ID  Q00709;
PN  Apoptosis regulator Bcl-2;
GN  BCL2;
OS  9031;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P10415}; Single- pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
DR  UNIPROT: Q00709;
DR  Pfam: PF00452;
DR  Pfam: PF02180;
DR  PROSITE: PS50062;
DR  PROSITE: PS01080;
DR  PROSITE: PS01258;
DR  PROSITE: PS01259;
DR  PROSITE: PS01260;
DR  PROSITE: PS50063;
DE  Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0005741;
GO  GO:0005739;
GO  GO:0043209;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0046930;
GO  GO:0051434;
GO  GO:0015267;
GO  GO:0016248;
GO  GO:0140297;
GO  GO:0002020;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0051721;
GO  GO:0043565;
GO  GO:0031625;
GO  GO:0007015;
GO  GO:0031103;
GO  GO:0007409;
GO  GO:0001783;
GO  GO:0001782;
GO  GO:0002326;
GO  GO:0042100;
GO  GO:0050853;
GO  GO:0001662;
GO  GO:0001658;
GO  GO:0060402;
GO  GO:0043375;
GO  GO:0098609;
GO  GO:0042149;
GO  GO:0071456;
GO  GO:0071310;
GO  GO:0021747;
GO  GO:0051607;
GO  GO:0097048;
GO  GO:0048546;
GO  GO:0043583;
GO  GO:0032469;
GO  GO:1904019;
GO  GO:0097192;
GO  GO:0008625;
GO  GO:0048041;
GO  GO:0000082;
GO  GO:0022612;
GO  GO:0032835;
GO  GO:0060218;
GO  GO:0048873;
GO  GO:0008630;
GO  GO:0070059;
GO  GO:0008631;
GO  GO:0070306;
GO  GO:0002320;
GO  GO:0008584;
GO  GO:0006582;
GO  GO:0030318;
GO  GO:0014031;
GO  GO:0001656;
GO  GO:0097049;
GO  GO:0033028;
GO  GO:2000811;
GO  GO:0043066;
GO  GO:0010507;
GO  GO:0002903;
GO  GO:0010523;
GO  GO:0030308;
GO  GO:0030336;
GO  GO:0032848;
GO  GO:2000669;
GO  GO:1904036;
GO  GO:2001240;
GO  GO:2000134;
GO  GO:2001243;
GO  GO:2000672;
GO  GO:0033033;
GO  GO:0030279;
GO  GO:0033689;
GO  GO:2000378;
GO  GO:0046671;
GO  GO:0070233;
GO  GO:0042551;
GO  GO:0048599;
GO  GO:0035265;
GO  GO:0001503;
GO  GO:0033687;
GO  GO:0001541;
GO  GO:0018105;
GO  GO:0018107;
GO  GO:0048753;
GO  GO:0030890;
GO  GO:0043085;
GO  GO:0030307;
GO  GO:0045636;
GO  GO:0040018;
GO  GO:0014042;
GO  GO:0033138;
GO  GO:0048743;
GO  GO:0014911;
GO  GO:0009791;
GO  GO:0006470;
GO  GO:0000209;
GO  GO:0072593;
GO  GO:0001952;
GO  GO:0010468;
GO  GO:0010559;
GO  GO:0046902;
GO  GO:0051881;
GO  GO:0006808;
GO  GO:0032880;
GO  GO:0031647;
GO  GO:0022898;
GO  GO:0045069;
GO  GO:0001836;
GO  GO:0003014;
GO  GO:0034097;
GO  GO:0010332;
GO  GO:0051384;
GO  GO:0042542;
GO  GO:0010039;
GO  GO:0002931;
GO  GO:1904373;
GO  GO:0035094;
GO  GO:0009636;
GO  GO:0010224;
GO  GO:0009410;
GO  GO:0046666;
GO  GO:0048741;
GO  GO:0014909;
GO  GO:0048536;
GO  GO:0048864;
GO  GO:0070231;
GO  GO:0033077;
GO  GO:0043029;
GO  GO:0048538;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAHPGRRGYDNREIVLKYIHYKLSQRGYDWAAGEDRPPVPPAPAPAAAPAAVAAAGASSHHRPEPPGSAAASEVPPAEGL
SQ  RPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTPFTAHGRFVAVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREM
SQ  SPLVDNIATWMTEYLNRHLHNWIQDNGGWDAFVELYGNSMRPLFDFSWISLKTILSLVLVGACITLGAYLGHK
//