ID  Q02821;
PN  Importin subunit alpha;
GN  SRP1;
OS  559292;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Note=Mainly localized at the periphery of the nucleus.
DR  UNIPROT: Q02821;
DR  UNIPROT: D6W0Z8;
DR  PDB: 1BK5;
DR  PDB: 1BK6;
DR  PDB: 1EE4;
DR  PDB: 1EE5;
DR  PDB: 1UN0;
DR  PDB: 1WA5;
DR  PDB: 2C1T;
DR  PDB: 4PVZ;
DR  PDB: 4XZR;
DR  PDB: 5H2W;
DR  PDB: 5H2X;
DR  PDB: 5T94;
DR  Pfam: PF00514;
DR  Pfam: PF16186;
DR  Pfam: PF01749;
DR  PROSITE: PS50176;
DR  PROSITE: PS51214;
DE  Function: Functions in nuclear protein import as an adapter protein for importin beta nuclear receptors (PubMed:10913188). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:10745017). Promotes docking of import substrates to the nuclear envelope (PubMed:8521485). Together with importin beta KAP95, mediates nuclear import of transcription factor GCN4 (PubMed:14648200). Together with tethering factor STS1, targets the proteasome to the nucleus (PubMed:10913188, PubMed:21075847). {ECO:0000269|PubMed:10745017, ECO:0000269|PubMed:10913188, ECO:0000269|PubMed:14648200, ECO:0000269|PubMed:21075847, ECO:0000269|PubMed:8521485}.
DE  Reference Proteome: Yes;
DE  Interaction: P20591; IntAct: EBI-11534426; Score: 0.56
DE  Interaction: P20676; IntAct: EBI-789997; Score: 0.69
DE  Interaction: P32499; IntAct: EBI-801825; Score: 0.78
DE  Interaction: P34160; IntAct: EBI-806268; Score: 0.69
DE  Interaction: P39705; IntAct: EBI-802293; Score: 0.69
DE  Interaction: P40069; IntAct: EBI-804491; Score: 0.53
DE  Interaction: P22768; IntAct: EBI-391461; Score: 0.37
DE  Interaction: P00812; IntAct: EBI-391464; Score: 0.37
DE  Interaction: P33317; IntAct: EBI-391467; Score: 0.37
DE  Interaction: Q12178; IntAct: EBI-391470; Score: 0.37
DE  Interaction: P28240; IntAct: EBI-391473; Score: 0.37
DE  Interaction: P06106; IntAct: EBI-391476; Score: 0.37
DE  Interaction: P53081; IntAct: EBI-391479; Score: 0.37
DE  Interaction: P19881; IntAct: EBI-391482; Score: 0.37
DE  Interaction: P36068; IntAct: EBI-391485; Score: 0.37
DE  Interaction: P35497; IntAct: EBI-391488; Score: 0.37
DE  Interaction: P41835; IntAct: EBI-391491; Score: 0.37
DE  Interaction: P34760; IntAct: EBI-391494; Score: 0.37
DE  Interaction: P47165; IntAct: EBI-391497; Score: 0.37
DE  Interaction: P38749; IntAct: EBI-391500; Score: 0.37
DE  Interaction: P43543; IntAct: EBI-391503; Score: 0.37
DE  Interaction: P53215; IntAct: EBI-391506; Score: 0.37
DE  Interaction: Q05016; IntAct: EBI-391509; Score: 0.37
DE  Interaction: P15108; IntAct: EBI-708957; Score: 0.56
DE  Interaction: Q06142; IntAct: EBI-784458; Score: 0.94
DE  Interaction: P46948; IntAct: EBI-789541; Score: 0.35
DE  Interaction: P38792; IntAct: EBI-791854; Score: 0.53
DE  Interaction: P32799; IntAct: EBI-792386; Score: 0.35
DE  Interaction: P53859; IntAct: EBI-792516; Score: 0.35
DE  Interaction: P27466; IntAct: EBI-793512; Score: 0.35
DE  Interaction: P36124; IntAct: EBI-794754; Score: 0.53
DE  Interaction: Q12149; IntAct: EBI-796196; Score: 0.67
DE  Interaction: Q02724; IntAct: EBI-797293; Score: 0.59
DE  Interaction: Q12124; IntAct: EBI-797390; Score: 0.35
DE  Interaction: Q08278; IntAct: EBI-799246; Score: 0.35
