ID  P62879;
PN  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;
GN  GNB2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16498633}. Cell membrane {ECO:0000269|PubMed:28219978}.
DR  UNIPROT: P62879;
DR  UNIPROT: B3KPU1;
DR  UNIPROT: P11016;
DR  UNIPROT: P54312;
DR  Pfam: PF00400;
DR  PROSITE: PS00678;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DR  OMIM: 139390;
DR  OMIM: 619464;
DR  OMIM: 619503;
DR  DisGeNET: 2783;
DE  Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
DE  Disease: Neurodevelopmental disorder with hypotonia and dysmorphic facies (NEDHYDF) [MIM:619503]: An autosomal dominant disorder characterized by global developmental delay, hypotonia, and variably impaired intellectual development, often with speech delay and delayed walking. Most patients have dysmorphic facial features. Clinical features are highly variable and may include congenital cardiac defects, non-specific renal anomalies, joint contractures or joint hyperextensibility, dry skin, and cryptorchidism. {ECO:0000269|PubMed:31698099, ECO:0000269|PubMed:33971351, ECO:0000269|PubMed:34183358}. Note=The disease is caused by variants affecting the gene represented in this entry. Sick sinus syndrome 4 (SSS4) [MIM:619464]: The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia- bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS4 is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Some affected individuals are asymptomatic. SSS4 inheritance is autosomal dominant. {ECO:0000269|PubMed:28219978}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: P04626; IntAct: EBI-8770853; Score: 0.35
DE  Interaction: P0C6X7; IntAct: EBI-25507431; Score: 0.37
DE  Interaction: P10909; IntAct: EBI-21693789; Score: 0.35
DE  Interaction: Q99759; IntAct: EBI-362076; Score: 0.00
DE  Interaction: Q9Y572; IntAct: EBI-363730; Score: 0.00
DE  Interaction: P04632; IntAct: EBI-732037; Score: 0.00
DE  Interaction: Q14164; IntAct: EBI-1074963; Score: 0.00
DE  Interaction: Q9Y4K3; IntAct: EBI-1079942; Score: 0.00
DE  Interaction: P49286; IntAct: EBI-1188355; Score: 0.53
DE  Interaction: Q70EL3; IntAct: EBI-2512984; Score: 0.40
DE  Interaction: P83917; IntAct: EBI-2556579; Score: 0.40
DE  Interaction: P11440; IntAct: EBI-2556914; Score: 0.40
DE  Interaction: Q8BFT2; IntAct: EBI-2558223; Score: 0.40
DE  Interaction: Q9D2X5; IntAct: EBI-2561173; Score: 0.40
DE  Interaction: Q80X56; IntAct: EBI-2561540; Score: 0.40
DE  Interaction: Q8BHX1; IntAct: EBI-2562723; Score: 0.40
DE  Interaction: Q0VEJ0; IntAct: EBI-2563897; Score: 0.40
DE  Interaction: P03372; IntAct: EBI-2878124; Score: 0.35
DE  Interaction: P48729; IntAct: EBI-3907887; Score: 0.37
DE  Interaction: P11177; IntAct: EBI-3909631; Score: 0.37
DE  Interaction: P20073; IntAct: EBI-7098405; Score: 0.37
DE  Interaction: P38936; IntAct: EBI-7123717; Score: 0.37
DE  Interaction: Q9BPY3; IntAct: EBI-7147527; Score: 0.37
DE  Interaction: P24522; IntAct: EBI-7153265; Score: 0.37
DE  Interaction: Q14451; IntAct: EBI-7160608; Score: 0.37
DE  Interaction: P49841; IntAct: EBI-7165519; Score: 0.55
DE  Interaction: P18754; IntAct: EBI-7349763; Score: 0.37
DE  Interaction: P42229; IntAct: EBI-7392908; Score: 0.37
DE  Interaction: Q15714; IntAct: EBI-7407723; Score: 0.37
DE  Interaction: P15336; IntAct: EBI-5529812; Score: 0.35
DE  Interaction: P03496; IntAct: EBI-6156949; Score: 0.35
DE  Interaction: Q9WMX2; IntAct: EBI-9079674; Score: 0.37
DE  Interaction: P42858; IntAct: EBI-9071699; Score: 0.67
DE  Interaction: P05549; IntAct: EBI-9679115; Score: 0.37
DE  Interaction: P35579; IntAct: EBI-11004631; Score: 0.35
DE  Interaction: P36895; IntAct: EBI-11008521; Score: 0.35
DE  Interaction: Q8VC57; IntAct: EBI-11009211; Score: 0.35
DE  Interaction: P80315; IntAct: EBI-11016531; Score: 0.35
DE  Interaction: P80314; IntAct: EBI-11019324; Score: 0.35
DE  Interaction: P80318; IntAct: EBI-11029579; Score: 0.35
DE  Interaction: Q96H55; IntAct: EBI-11031416; Score: 0.35
DE  Interaction: P21333; IntAct: EBI-11038784; Score: 0.35
