ID  Q02410;
PN  Amyloid-beta A4 precursor protein-binding family A member 1;
GN  APBA1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:20531236}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20531236}. Nucleus {ECO:0000269|PubMed:20531236}. Note=Only about 5% of the protein is located in the nucleus. [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:23737971}.
DR  UNIPROT: Q02410;
DR  UNIPROT: O14914;
DR  UNIPROT: O60570;
DR  UNIPROT: Q5VYR8;
DR  PDB: 1AQC;
DR  PDB: 1U37;
DR  PDB: 1U38;
DR  PDB: 1U39;
DR  PDB: 1U3B;
DR  PDB: 1X11;
DR  PDB: 1X45;
DR  PDB: 1Y7N;
DR  Pfam: PF00595;
DR  Pfam: PF00640;
DR  PROSITE: PS50106;
DR  PROSITE: PS01179;
DR  OMIM: 602414;
DR  DisGeNET: 320;
DE  Function: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10- LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.
DE  Reference Proteome: Yes;
DE  Interaction: P05067; IntAct: EBI-368901; Score: 0.65
DE  Interaction: P49768; IntAct: EBI-7693425; Score: 0.70
DE  Interaction: Q00975; IntAct: EBI-7693446; Score: 0.44
DE  Interaction: Q02410; IntAct: EBI-7693492; Score: 0.37
DE  Interaction: Q5NGR3; IntAct: EBI-2808888; Score: 0.00
DE  Interaction: Q8ZD84; IntAct: EBI-2840135; Score: 0.00
DE  Interaction: A0A2S9PLH1; IntAct: EBI-2875941; Score: 0.00
DE  Interaction: P97887; IntAct: EBI-6674509; Score: 0.40
DE  Interaction: Q9NRW1; IntAct: EBI-8840227; Score: 0.62
DE  Interaction: P20340; IntAct: EBI-8840230; Score: 0.62
DE  Interaction: P35279; IntAct: EBI-8841337; Score: 0.27
DE  Interaction: O14936; IntAct: EBI-9084378; Score: 0.40
DE  Interaction: Q9NUP9; IntAct: EBI-21627409; Score: 0.35
DE  Interaction: Q99767; IntAct: EBI-21817505; Score: 0.35
DE  Interaction: K9N5R3; IntAct: EBI-26973521; Score: 0.40
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0043197;
GO  GO:0098978;
GO  GO:0005794;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0048787;
GO  GO:0098685;
GO  GO:0008021;
GO  GO:0001540;
GO  GO:0008088;
GO  GO:0007155;
GO  GO:0007268;
GO  GO:0014051;
GO  GO:0014047;
GO  GO:0001701;
GO  GO:0006886;
GO  GO:0007626;
GO  GO:0035264;
GO  GO:0007399;
GO  GO:0065003;
GO  GO:0010468;
GO  GO:2000300;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQEEEERGECLARSAS
SQ  TESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEA
SQ  MNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE
SQ  RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPA
SQ  GQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGD
SQ  SPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN
SQ  VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMAR
SQ  RRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDM
SQ  YNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS
SQ  TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATP
SQ  HEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
//