0.35 DE Interaction: P11940; IntAct: EBI-26376911; Score: 0.53 DE Interaction: O76021; IntAct: EBI-26376911; Score: 0.35 DE Interaction: Q9UN86; IntAct: EBI-26376911; Score: 0.74 DE Interaction: Q9BQ75; IntAct: EBI-26376911; Score: 0.53 DE Interaction: Q8TAD8; IntAct: EBI-26376911; Score: 0.53 DE Interaction: Q8NCA5; IntAct: EBI-26376911; Score: 0.53 DE Interaction: Q86U42; IntAct: EBI-26376911; Score: 0.35 DE Interaction: Q6PKG0; IntAct: EBI-26376911; Score: 0.53 DE Interaction: Q13310; IntAct: EBI-26376911; Score: 0.53 DE Interaction: Q13283; IntAct: EBI-26376911; Score: 0.89 DE Interaction: P67870; IntAct: EBI-26376911; Score: 0.35 DE Interaction: P19784; IntAct: EBI-26376911; Score: 0.35 DE Interaction: P16989; IntAct: EBI-26376911; Score: 0.53 DE Interaction: O75683; IntAct: EBI-26376911; Score: 0.53 DE Interaction: O43818; IntAct: EBI-26376911; Score: 0.35 DE Interaction: Q92831; IntAct: EBI-26971417; Score: 0.44 DE Interaction: Q92830; IntAct: EBI-26971428; Score: 0.44 DE Interaction: Q14258; IntAct: EBI-27086792; Score: 0.46 DE Interaction: P23249; IntAct: EBI-27090990; Score: 0.40 DE Interaction: Q14011; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8WU68; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q13585; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8TBB5; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y388; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P20719; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NWT1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: E9PRG8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96G21; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96EU6; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96P11; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9P2D0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8WY91; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NQV6; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q32NC0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BY49; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y6Y1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q86XN8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NP64; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y3A2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q03188; IntAct: EBI-27129966; Score: 0.35 DE Interaction: A6NFI3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8WUQ7; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O15213; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q5T280; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96EZ8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O14647; IntAct: EBI-27129966; Score: 0.35 DE Interaction: A8MTY0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8IUH3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8IYN0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q86Y79; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q15397; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14191; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8TF76; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8NB50; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O95251; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BY12; IntAct: EBI-27129966; Score: 0.35 DE Interaction: A0AV96; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q6NUN9; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9P1Y6; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14119; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q6P1M3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96GY0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q13574; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8NI77; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UH17; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O75525; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P49759; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q13523; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9HAZ1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8N567; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q16698; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H7N4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q12873; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NV31; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8NEF9; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14147; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q149N8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q02880; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96BK5; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H9Y2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9P0L2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q12986; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UKM9; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8N5F7; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O95625; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96K58; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NQZ2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96MX3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96C57; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14CB8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q15776; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9GZR2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O75330; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q709F0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y3Y2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NUL7; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q5VWQ0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P49761; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H6R4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NY61; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H8H2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y2P8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q5BKZ1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P07305; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q6NZI2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H7B2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O00566; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O94761; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NUQ6; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14680; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P78332; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y4F1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8WXF0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q5VYS8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96PU8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O95453; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UL40; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q15050; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8NDT2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P49840; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9P275; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14244; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P11388; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H5H4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9HC36; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H6F5; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H7H0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9ULW3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8IYB3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q6PK04; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UGR2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q49A26; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O94813; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y5J1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BXS6; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y3C1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q6DKI1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P22492; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q12788; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NWH9; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P49841; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y4C8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P27448; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H6R0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q3KQU3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UN81; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14137; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BVJ6; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UNX4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P38935; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O43663; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q659C4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NUD5; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q01780; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P46783; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O43660; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UII4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P46779; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O60306; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q13151; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P36873; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14692; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q1KMD3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14562; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q99729; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62136; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8N9T8; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q13601; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q07666; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P07910; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P42766; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q07020; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62899; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q5SSJ5; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q96E39; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NZB2; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q13206; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P10412; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P84103; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q92522; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BVI4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P46013; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P05455; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62280; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P22087; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q52LJ0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P08708; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O00567; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P78316; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P16403; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H2U1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P40429; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q8TDD1; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BQ39; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P38159; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y224; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P26368; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62841; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P84098; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P27635; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9UNX3; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62847; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q14684; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62244; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9BZE4; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P61254; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q07955; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62277; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q6P158; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62241; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9H6S0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O43390; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P22626; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P46781; IntAct: EBI-27129966; Score: 0.35 DE Interaction: O60506; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P39023; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62750; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62753; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P18621; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9Y3I0; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P15880; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P67809; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P62701; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q9NR30; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q00839; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q08211; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q92499; IntAct: EBI-27129966; Score: 0.35 DE Interaction: P61247; IntAct: EBI-27129966; Score: 0.35 DE Interaction: Q00987; IntAct: EBI-30810851; Score: 0.40 DE Interaction: Q96CW1; IntAct: EBI-30812690; Score: 0.40 GO GO:0044172; GO GO:0044177; GO GO:0044220; GO GO:0005886; GO GO:1990904; GO GO:0019028; GO GO:0019013; GO GO:0003677; GO GO:0042802; GO GO:0060090; GO GO:0003723; GO GO:0019074; TP Membrane Topology: Unknown; Source: UniProt - Sequence Analysis; SQ MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSG SQ PDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVL SQ QLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQ SQ QQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSR SQ IGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAAD SQ MDDFSRQLQNSMSGASADSTQA //