ID  P61204;
PN  ADP-ribosylation factor 3;
GN  ARF3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus {ECO:0000269|PubMed:17555535}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17555535}.
DR  UNIPROT: P61204;
DR  UNIPROT: A8K6G8;
DR  UNIPROT: B7ZB63;
DR  UNIPROT: P16587;
DR  PDB: 6II6;
DR  Pfam: PF00025;
DR  PROSITE: PS51417;
DR  OMIM: 103190;
DR  DisGeNET: 377;
DE  Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
DE  Reference Proteome: Yes;
DE  Interaction: P54259; IntAct: EBI-951076; Score: 0.00
DE  Interaction: P53365; IntAct: EBI-640718; Score: 0.37
DE  Interaction: O15264; IntAct: EBI-2255044; Score: 0.35
DE  Interaction: O35071; IntAct: EBI-2557531; Score: 0.40
DE  Interaction: P97302; IntAct: EBI-2559511; Score: 0.40
DE  Interaction: Q8VD62; IntAct: EBI-2562857; Score: 0.40
DE  Interaction: Q5PRE5; IntAct: EBI-2563058; Score: 0.40
DE  Interaction: Q14186; IntAct: EBI-8836223; Score: 0.35
DE  Interaction: Q8TBB1; IntAct: EBI-24495699; Score: 0.56
DE  Interaction: A2A935; IntAct: EBI-21024514; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21028244; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P53367; IntAct: EBI-25568957; Score: 0.40
DE  Interaction: Q96CS3; IntAct: EBI-25770166; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-25937879; Score: 0.56
DE  Interaction: Q01995; IntAct: EBI-26878675; Score: 0.35
DE  Interaction: P34972; IntAct: EBI-26880846; Score: 0.35
DE  Interaction: Q9BXK1; IntAct: EBI-29019783; Score: 0.35
DE  Interaction: Q96ED9; IntAct: EBI-34575530; Score: 0.27
GO  GO:0070062;
GO  GO:0000139;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0006886;
GO  GO:0006890;
GO  GO:0016192;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRH
SQ  YFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
SQ  TSGDGLYEGLDWLANQLKNKK
//