ID  Q03001;
PN  Dystonin;
GN  DST;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11751855, ECO:0000269|PubMed:19932097}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q91ZU6}. Cell projection, axon {ECO:0000250|UniProtKB:Q91ZU6}. Note=Associates with intermediate filaments, actin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells (By similarity). Associated at the growing distal tip of microtubules. {ECO:0000250|UniProtKB:Q91ZU6}. [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, H zone {ECO:0000250}. Note=Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane. {ECO:0000250}. [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes both cortical and cytoplasmic actin filaments. {ECO:0000250}. [Isoform 3]: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Note=Localizes to actin and intermediate filaments cytoskeletons (By similarity). Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes. {ECO:0000250}. [Isoform 6]: Nucleus {ECO:0000250|UniProtKB:Q91ZU6}. Nucleus envelope {ECO:0000269|PubMed:10428034}. Membrane {ECO:0000269|PubMed:10428034}; Single-pass membrane protein {ECO:0000269|PubMed:10428034}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91ZU6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q91ZU6}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10428034}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q91ZU6}. Note=Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus (By similarity). Associates with actin cytoskeleton in sensory neurons. {ECO:0000250|UniProtKB:Q91ZU6}. [Isoform 7]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10428034}. Cell projection, axon {ECO:0000269|PubMed:10428034}. Membrane {ECO:0000269|PubMed:10428034}. Note=Associates with axonal microtubules and intermediate filaments, but not with actin cytoskeleton, in sensory neurons. [Isoform 8]: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
DR  UNIPROT: Q03001;
DR  UNIPROT: B7Z3H1;
DR  UNIPROT: E7ERU0;
DR  UNIPROT: O94833;
DR  UNIPROT: Q12825;
DR  UNIPROT: Q13266;
DR  UNIPROT: Q13267;
DR  UNIPROT: Q13775;
DR  UNIPROT: Q5TBT0;
DR  UNIPROT: Q5TBT2;
DR  UNIPROT: Q5TF23;
DR  UNIPROT: Q5TF24;
DR  UNIPROT: Q8N1T8;
DR  UNIPROT: Q8N8J3;
DR  UNIPROT: Q8WXK8;
DR  UNIPROT: Q8WXK9;
DR  UNIPROT: Q96AK9;
DR  UNIPROT: Q96DQ5;
DR  UNIPROT: Q96J76;
DR  UNIPROT: Q96QT5;
DR  UNIPROT: Q9H555;
DR  UNIPROT: Q9UGD7;
DR  UNIPROT: Q9UGD8;
DR  UNIPROT: Q9UN10;
DR  PDB: 3GJO;
DR  Pfam: PF00307;
DR  Pfam: PF13499;
DR  Pfam: PF02187;
DR  Pfam: PF00681;
DR  Pfam: PF17902;
DR  Pfam: PF00435;
DR  Pfam: PF18373;
DR  PROSITE: PS00019;
DR  PROSITE: PS00020;
DR  PROSITE: PS50021;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DR  PROSITE: PS51460;
DR  PROSITE: PS50002;
DR  OMIM: 113810;
DR  OMIM: 614653;
DR  OMIM: 615425;
DR  DisGeNET: 667;
DE  Function: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}. [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}. [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
DE  Disease: Neuropathy, hereditary sensory and autonomic, 6 (HSAN6) [MIM:614653]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN6 is a severe autosomal recessive disorder characterized by neonatal hypotonia, respiratory and feeding difficulties, lack of psychomotor development, and autonomic abnormalities including labile cardiovascular function, lack of corneal reflexes leading to corneal scarring, areflexia, and absent axonal flare response after intradermal histamine injection. {ECO:0000269|PubMed:22522446}. Note=The disease is caused by variants affecting the gene represented in this entry. Epidermolysis bullosa simplex 3, localized or generalized intermediate, with BP230 deficiency (EBS3) [MIM:615425]: A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. EBS3 is an autosomal recessive disorder characterized by skin blistering mainly occurring on the feet and ankles. Ultrastructural analysis of skin biopsy shows abnormal hemidesmosomes with poorly formed inner plaques. {ECO:0000269|PubMed:20164846, ECO:0000269|PubMed:22113475}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: O95295; IntAct: EBI-5664296; Score: 0.00
DE  Interaction: P04626; IntAct: EBI-25367963; Score: 0.37
DE  Interaction: P29991; IntAct: EBI-8828450; Score: 0.37
DE  Interaction: Q9NYQ7; IntAct: EBI-311579; Score: 0.37
