ID  P62168;
PN  Neuronal calcium sensor 1;
GN  Ncs1;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus {ECO:0000269|PubMed:11526106}. Postsynaptic density {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P62166}. Cytoplasm {ECO:0000269|PubMed:11526106}. Cell membrane {ECO:0000269|PubMed:11526106}. Membrane {ECO:0000250|UniProtKB:P62166, ECO:0000269|PubMed:10514519}; Lipid-anchor {ECO:0000250|UniProtKB:P62166}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000250|UniProtKB:P62166, ECO:0000269|PubMed:11526106, ECO:0000305}.
DR  UNIPROT: P62168;
DR  UNIPROT: P36610;
DR  UNIPROT: Q9UK26;
DR  PDB: 4OV2;
DR  PDB: 4YRU;
DR  PDB: 5AEQ;
DR  PDB: 5AER;
DR  PDB: 5AFP;
DR  Pfam: PF00036;
DR  Pfam: PF13499;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DE  Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. {ECO:0000269|PubMed:17502602}.
DE  Reference Proteome: Yes;
DE  Interaction: P14100; IntAct: EBI-907835; Score: 0.50
DE  Interaction: P84080; IntAct: EBI-907835; Score: 0.50
DE  Interaction: P00829; IntAct: EBI-907835; Score: 0.35
DE  Interaction: Q28115; IntAct: EBI-907835; Score: 0.35
DE  Interaction: P19120; IntAct: EBI-907835; Score: 0.35
DE  Interaction: P20004; IntAct: EBI-907835; Score: 0.35
DE  Interaction: P19483; IntAct: EBI-907835; Score: 0.35
GO  GO:0070161;
GO  GO:0030424;
GO  GO:0044305;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0098978;
GO  GO:0005794;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0098794;
GO  GO:0099524;
GO  GO:0014069;
GO  GO:0099523;
GO  GO:0005509;
GO  GO:0008048;
GO  GO:0008427;
GO  GO:0000287;
GO  GO:0019901;
GO  GO:0005245;
GO  GO:0099626;
GO  GO:0048015;
GO  GO:0045921;
GO  GO:0010975;
GO  GO:2000300;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:10514519};
SQ  MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRI
SQ  EFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNA
SQ  DGKLTLQEFQEGSKADPSIVQALSLYDGLV
//