DE  Interaction: P53833; IntAct: EBI-799459; Score: 0.35
DE  Interaction: P13259; IntAct: EBI-799593; Score: 0.69
DE  Interaction: P53256; IntAct: EBI-800712; Score: 0.35
DE  Interaction: P53881; IntAct: EBI-800899; Score: 0.35
DE  Interaction: P50111; IntAct: EBI-803477; Score: 0.35
DE  Interaction: P22215; IntAct: EBI-804242; Score: 0.35
DE  Interaction: P53866; IntAct: EBI-804491; Score: 0.35
DE  Interaction: P32337; IntAct: EBI-804491; Score: 0.35
DE  Interaction: P41940; IntAct: EBI-804491; Score: 0.35
DE  Interaction: P00330; IntAct: EBI-804491; Score: 0.35
DE  Interaction: Q12449; IntAct: EBI-807743; Score: 0.35
DE  Interaction: Q08285; IntAct: EBI-808713; Score: 0.35
DE  Interaction: Q05636; IntAct: EBI-809094; Score: 0.35
DE  Interaction: Q08920; IntAct: EBI-810994; Score: 0.77
DE  Interaction: Q12464; IntAct: EBI-811656; Score: 0.53
DE  Interaction: P28003; IntAct: EBI-815383; Score: 0.27
DE  Interaction: Q06218; IntAct: EBI-817288; Score: 0.27
DE  Interaction: Q12277; IntAct: EBI-6963562; Score: 0.40
DE  Interaction: P25359; IntAct: EBI-6964469; Score: 0.56
DE  Interaction: Q05543; IntAct: EBI-6995482; Score: 0.56
DE  Interaction: Q12460; IntAct: EBI-7021190; Score: 0.40
DE  Interaction: P22579; IntAct: EBI-7021237; Score: 0.67
DE  Interaction: Q06697; IntAct: EBI-7044996; Score: 0.40
DE  Interaction: P53072; IntAct: EBI-7153795; Score: 0.40
DE  Interaction: Q05900; IntAct: EBI-7156793; Score: 0.40
DE  Interaction: P47108; IntAct: EBI-7162569; Score: 0.44
DE  Interaction: P38806; IntAct: EBI-7181311; Score: 0.40
DE  Interaction: P53911; IntAct: EBI-7184902; Score: 0.40
DE  Interaction: Q08162; IntAct: EBI-7271310; Score: 0.56
DE  Interaction: P32324; IntAct: EBI-7286906; Score: 0.56
DE  Interaction: P19659; IntAct: EBI-7307988; Score: 0.40
DE  Interaction: Q12499; IntAct: EBI-7435045; Score: 0.40
DE  Interaction: P53261; IntAct: EBI-7436958; Score: 0.56
DE  Interaction: P53397; IntAct: EBI-7440707; Score: 0.44
DE  Interaction: P22216; IntAct: EBI-7509953; Score: 0.69
DE  Interaction: Q04779; IntAct: EBI-7512888; Score: 0.40
DE  Interaction: P53552; IntAct: EBI-7519241; Score: 0.56
DE  Interaction: P49723; IntAct: EBI-7582150; Score: 0.40
DE  Interaction: P06843; IntAct: EBI-7751879; Score: 0.56
DE  Interaction: Q01476; IntAct: EBI-7792448; Score: 0.40
DE  Interaction: Q04500; IntAct: EBI-7810284; Score: 0.40
DE  Interaction: P22936; IntAct: EBI-7900920; Score: 0.40
DE  Interaction: P36036; IntAct: EBI-8226241; Score: 0.22
DE  Interaction: P33307; IntAct: EBI-1041382; Score: 0.57
DE  Interaction: P32562; IntAct: EBI-2112894; Score: 0.53
DE  Interaction: P06700; IntAct: EBI-2212712; Score: 0.40
DE  Interaction: Q04087; IntAct: EBI-2212766; Score: 0.40
DE  Interaction: Q08904; IntAct: EBI-2344792; Score: 0.37
DE  Interaction: P53184; IntAct: EBI-2345292; Score: 0.37
DE  Interaction: P51601; IntAct: EBI-2345314; Score: 0.37
DE  Interaction: P25367; IntAct: EBI-2345326; Score: 0.37
DE  Interaction: P08536; IntAct: EBI-2345887; Score: 0.37
DE  Interaction: Q03063; IntAct: EBI-2345890; Score: 0.37
DE  Interaction: P17423; IntAct: EBI-2345893; Score: 0.37
DE  Interaction: P60010; IntAct: EBI-2346004; Score: 0.37
