ID  P82471;
PN  Guanine nucleotide-binding protein G(q) subunit alpha;
GN  Gnaq;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:P50148}; Lipid-anchor {ECO:0000250|UniProtKB:P50148}. Golgi apparatus {ECO:0000250|UniProtKB:P50148}. Nucleus {ECO:0000250|UniProtKB:P21279}. Nucleus membrane {ECO:0000250|UniProtKB:P21279}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:P21279}.
DR  UNIPROT: P82471;
DR  Pfam: PF00503;
DR  PROSITE: PS51882;
DE  Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long- chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000250|UniProtKB:P50148}.
DE  Reference Proteome: Yes;
DE  Interaction: Q5XIE8; IntAct: EBI-26438079; Score: 0.35
GO  GO:0005901;
GO  GO:0044297;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0005794;
GO  GO:0005834;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0005886;
GO  GO:0045202;
GO  GO:0047391;
GO  GO:0001664;
GO  GO:0031683;
GO  GO:0005525;
GO  GO:0005096;
GO  GO:0003924;
GO  GO:0046872;
GO  GO:0044877;
GO  GO:0001508;
GO  GO:0007202;
GO  GO:0007189;
GO  GO:0007188;
GO  GO:1904888;
GO  GO:0048066;
GO  GO:0042733;
GO  GO:0086100;
GO  GO:0021884;
GO  GO:0007186;
GO  GO:0007215;
GO  GO:0007507;
GO  GO:0042711;
GO  GO:0010259;
GO  GO:0043066;
GO  GO:0043267;
GO  GO:0006469;
GO  GO:0016322;
GO  GO:0060158;
GO  GO:0007200;
GO  GO:0048661;
GO  GO:0009791;
GO  GO:0050821;
GO  GO:0008217;
GO  GO:0060828;
GO  GO:0045634;
GO  GO:0010543;
GO  GO:0001501;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P21279};
SQ  MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVY
SQ  QNIFTAMQAMVRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYY
SQ  LNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
SQ  ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDS
SQ  DKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
//