ID  P97874;
PN  Cyclin-G-associated kinase;
GN  Gak;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions (By similarity). {ECO:0000250}.
DR  UNIPROT: P97874;
DR  Pfam: PF00226;
DR  Pfam: PF00069;
DR  Pfam: PF10409;
DR  PROSITE: PS51182;
DR  PROSITE: PS50076;
DR  PROSITE: PS51181;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DE  Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P39052; IntAct: EBI-6947872; Score: 0.38
DE  Interaction: Q5XIE8; IntAct: EBI-26440627; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005925;
GO  GO:0005794;
GO  GO:0043231;
GO  GO:0048471;
GO  GO:0031982;
GO  GO:0005524;
GO  GO:0030276;
GO  GO:0030332;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0007049;
GO  GO:0048468;
GO  GO:0072318;
GO  GO:1905224;
GO  GO:0072583;
GO  GO:0007029;
GO  GO:0009913;
GO  GO:0002064;
GO  GO:0061436;
GO  GO:0048853;
GO  GO:0007030;
GO  GO:0090160;
GO  GO:0035622;
GO  GO:0030216;
GO  GO:0010977;
GO  GO:0061351;
GO  GO:0060563;
GO  GO:2000179;
GO  GO:2000648;
GO  GO:0034067;
GO  GO:0072659;
GO  GO:0006468;
GO  GO:0006898;
GO  GO:0048863;
GO  GO:0072089;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNR
SQ  AIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLRRVECKGPLSCDSILKIFYQTCRAVQ
SQ  HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPI
SQ  GEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRGMLKVNPEERLSIAEVVRQLQEIAAAR
SQ  NVNPKAPITELLEQNGGYGNSGPSRAQPPSGGPVNSSGVLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVAN
SQ  YAKGDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNLSPRIYRASKFHNRVTECGWAVRRAPHL
SQ  HSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVCAFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYVCDM
SQ  VAEEPITPHSKPMLVKSVVMTPVPLFSKQRNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLT
SQ  IIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSRDVPPW
SQ  ENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESDSPQSSSTDTNHFLHTLDWQEEKD
SQ  PETGVDNTSPKESQSNLIADGDGSEVSDEEEASCPSEERKPGAGEDTPRLAAGTRQQDLIFDVGMLAAPQEPVQPEEGVD
SQ  LLGLHSEGDLRPAAPLQASGVQSSNTDLLSSLLEPSDASQVGPPGDLLGGETPLLLASPVSLLGVQSNLQGKVPDTVDPF
SQ  DQFLLPSSSDTQPCSKPDLFGEFLNSDSVASSTAFPSTHSAPPPSCSTAFLHLGDLPAEPNKVIASSSHPDLLGGWDTWA
SQ  ETALPGPASMPVPEGTLFSSAGHPAPPGPNPSQTKSQNPDPFADLSDLSSSLQGLPAGLPAGSFVGTSATTHKSNSSWQT
SQ  TRPTAPGTSWPPQAKPAPRASEQLRSHFSVIGAREERGVRAPSFAQKPKVSENDFEDLLPNQGFSKSDKKGPKTMAEMRK
SQ  QELARDTDPFKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMADLVTPEQVKKQYRRAVLVVHPDKATGQPYEQ
SQ  SAKMIFMELNDAWSEFENQGSRPLF
//