DE  Interaction: P38821; IntAct: EBI-2346115; Score: 0.37
DE  Interaction: Q02895; IntAct: EBI-2346118; Score: 0.37
DE  Interaction: Q12306; IntAct: EBI-2346577; Score: 0.37
DE  Interaction: Q06549; IntAct: EBI-2346610; Score: 0.37
DE  Interaction: P32318; IntAct: EBI-2346619; Score: 0.37
DE  Interaction: P43619; IntAct: EBI-2346747; Score: 0.37
DE  Interaction: Q03373; IntAct: EBI-2346812; Score: 0.55
DE  Interaction: P09201; IntAct: EBI-2346852; Score: 0.37
DE  Interaction: Q12189; IntAct: EBI-2347997; Score: 0.37
DE  Interaction: P15202; IntAct: EBI-2348000; Score: 0.37
DE  Interaction: P18759; IntAct: EBI-2348009; Score: 0.37
DE  Interaction: P38716; IntAct: EBI-2348021; Score: 0.37
DE  Interaction: Q12206; IntAct: EBI-2348042; Score: 0.37
DE  Interaction: P37366; IntAct: EBI-2611238; Score: 0.35
DE  Interaction: P13365; IntAct: EBI-2611665; Score: 0.35
DE  Interaction: P32350; IntAct: EBI-2612391; Score: 0.35
DE  Interaction: P40187; IntAct: EBI-2612903; Score: 0.35
DE  Interaction: P38089; IntAct: EBI-2613131; Score: 0.35
DE  Interaction: Q12224; IntAct: EBI-2613375; Score: 0.35
DE  Interaction: P38255; IntAct: EBI-2613514; Score: 0.35
DE  Interaction: P32447; IntAct: EBI-2881693; Score: 0.00
DE  Interaction: Q12495; IntAct: EBI-16280136; Score: 0.53
DE  Interaction: Q02796; IntAct: EBI-2885546; Score: 0.00
DE  Interaction: Q04116; IntAct: EBI-2889029; Score: 0.00
DE  Interaction: P25303; IntAct: EBI-3659819; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3677844; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3784104; Score: 0.35
DE  Interaction: P50875; IntAct: EBI-4376349; Score: 0.35
DE  Interaction: P50102; IntAct: EBI-4380099; Score: 0.35
DE  Interaction: P38129; IntAct: EBI-4380674; Score: 0.35
DE  Interaction: Q05027; IntAct: EBI-4382094; Score: 0.35
DE  Interaction: P35177; IntAct: EBI-4383599; Score: 0.35
DE  Interaction: Q03330; IntAct: EBI-4385804; Score: 0.35
DE  Interaction: P53131; IntAct: EBI-10903607; Score: 0.35
DE  Interaction: O00635; IntAct: EBI-11534408; Score: 0.56
DE  Interaction: Q7Z6G3; IntAct: EBI-11534397; Score: 0.56
DE  Interaction: A0A0C4DGF1; IntAct: EBI-11534388; Score: 0.56
DE  Interaction: Q96A10; IntAct: EBI-11534379; Score: 0.56
DE  Interaction: P60709; IntAct: EBI-11534454; Score: 0.56
DE  Interaction: P35520; IntAct: EBI-11534444; Score: 0.56
DE  Interaction: P22234; IntAct: EBI-11534435; Score: 0.56
DE  Interaction: P13196; IntAct: EBI-11534417; Score: 0.56
DE  Interaction: Q13557; IntAct: EBI-11534487; Score: 0.56
DE  Interaction: Q13137; IntAct: EBI-11534474; Score: 0.56
DE  Interaction: P63261; IntAct: EBI-11534464; Score: 0.56
DE  Interaction: Q9NS73; IntAct: EBI-11534541; Score: 0.56
DE  Interaction: Q9HAN9; IntAct: EBI-11534532; Score: 0.56
DE  Interaction: Q8WVF5; IntAct: EBI-11534523; Score: 0.56
DE  Interaction: Q15041; IntAct: EBI-11534514; Score: 0.56
DE  Interaction: Q15038; IntAct: EBI-11534505; Score: 0.56
DE  Interaction: Q13867; IntAct: EBI-11534496; Score: 0.56
DE  Interaction: Q9NVV9; IntAct: EBI-11534559; Score: 0.56
DE  Interaction: Q14974; IntAct: EBI-13942487; Score: 0.44