DE  Interaction: Q61879; IntAct: EBI-11041929; Score: 0.35
DE  Interaction: P51149; IntAct: EBI-11050319; Score: 0.35
DE  Interaction: Q9JHJ0; IntAct: EBI-11063313; Score: 0.35
DE  Interaction: P58771; IntAct: EBI-11063826; Score: 0.35
DE  Interaction: Q16643; IntAct: EBI-11080402; Score: 0.35
DE  Interaction: Q8N3V7; IntAct: EBI-11086992; Score: 0.35
DE  Interaction: Q8CCJ3; IntAct: EBI-11104920; Score: 0.35
DE  Interaction: Q9Z1Z0; IntAct: EBI-11110688; Score: 0.35
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: P60033; IntAct: EBI-20568535; Score: 0.60
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q05322; IntAct: EBI-15481401; Score: 0.35
DE  Interaction: P48960; IntAct: EBI-21506471; Score: 0.35
DE  Interaction: P18075; IntAct: EBI-21530438; Score: 0.35
DE  Interaction: P28335; IntAct: EBI-21534882; Score: 0.35
DE  Interaction: Q01415; IntAct: EBI-21540352; Score: 0.35
DE  Interaction: P26842; IntAct: EBI-21555258; Score: 0.35
DE  Interaction: O14530; IntAct: EBI-21558244; Score: 0.35
DE  Interaction: Q2Y0W8; IntAct: EBI-21566582; Score: 0.35
DE  Interaction: Q9NRX5; IntAct: EBI-21567084; Score: 0.35
DE  Interaction: Q16288; IntAct: EBI-21583226; Score: 0.35
DE  Interaction: Q9H813; IntAct: EBI-21593240; Score: 0.35
DE  Interaction: Q9Y262; IntAct: EBI-21610950; Score: 0.35
DE  Interaction: Q9Y345; IntAct: EBI-21615000; Score: 0.35
DE  Interaction: Q2MV58; IntAct: EBI-21625612; Score: 0.35
DE  Interaction: Q5VTA0; IntAct: EBI-21649184; Score: 0.35
DE  Interaction: Q07954; IntAct: EBI-21684279; Score: 0.35
DE  Interaction: Q9NRE1; IntAct: EBI-21684885; Score: 0.35
DE  Interaction: Q9GZM7; IntAct: EBI-21699118; Score: 0.35
DE  Interaction: O15496; IntAct: EBI-21699277; Score: 0.35
DE  Interaction: P14091; IntAct: EBI-21699601; Score: 0.35
DE  Interaction: Q6UWB1; IntAct: EBI-21703330; Score: 0.35
DE  Interaction: Q9NVU0; IntAct: EBI-21705041; Score: 0.35
DE  Interaction: P08754; IntAct: EBI-21709056; Score: 0.35
DE  Interaction: Q9UKJ8; IntAct: EBI-21717781; Score: 0.35
DE  Interaction: Q13371; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: Q9NQP4; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: Q99471; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: Q92526; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: Q13148; IntAct: EBI-21726063; Score: 0.67
DE  Interaction: P78371; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P63218; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P63092; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P61758; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P50991; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P49368; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P40227; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P17987; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: P04083; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: O60925; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: O15212; IntAct: EBI-21726063; Score: 0.35
DE  Interaction: Q9NWX5; IntAct: EBI-21736726; Score: 0.35
DE  Interaction: P48544; IntAct: EBI-21754197; Score: 0.35
DE  Interaction: O95154; IntAct: EBI-21755189; Score: 0.35
DE  Interaction: P08833; IntAct: EBI-21768638; Score: 0.35
DE  Interaction: Q86WS5; IntAct: EBI-21771386; Score: 0.35
DE  Interaction: P30519; IntAct: EBI-21779750; Score: 0.35
DE  Interaction: Q9NTU7; IntAct: EBI-21783449; Score: 0.35
DE  Interaction: Q8WVH0; IntAct: EBI-21802744; Score: 0.35
DE  Interaction: Q6ZMY9; IntAct: EBI-21818150; Score: 0.35
DE  Interaction: Q8N1E6; IntAct: EBI-21820146; Score: 0.35
DE  Interaction: Q8WTQ1; IntAct: EBI-21825173; Score: 0.35
DE  Interaction: Q96GD3; IntAct: EBI-21834539; Score: 0.35
DE  Interaction: Q9UNU6; IntAct: EBI-21839336; Score: 0.35
DE  Interaction: Q99808; IntAct: EBI-21849345; Score: 0.35
DE  Interaction: O43827; IntAct: EBI-21853419; Score: 0.35
DE  Interaction: Q9BZP6; IntAct: EBI-21862020; Score: 0.35
DE  Interaction: P32455; IntAct: EBI-21864916; Score: 0.35
DE  Interaction: O60383; IntAct: EBI-21866276; Score: 0.35
