ID  P62166;
PN  Neuronal calcium sensor 1;
GN  NCS1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus {ECO:0000269|PubMed:17555535}. Postsynaptic density {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11092894, ECO:0000269|PubMed:17555535}. Cytoplasm {ECO:0000250|UniProtKB:P62168}. Cell membrane {ECO:0000269|PubMed:17555535}; Peripheral membrane protein. Membrane {ECO:0000250|UniProtKB:P62168}; Lipid-anchor {ECO:0000305}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000305, ECO:0000305|PubMed:17555535}.
DR  UNIPROT: P62166;
DR  UNIPROT: E9PAY3;
DR  UNIPROT: P36610;
DR  UNIPROT: Q9UK26;
DR  PDB: 1G8I;
DR  PDB: 2LCP;
DR  PDB: 4GUK;
DR  PDB: 5O9S;
DR  PDB: 6QI4;
DR  Pfam: PF00036;
DR  Pfam: PF13499;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DR  OMIM: 603315;
DR  DisGeNET: 23413;
DE  Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: Q86UW9; IntAct: EBI-755530; Score: 0.83
DE  Interaction: P41271; IntAct: EBI-10208658; Score: 0.56
DE  Interaction: Q96ST8; IntAct: EBI-24577721; Score: 0.60
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: Q9UKN5; IntAct: EBI-24326300; Score: 0.56
DE  Interaction: P78358; IntAct: EBI-24337955; Score: 0.56
DE  Interaction: Q6FHY5; IntAct: EBI-25256722; Score: 0.56
DE  Interaction: Q9Y336; IntAct: EBI-24516320; Score: 0.56
DE  Interaction: Q7Z698; IntAct: EBI-24527170; Score: 0.56
DE  Interaction: Q96K80; IntAct: EBI-24610735; Score: 0.56
DE  Interaction: Q96C03; IntAct: EBI-24615464; Score: 0.56
DE  Interaction: O75084; IntAct: EBI-24627494; Score: 0.56
DE  Interaction: Q8IWL1; IntAct: EBI-23737805; Score: 0.56
DE  Interaction: O95868; IntAct: EBI-23779627; Score: 0.56
DE  Interaction: Q9BXJ5; IntAct: EBI-24732079; Score: 0.56
DE  Interaction: Q03060; IntAct: EBI-23799744; Score: 0.56
DE  Interaction: P10451; IntAct: EBI-24756404; Score: 0.56
DE  Interaction: O60930; IntAct: EBI-24784574; Score: 0.56
DE  Interaction: Q8TDS5; IntAct: EBI-24635892; Score: 0.56
DE  Interaction: A0A1U9X8X8; IntAct: EBI-25196535; Score: 0.56
DE  Interaction: P05362; IntAct: EBI-21568860; Score: 0.35
DE  Interaction: Q8N5S1; IntAct: EBI-21587332; Score: 0.35
DE  Interaction: Q8NFB2; IntAct: EBI-21757603; Score: 0.35
DE  Interaction: Q9UPU5; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: Q9BV23; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: Q5W0U4; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: P30419; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: P04183; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: O75175; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: O60551; IntAct: EBI-21775610; Score: 0.35
DE  Interaction: P37058; IntAct: EBI-21840509; Score: 0.35
DE  Interaction: P08637; IntAct: EBI-21864671; Score: 0.35
DE  Interaction: Q12933; IntAct: EBI-20736875; Score: 0.35
DE  Interaction: Q9BYM8; IntAct: EBI-20737060; Score: 0.35
DE  Interaction: Q9H0F6; IntAct: EBI-20737150; Score: 0.35
DE  Interaction: Q92844; IntAct: EBI-20737201; Score: 0.35
DE  Interaction: Q8NFZ5; IntAct: EBI-20738016; Score: 0.35
DE  Interaction: P21554; IntAct: EBI-21458304; Score: 0.38
DE  Interaction: Q9BXU9; IntAct: EBI-21458640; Score: 0.27
DE  Interaction: P80192; IntAct: EBI-28938802; Score: 0.35
DE  Interaction: Q5TCX8; IntAct: EBI-28941668; Score: 0.35
GO  GO:0070161;
GO  GO:0030424;
GO  GO:0005737;
GO  GO:0030425;
GO  GO:0005794;
GO  GO:0043231;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0005509;
GO  GO:0008048;
GO  GO:0005245;
GO  GO:0010975;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:25255805};
SQ  MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRI
SQ  EFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNA
SQ  DGKLTLQEFQEGSKADPSIVQALSLYDGLV
//