DE  Interaction: Q03281; IntAct: EBI-15598611; Score: 0.76
DE  Interaction: Q03707; IntAct: EBI-16159762; Score: 0.68
DE  Interaction: P05221; IntAct: EBI-16159838; Score: 0.56
DE  Interaction: P33322; IntAct: EBI-16265066; Score: 0.35
DE  Interaction: P47027; IntAct: EBI-16268315; Score: 0.35
DE  Interaction: P34252; IntAct: EBI-16268369; Score: 0.35
DE  Interaction: P21268; IntAct: EBI-16269078; Score: 0.35
DE  Interaction: P40316; IntAct: EBI-16275395; Score: 0.35
DE  Interaction: P40348; IntAct: EBI-16279429; Score: 0.35
DE  Interaction: Q12749; IntAct: EBI-16279839; Score: 0.35
DE  Interaction: P22470; IntAct: EBI-16281382; Score: 0.35
DE  Interaction: P11978; IntAct: EBI-16282672; Score: 0.35
DE  Interaction: Q00916; IntAct: EBI-16283579; Score: 0.35
DE  Interaction: Q03010; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P38811; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P15019; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P0CS90; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q03782; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P38262; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P39954; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q02555; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P21538; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P12709; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P06169; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P29468; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q00539; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P33441; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P05694; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P00958; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P17629; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q03532; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q07623; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P45976; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P14540; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q12432; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P54115; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: P19414; IntAct: EBI-16284085; Score: 0.35
DE  Interaction: Q12476; IntAct: EBI-16287516; Score: 0.35
DE  Interaction: Q07930; IntAct: EBI-16290646; Score: 0.35
DE  Interaction: Q00416; IntAct: EBI-16421063; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0042564;
GO  GO:0005635;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0097718;
GO  GO:0061608;
GO  GO:0008139;
GO  GO:0044877;
GO  GO:0051170;
GO  GO:0006607;
GO  GO:0031144;
GO  GO:0006606;
GO  GO:0006612;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDNGTDSSTSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIPPTDGADSDEEDESSVSADQQ
SQ  FYSQLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIAS
SQ  GTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLS
SQ  NLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPAL
SQ  RAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTK
SQ  KEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKA
SQ  GGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQNAGNTFGFGSNVNQQFNFN
//