ID  Q02199;
PN  Nucleoporin NUP49/NSP49;
GN  NUP49;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: Q02199;
DR  UNIPROT: D6VTY0;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF13634;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP49 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport. {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11387327, ECO:0000269|PubMed:11689687, ECO:0000269|PubMed:12604785, ECO:0000269|PubMed:15039779, ECO:0000269|PubMed:7813444, ECO:0000269|PubMed:8524308, ECO:0000269|PubMed:9017593, ECO:0000269|PubMed:9971735}.
DE  Reference Proteome: Yes;
DE  Interaction: P14907; IntAct: EBI-801342; Score: 0.68
DE  Interaction: P32499; IntAct: EBI-6322534; Score: 0.00
DE  Interaction: P34077; IntAct: EBI-789044; Score: 0.62
DE  Interaction: P40368; IntAct: EBI-11889308; Score: 0.37
DE  Interaction: P47069; IntAct: EBI-7064868; Score: 0.27
DE  Interaction: P48837; IntAct: EBI-390870; Score: 0.90
DE  Interaction: P49686; IntAct: EBI-1269549; Score: 0.00
DE  Interaction: P49687; IntAct: EBI-11888836; Score: 0.37
DE  Interaction: P23639; IntAct: EBI-698324; Score: 0.37
DE  Interaction: P39731; IntAct: EBI-390798; Score: 0.37
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P07259; IntAct: EBI-801342; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-801342; Score: 0.35
DE  Interaction: P16861; IntAct: EBI-801342; Score: 0.35
DE  Interaction: Q06411; IntAct: EBI-857689; Score: 0.00
DE  Interaction: Q06142; IntAct: EBI-1269417; Score: 0.00
DE  Interaction: Q02630; IntAct: EBI-1269659; Score: 0.00
DE  Interaction: Q02629; IntAct: EBI-1269802; Score: 0.00
DE  Interaction: Q02199; IntAct: EBI-8276157; Score: 0.69
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: P38265; IntAct: EBI-2885494; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: Q00416; IntAct: EBI-5235312; Score: 0.37
DE  Interaction: Q05166; IntAct: EBI-11889036; Score: 0.37
DE  Interaction: Q7Z3B4; IntAct: EBI-11889006; Score: 0.37
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0042802;
GO  GO:0017056;
GO  GO:0006607;
GO  GO:0006999;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0000055;
GO  GO:0006409;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MFGLNKASSTPAGGLFGQASGASTGNANTGFSFGGTQTGQNTGPSTGGLFGAKPAGSTGGLGASFGQQQQQSQTNAFGGS
SQ  ATTGGGLFGNKPNNTANTGGGLFGANSNSNSGSLFGSNNAQTSRGLFGNNNTNNINNSSSGMNNASAGLFGSKPAGGTSL
SQ  FGNTSTSSAPAQNQGMFGAKPAGTSLFGNNAGNTTTGGGLFGSKPTGATSLFGSSNNNNNNNNSNNIMSASGGLFGNQQQ
SQ  QLQQQPQMQCALQNLSQLPITPMTRISELPPQIRQEIEQLDQYIQKQVQISHHLKADTIDHDELIDSIPRDVAYLLKSES
SQ  ATSQYLKQDLKKISSFKSLIDEDLLDTQTFSVLLQQLLTPGSKISSNDLDKFFQKKIHLYEKKLEDYCRILSDIETAVNG
SQ  IDTDLFGAPNNPNSTAITADLGSSEAENLLQLKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASLSI
//