ID  P97717;
PN  Alpha-1B adrenergic receptor;
GN  Adra1b;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:22120526}; Multi-pass membrane protein {ECO:0000269|PubMed:22120526}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:P35368}. Membrane, caveola {ECO:0000250|UniProtKB:P35368}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
DR  UNIPROT: P97717;
DR  Pfam: PF00001;
DR  PROSITE: PS00237;
DR  PROSITE: PS50262;
DE  Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P70658; IntAct: EBI-21294339; Score: 0.27
GO  GO:0005901;
GO  GO:0005737;
GO  GO:0016021;
GO  GO:0005887;
GO  GO:0014704;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0030315;
GO  GO:0004937;
GO  GO:0004930;
GO  GO:0046982;
GO  GO:0071880;
GO  GO:0007512;
GO  GO:0048148;
GO  GO:0001974;
GO  GO:0061049;
GO  GO:0007267;
GO  GO:0042593;
GO  GO:0005980;
GO  GO:0007626;
GO  GO:0010259;
GO  GO:0045818;
GO  GO:0035024;
GO  GO:0150099;
GO  GO:0035265;
GO  GO:0007200;
GO  GO:0007204;
GO  GO:0045819;
GO  GO:0001996;
GO  GO:0043410;
GO  GO:0001997;
GO  GO:0045907;
GO  GO:0008217;
GO  GO:0055117;
GO  GO:0001975;
GO  GO:0009725;
GO  GO:0043278;
GO  GO:0048545;
GO  GO:0001987;
GO  GO:0008542;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250};
SQ  MNPDLDTGHNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGCLGAFILFAIVGNILVILSVACNRHLRTPTN
SQ  YFIVNLAIADLLLSFTDLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRK
SQ  AILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGV
SQ  MKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS
SQ  TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSR
SQ  KDSLDDSGSCMSGSQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPG
SQ  TEGDASNGGCDTTTDLANGQPGFKSNMPLAPGHF
//