ID  Q02629;
PN  Nucleoporin NUP100/NSP100;
GN  NUP100;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side.
DR  UNIPROT: Q02629;
DR  UNIPROT: D6VXL9;
DR  Pfam: PF04096;
DR  Pfam: PF13634;
DR  PROSITE: PS51434;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP100 plays an important role in several nuclear export and import pathways including poly(A)+ RNA and protein transport. {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11104765, ECO:0000269|PubMed:11387327, ECO:0000269|PubMed:12372823, ECO:0000269|PubMed:12543930, ECO:0000269|PubMed:12604785, ECO:0000269|PubMed:12917401, ECO:0000269|PubMed:15039779, ECO:0000269|PubMed:8044840, ECO:0000269|PubMed:8557738}.
DE  Reference Proteome: Yes;
DE  Interaction: P34077; IntAct: EBI-1269879; Score: 0.00
DE  Interaction: P35729; IntAct: EBI-1269846; Score: 0.00
DE  Interaction: P38181; IntAct: EBI-1269835; Score: 0.00
DE  Interaction: P40064; IntAct: EBI-6340320; Score: 0.00
DE  Interaction: P40368; IntAct: EBI-11889216; Score: 0.55
DE  Interaction: P46673; IntAct: EBI-11889530; Score: 0.59
DE  Interaction: P48837; IntAct: EBI-1266728; Score: 0.53
DE  Interaction: P49686; IntAct: EBI-1269516; Score: 0.00
DE  Interaction: P49687; IntAct: EBI-1269780; Score: 0.00
DE  Interaction: P52593; IntAct: EBI-11888868; Score: 0.37
DE  Interaction: P52891; IntAct: EBI-11889422; Score: 0.59
DE  Interaction: P61970; IntAct: EBI-15747947; Score: 0.44
DE  Interaction: Q02199; IntAct: EBI-1269802; Score: 0.00
DE  Interaction: P48562; IntAct: EBI-393057; Score: 0.37
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.53
DE  Interaction: P53035; IntAct: EBI-854602; Score: 0.00
DE  Interaction: Q02159; IntAct: EBI-859483; Score: 0.00
DE  Interaction: Q02630; IntAct: EBI-1266671; Score: 0.65
DE  Interaction: Q06142; IntAct: EBI-1566666; Score: 0.82
DE  Interaction: Q02629; IntAct: EBI-1269769; Score: 0.00
DE  Interaction: Q05166; IntAct: EBI-1269813; Score: 0.00
DE  Interaction: Q99257; IntAct: EBI-1566656; Score: 0.44
DE  Interaction: P43603; IntAct: EBI-2344068; Score: 0.37
DE  Interaction: P40482; IntAct: EBI-2344542; Score: 0.37
DE  Interaction: P53038; IntAct: EBI-2345945; Score: 0.37
DE  Interaction: P24870; IntAct: EBI-2611503; Score: 0.35
DE  Interaction: P24869; IntAct: EBI-2617071; Score: 0.35
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: P11484; IntAct: EBI-3781717; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3799829; Score: 0.35
DE  Interaction: P38315; IntAct: EBI-16251716; Score: 0.00
DE  Interaction: P40971; IntAct: EBI-16294029; Score: 0.00
DE  Interaction: P52918; IntAct: EBI-16297131; Score: 0.00
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0044614;
GO  GO:0060090;
GO  GO:0017056;
GO  GO:0006406;
GO  GO:0031990;
GO  GO:0006607;
GO  GO:0006913;
GO  GO:0045893;
GO  GO:0000973;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0006405;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MFGNNRPMFGGSNLSFGSNTSSFGGQQSQQPNSLFGNSNNNNNSTSNNAQSGFGGFTSAAGSNSNSLFGNNNTQNNGAFG
SQ  QSMGATQNSPFGSLNSSNASNGNTFGGSSSMGSFGGNTNNAFNNNSNSTNSPFGFNKPNTGGTLFGSQNNNSAGTSSLFG
SQ  GQSTSTTGTFGNTGSSFGTGLNGNGSNIFGAGNNSQSNTTGSLFGNQQSSAFGTNNQQGSLFGQQSQNTNNAFGNQNQLG
SQ  GSSFGSKPVGSGSLFGQSNNTLGNTTNNRNGLFGQMNSSNQGSSNSGLFGQNSMNSSTQGVFGQNNNQMQINGNNNNSLF
SQ  GKANTFSNSASGGLFGQNNQQQGSGLFGQNSQTSGSSGLFGQNNQKQPNTFTQSNTGIGLFGQNNNQQQQSTGLFGAKPA
SQ  GTTGSLFGGNSSTQPNSLFGTTNVPTSNTQSQQGNSLFGATKLTNMPFGGNPTANQSGSGNSLFGTKPASTTGSLFGNNT
SQ  ASTTVPSTNGLFGNNANNSTSTTNTGLFGAKPDSQSKPALGGGLFGNSNSNSSTIGQNKPVFGGTTQNTGLFGATGTNSS
SQ  AVGSTGKLFGQNNNTLNVGTQNVPPVNNTTQNALLGTTAVPSLQQAPVTNEQLFSKISIPNSITNPVKATTSKVNADMKR
SQ  NSSLTSAYRLAPKPLFAPSSNGDAKFQKWGKTLERSDRGSSTSNSITDPESSYLNSNDLLFDPDRRYLKHLVIKNNKNLN
SQ  VINHNDDEASKVKLVTFTTESASKDDQASSSIAASKLTEKAHSPQTDLKDDHDESTPDPQSKSPNGSTSIPMIENEKISS
SQ  KVPGLLSNDVTFFKNNYYISPSIETLGNKSLIELRKINNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDLVTFGPKSCSI
SQ  YENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNITHPLLKRSIAKLKENPVYKFESYDPVTGTYSYTIDHPVLT
//