DE  Interaction: Q8N8M0; IntAct: EBI-21867232; Score: 0.35
DE  Interaction: P28799; IntAct: EBI-21877218; Score: 0.35
DE  Interaction: P04278; IntAct: EBI-21877199; Score: 0.35
DE  Interaction: Q96CM8; IntAct: EBI-21877340; Score: 0.40
DE  Interaction: Q3SY56; IntAct: EBI-21877291; Score: 0.35
DE  Interaction: Q99518; IntAct: EBI-21877353; Score: 0.40
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: Q96I36; IntAct: EBI-16791250; Score: 0.27
DE  Interaction: P23258; IntAct: EBI-16800113; Score: 0.27
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q5T7N2; IntAct: EBI-20993270; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q9H0J9; IntAct: EBI-21263845; Score: 0.35
DE  Interaction: O43924; IntAct: EBI-21019227; Score: 0.35
DE  Interaction: Q8N6Q3; IntAct: EBI-21402192; Score: 0.35
DE  Interaction: P13569; IntAct: EBI-25416349; Score: 0.53
DE  Interaction: Q13115; IntAct: EBI-25372724; Score: 0.35
DE  Interaction: Q15139; IntAct: EBI-25395029; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: O76071; IntAct: EBI-25477658; Score: 0.35
DE  Interaction: Q9BY14; IntAct: EBI-25504841; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25637382; Score: 0.35
DE  Interaction: Q5VVX9; IntAct: EBI-25859638; Score: 0.56
DE  Interaction: Q969M7; IntAct: EBI-25859630; Score: 0.56
DE  Interaction: Q8N2K1; IntAct: EBI-25859622; Score: 0.56
DE  Interaction: Q8WVN8; IntAct: EBI-25859614; Score: 0.56
DE  Interaction: Q9H0Y0; IntAct: EBI-25859606; Score: 0.56
DE  Interaction: Q9NT62; IntAct: EBI-25859598; Score: 0.56
DE  Interaction: Q9C0C9; IntAct: EBI-25859588; Score: 0.56
DE  Interaction: Q7Z7E8; IntAct: EBI-25859570; Score: 0.56
DE  Interaction: Q9Y2X8; IntAct: EBI-25859562; Score: 0.56
DE  Interaction: Q9NPD8; IntAct: EBI-25859554; Score: 0.56
DE  Interaction: Q16763; IntAct: EBI-25859546; Score: 0.56
DE  Interaction: Q6NXQ4; IntAct: EBI-25859538; Score: 0.56
DE  Interaction: O00762; IntAct: EBI-25859524; Score: 0.56
DE  Interaction: O14933; IntAct: EBI-25859516; Score: 0.56
DE  Interaction: P61081; IntAct: EBI-25859508; Score: 0.56
DE  Interaction: P61077; IntAct: EBI-25859476; Score: 0.56
DE  Interaction: P62837; IntAct: EBI-25859468; Score: 0.56
DE  Interaction: P51668; IntAct: EBI-25859460; Score: 0.56
DE  Interaction: P61086; IntAct: EBI-25859442; Score: 0.56
DE  Interaction: Q7KZS0; IntAct: EBI-25859500; Score: 0.56
DE  Interaction: P62256; IntAct: EBI-25859492; Score: 0.56
DE  Interaction: P62253; IntAct: EBI-25859484; Score: 0.56
DE  Interaction: O60260; IntAct: EBI-25879531; Score: 0.56
DE  Interaction: P40337; IntAct: EBI-25895413; Score: 0.56
DE  Interaction: Q9Y3C5; IntAct: EBI-25918235; Score: 0.56
DE  Interaction: Q7Z699; IntAct: EBI-25930439; Score: 0.56
DE  Interaction: P00441; IntAct: EBI-25934837; Score: 0.56
DE  Interaction: P37840; IntAct: EBI-25940648; Score: 0.56
DE  Interaction: Q13363; IntAct: EBI-27047305; Score: 0.35
DE  Interaction: P35226; IntAct: EBI-27108918; Score: 0.35
DE  Interaction: Q05513; IntAct: EBI-28938998; Score: 0.35
DE  Interaction: Q12792; IntAct: EBI-28939213; Score: 0.35
DE  Interaction: Q13188; IntAct: EBI-28939324; Score: 0.35
DE  Interaction: Q86V86; IntAct: EBI-28942203; Score: 0.35
DE  Interaction: Q8IVW4; IntAct: EBI-28942376; Score: 0.35
DE  Interaction: Q8TEA7; IntAct: EBI-28943849; Score: 0.35
DE  Interaction: Q8TF76; IntAct: EBI-28943924; Score: 0.35
DE  Interaction: Q92772; IntAct: EBI-28944167; Score: 0.35
DE  Interaction: Q9HCP0; IntAct: EBI-28946348; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0005615;
GO  GO:0005925;
GO  GO:0005834;
GO  GO:0005765;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0031982;
GO  GO:0003924;
GO  GO:0051020;
GO  GO:0044877;
GO  GO:0030159;
GO  GO:0007186;
GO  GO:1901379;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI
SQ  IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS
SQ  SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA
SQ  FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGV
SQ  TDDGMAVATGSWDSFLKIWN
//