ID  P79135;
PN  Interferon-induced GTP-binding protein Mx1;
GN  MX1;
OS  9913;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:19951175}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20591}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20591}; Cytoplasmic side {ECO:0000250|UniProtKB:P20591}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P20591}. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region. {ECO:0000250|UniProtKB:P20591}. [Isoform 2]: Nucleus {ECO:0000269|PubMed:19951175}.
DR  UNIPROT: P79135;
DR  UNIPROT: O46623;
DR  UNIPROT: Q17QZ1;
DR  UNIPROT: Q53ZW3;
DR  UNIPROT: Q867D5;
DR  Pfam: PF01031;
DR  Pfam: PF00350;
DR  Pfam: PF02212;
DR  PROSITE: PS00410;
DR  PROSITE: PS51718;
DR  PROSITE: PS51388;
DE  Function: Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:16202617, ECO:0000269|PubMed:19951175, ECO:0000269|PubMed:22385204}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0016020;
GO  GO:0005874;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0042802;
GO  GO:0008017;
GO  GO:0140374;
GO  GO:0051607;
GO  GO:0045087;
GO  GO:0070106;
GO  GO:0045071;
GO  GO:0034340;
GO  GO:0034342;
GO  GO:0009615;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P20591};
SQ  MVHSDLGIEELDSPESSLNGSEDMESKSNLYSQYEEKVRPCIDLIDSLRSLGVEQDLALPAIAVIGDQSSGKSSVLEALS
SQ  GVALPRGSGIVTRCPLVLRLKKLGNEDEWKGKVSFLDKEIEIPDASQVEKEISEAQIAIAGEGTGISHELISLEVSSPHV
SQ  PDLTLIDLPGITRVAVGNQPPDIEYQIKSLIRKYILRQETINLVVVPANVDIATTEALRMAQEVDPQGDRTIGILTKPDL
SQ  VDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQDIKHRMSLDKALQRERIFFEDHAHFRDLLEEGKATIPCLAERLTSEL
SQ  IMHICKTLPLLENQIKETHQRITEELQKYGKDIPEEESEKMFCLIEKIDTFNKEIISTIEGEEFVEQYDSRLFTKVRAEF
SQ  SKWSAVVEKNFEKGYEAIRKEIKQFENRYRGRELPGFVNYKTFETIIKKQVRVLEEPAVDMLHTVTDIIRNTFTDVSGKH
SQ  FNEFFNLHRTAKSKIEDIRLEQENEAEKSIRLHFQMEQLVYCQDQVYRRALQQVREKEAEEEKNKKSNHYFQSQVSEPST
SQ  DEIFQHLTAYQQEVSTRISGHIPLIIQFFVLRTYGEQLKKSMLQLLQDKDQYDWLLKERTDTRDKRKFLKERLERLTRAR
SQ  QRLAKFPG
//