ID  P91276;
PN  Importin subunit alpha-2;
GN  ima;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:11311162, ECO:0000269|PubMed:12221121}. Nucleus {ECO:0000269|PubMed:11311162, ECO:0000269|PubMed:12221121, ECO:0000269|PubMed:30563860}. Nucleus envelope {ECO:0000269|PubMed:12221121}. Note=In interphase germ cells and embryonic cells, localizes to the cytoplasm and nuclear envelope, whereas in developing oocytes, it localizes in the cytoplasm and nucleus. {ECO:0000269|PubMed:12221121}.
DR  UNIPROT: P91276;
DR  Pfam: PF00514;
DR  Pfam: PF16186;
DR  Pfam: PF01749;
DR  PROSITE: PS50176;
DR  PROSITE: PS51214;
DE  Function: Nuclear transport receptor that mediates nuclear import of proteins, and which is involved in sister chromatid cohesion (PubMed:11311162, PubMed:12221121, PubMed:30563860). Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signals (NLS) motif (By similarity). Promotes docking of import substrates to the nuclear envelope (By similarity). Together with akir-1 adapter, required for the import and load of cohesin complex proteins in meiotic nuclei (PubMed:30563860). {ECO:0000250|UniProtKB:Q19969, ECO:0000269|PubMed:11311162, ECO:0000269|PubMed:12221121, ECO:0000269|PubMed:30563860}.
DE  Reference Proteome: Yes;
DE  Interaction: V6CLJ5; IntAct: EBI-338966; Score: 0.00
DE  Interaction: G5ECL3; IntAct: EBI-343463; Score: 0.00
DE  Interaction: Q9N2K7; IntAct: EBI-344852; Score: 0.00
DE  Interaction: O44761; IntAct: EBI-6458140; Score: 0.37
GO  GO:0005737;
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0061608;
GO  GO:0008139;
GO  GO:0009792;
GO  GO:0051177;
GO  GO:0007084;
GO  GO:0006607;
GO  GO:0006606;
GO  GO:0051983;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTLTETSLSHNAEEGKDEGGRLQQYKNLTKHEELRRRRTECSVEIRKQKGADMMMKRRNIVDVDEGGNSESELEEPEKIS
SQ  HQQSSTRLSNDEIRAILSNNPSEDDMVRCFESLRKSLSKTKNPPIDEVIHCGLLQALVQALSVENERVQYEAAWALTNIV
SQ  SGSTEQTIAAVEAGVTIPLIHLSVHQSAQISEQALWAVANIAGDSSQLRDYVIKCHGVEALMHLMEKVDQLGDSHVRTIA
SQ  WAFSNMCRHKNPHAPLEVLRVLSKGLVKLVQHTDRQVRQDACWAVSYLTDGPDEQIELARESGVLPHVVAFFKEAENLVA
SQ  PALRTLGNVATGNDSLTQAVIDLGSLDEILPLMEKTRSSSIVKECCWLVSNIIAGTQKQIQAVLDANLLPVLINVLKSGD
SQ  HKCQFEASWALSNLAQGGTNRQVVAMLEDNVVPALCQALLQTNTDMLNNTLETLYTLMLTVQNGYPHKVDILHDQVEENG
SQ  GLDSLERLQESQSEQIYTQAYRIITQFFTDDDAGEKESHENADPQDNKWSF
//