ID  Q02455;
PN  Protein MLP1;
GN  MLP1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus {ECO:0000269|PubMed:14718167, ECO:0000269|PubMed:16027220}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:24152732}. Note=Distributed fairly evenly along a C-shaped portion of the nuclear periphery, where the spindle pole body localizes in 90% of the cases. {ECO:0000269|PubMed:16027220}.
DR  UNIPROT: Q02455;
DR  UNIPROT: D6VXF5;
DR  Pfam: PF07926;
DR  PROSITE: PS51450;
DE  Function: Together with the closely related MLP2, involved in the structural and functional organization of perinuclear chromatin (PubMed:10638763). Together with MLP2, associates with the nuclear pore complex and form filamentous structures along the nuclear periphery (PubMed:10085285, PubMed:24152732). Has a role in the localization of Esc1 to nucleolar regions (PubMed:24152732). Together with MLP2, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing (PubMed:11862215). MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring (PubMed:12490156). Recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself (PubMed:12490156, PubMed:12531921, PubMed:14718167). {ECO:0000269|PubMed:10085285, ECO:0000269|PubMed:10638763, ECO:0000269|PubMed:11862215, ECO:0000269|PubMed:12490156, ECO:0000269|PubMed:12531921, ECO:0000269|PubMed:14718167, ECO:0000269|PubMed:24152732}.
DE  Reference Proteome: Yes;
DE  Interaction: P14906; IntAct: EBI-3769967; Score: 0.35
DE  Interaction: P25491; IntAct: EBI-3765167; Score: 0.35
DE  Interaction: P40457; IntAct: EBI-2212926; Score: 0.40
DE  Interaction: P32570; IntAct: EBI-806450; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-808689; Score: 0.56
DE  Interaction: P40024; IntAct: EBI-816662; Score: 0.27
DE  Interaction: Q02336; IntAct: EBI-820587; Score: 0.27
DE  Interaction: P23638; IntAct: EBI-7553011; Score: 0.40
DE  Interaction: Q07622; IntAct: EBI-8225053; Score: 0.22
DE  Interaction: P32505; IntAct: EBI-994908; Score: 0.58
DE  Interaction: Q01560; IntAct: EBI-994992; Score: 0.40
DE  Interaction: P32491; IntAct: EBI-2639782; Score: 0.40
DE  Interaction: P13186; IntAct: EBI-2640329; Score: 0.40
DE  Interaction: P32790; IntAct: EBI-7514515; Score: 0.37
DE  Interaction: Q06677; IntAct: EBI-3758621; Score: 0.35
DE  Interaction: P40564; IntAct: EBI-3760071; Score: 0.35
DE  Interaction: P39102; IntAct: EBI-3761494; Score: 0.35
DE  Interaction: P53863; IntAct: EBI-3769389; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3772409; Score: 0.35
DE  Interaction: P09435; IntAct: EBI-3775414; Score: 0.35
DE  Interaction: P32590; IntAct: EBI-3776763; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3781040; Score: 0.35
DE  Interaction: P39987; IntAct: EBI-3787826; Score: 0.35
DE  Interaction: P38788; IntAct: EBI-3790511; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3799302; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3806004; Score: 0.35
DE  Interaction: P02829; IntAct: EBI-3812463; Score: 0.35
DE  Interaction: P39078; IntAct: EBI-3822418; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3825702; Score: 0.35
DE  Interaction: Q12329; IntAct: EBI-3829128; Score: 0.35
DE  Interaction: Q04432; IntAct: EBI-3830630; Score: 0.35
DE  Interaction: P22943; IntAct: EBI-3831347; Score: 0.35
DE  Interaction: YGR032W; IntAct: EBI-3952595; Score: 0.35
DE  Interaction: P39523; IntAct: EBI-9976090; Score: 0.35
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0044615;
GO  GO:0005654;
GO  GO:0003729;
GO  GO:0140586;
GO  GO:0043021;
GO  GO:0017056;
GO  GO:0006281;
GO  GO:0006406;
GO  GO:1901925;
GO  GO:0071028;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0006606;
GO  GO:0090204;
GO  GO:0034398;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSENLKVTVSFDELKASSLKKIDG
SQ  LKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRV
SQ  ENNRSNSECKKLRSTIMDLETKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIR
SQ  NELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLESQLNAVKEELNSI
SQ  RELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKECLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTK
SQ  EHLQNQIETFIVELEHKVPIINSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDL
SQ  CRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNIIQLQEKNAELLKVVRNLADKL
SQ  ESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQV
SQ  QDLQTRISQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNT
SQ  ILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSLRIMVTQLQTLQKEREDLLEE
SQ  TRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLE
SQ  KEIEEDKIRLHTYNVMDETINDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTD
SQ  EKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYESKLSKIQNDLDQQTIYANTAQ
SQ  NNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQLENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLL
SQ  YDQIQIYTAADKEVNNSTNGPGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHS
SQ  SIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTALKYSMQEKEQELKLAKEEVH
SQ  RWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKERQGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDA
SQ  KNVLENSLSEANARIEELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQR
SQ  QIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQK
SQ  IREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQ
SQ  EELKDVPHSSHISDDERDKLRAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPP
SQ  KSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQNDNDKRESLANKTDPPTHLEP
SQ  SFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRNVQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELK
SQ  NDEDDTTENINESKKIKTEDEEEKETDKVNDENSI
//