ID  P70552;
PN  GTP cyclohydrolase 1 feedback regulatory protein;
GN  Gchfr;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
DR  UNIPROT: P70552;
DR  PDB: 1IS7;
DR  PDB: 1IS8;
DR  PDB: 1JG5;
DR  PDB: 1WPL;
DR  Pfam: PF06399;
DE  Function: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
DE  Reference Proteome: Yes;
DE  Interaction: P22288; IntAct: EBI-1032731; Score: 0.62
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0042470;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0032991;
GO  GO:0016597;
GO  GO:0019899;
GO  GO:0004857;
GO  GO:0044549;
GO  GO:0030742;
GO  GO:0044877;
GO  GO:0009890;
GO  GO:0043105;
GO  GO:0065003;
GO  GO:0045428;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MPYLLISTQIRMEVGPTMVGDEHSDPELMQQLGASKRRVLGNNFYEYYVNDPPRIVLDKLECRGFRVLSMTGVGQTLVWC
SQ  LHKE
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