DE  Interaction: Q9HCM3; IntAct: EBI-311727; Score: 0.37
DE  Interaction: P62993; IntAct: EBI-350217; Score: 0.35
DE  Interaction: Q9BZL6; IntAct: EBI-7235479; Score: 0.37
DE  Interaction: O15198; IntAct: EBI-7263646; Score: 0.37
DE  Interaction: Q15287; IntAct: EBI-1065372; Score: 0.00
DE  Interaction: P15121; IntAct: EBI-1067054; Score: 0.00
DE  Interaction: Q9UHX1; IntAct: EBI-1077592; Score: 0.00
DE  Interaction: Q9NRI5; IntAct: EBI-1105693; Score: 0.00
DE  Interaction: Q9NV70; IntAct: EBI-1105725; Score: 0.00
DE  Interaction: Q9UKE5; IntAct: EBI-1105730; Score: 0.00
DE  Interaction: Q8TDR0; IntAct: EBI-1105735; Score: 0.00
DE  Interaction: Q15691; IntAct: EBI-2409886; Score: 0.73
DE  Interaction: P19838; IntAct: EBI-2680933; Score: 0.00
DE  Interaction: Q13951; IntAct: EBI-2691963; Score: 0.00
DE  Interaction: P25054; IntAct: EBI-3436852; Score: 0.00
DE  Interaction: Q16659; IntAct: EBI-3444390; Score: 0.00
DE  Interaction: Q13952; IntAct: EBI-3446173; Score: 0.00
DE  Interaction: Q13177; IntAct: EBI-3446930; Score: 0.00
DE  Interaction: Q96CV9; IntAct: EBI-5357450; Score: 0.45
DE  Interaction: Q9UKG1; IntAct: EBI-5357625; Score: 0.45
DE  Interaction: Q8IZP0; IntAct: EBI-5652673; Score: 0.00
DE  Interaction: Q15327; IntAct: EBI-5653401; Score: 0.00
DE  Interaction: P0C862; IntAct: EBI-5654717; Score: 0.00
DE  Interaction: Q8N3C7; IntAct: EBI-5655638; Score: 0.00
DE  Interaction: Q14324; IntAct: EBI-5660966; Score: 0.00
DE  Interaction: O75386; IntAct: EBI-5666780; Score: 0.00
DE  Interaction: Q13188; IntAct: EBI-6256382; Score: 0.35
DE  Interaction: Q61166; IntAct: EBI-8062428; Score: 0.70
DE  Interaction: Q99IB8; IntAct: EBI-6928217; Score: 0.37
DE  Interaction: Q9H8S9; IntAct: EBI-8798967; Score: 0.27
DE  Interaction: Q7L9L4; IntAct: EBI-8799069; Score: 0.27
DE  Interaction: O00161; IntAct: EBI-11294079; Score: 0.37
DE  Interaction: O41952; IntAct: EBI-9640619; Score: 0.37
DE  Interaction: P88986; IntAct: EBI-9640971; Score: 0.37
DE  Interaction: O41970; IntAct: EBI-9641577; Score: 0.37
DE  Interaction: Q9NQW6; IntAct: EBI-11009421; Score: 0.35
DE  Interaction: Q9D6P8; IntAct: EBI-11062262; Score: 0.35
DE  Interaction: Q3UH45; IntAct: EBI-11090763; Score: 0.35
DE  Interaction: P35579; IntAct: EBI-11144042; Score: 0.35
DE  Interaction: Q5JU00; IntAct: EBI-11367780; Score: 0.27
DE  Interaction: Q86X19; IntAct: EBI-11390509; Score: 0.27
DE  Interaction: P49286; IntAct: EBI-11577533; Score: 0.00
DE  Interaction: Q67020; IntAct: EBI-11514491; Score: 0.37
DE  Interaction: P43355; IntAct: EBI-21634905; Score: 0.35
DE  Interaction: Q9H9Q2; IntAct: EBI-21739689; Score: 0.35
DE  Interaction: Q5SQX6; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: O15155; IntAct: EBI-16788067; Score: 0.27
DE  Interaction: P15311; IntAct: EBI-16791848; Score: 0.27
DE  Interaction: P49841; IntAct: EBI-16793176; Score: 0.27
DE  Interaction: P11279; IntAct: EBI-16794808; Score: 0.27
DE  Interaction: P51151; IntAct: EBI-16798325; Score: 0.27
DE  Interaction: O43493; IntAct: EBI-16800265; Score: 0.27
DE  Interaction: Q15388; IntAct: EBI-16801791; Score: 0.27
DE  Interaction: Q9NS69; IntAct: EBI-16802054; Score: 0.27
DE  Interaction: P46013; IntAct: EBI-20562326; Score: 0.35
DE  Interaction: P35408; IntAct: EBI-20811489; Score: 0.37
DE  Interaction: P51957; IntAct: EBI-20721387; Score: 0.35
DE  Interaction: P05455; IntAct: EBI-20900824; Score: 0.40
DE  Interaction: Q02878; IntAct: EBI-20907504; Score: 0.40
DE  Interaction: O76021; IntAct: EBI-20920060; Score: 0.40
DE  Interaction: P50993; IntAct: EBI-20925034; Score: 0.40
DE  Interaction: Q12996; IntAct: EBI-20929904; Score: 0.40
DE  Interaction: Q9NPJ6; IntAct: EBI-25472202; Score: 0.27
DE  Interaction: Q14108; IntAct: EBI-21264396; Score: 0.35
DE  Interaction: Q96GC9; IntAct: EBI-21267986; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21302175; Score: 0.35
DE  Interaction: Q96AC1; IntAct: EBI-21387090; Score: 0.00
DE  Interaction: Q99459; IntAct: EBI-21387226; Score: 0.00
DE  Interaction: O60239; IntAct: EBI-21387213; Score: 0.00
DE  Interaction: Q96MT8; IntAct: EBI-21387200; Score: 0.00
DE  Interaction: P61764; IntAct: EBI-21387187; Score: 0.00
DE  Interaction: Q96BS2; IntAct: EBI-21387161; Score: 0.00
DE  Interaction: Q9BY11; IntAct: EBI-21387148; Score: 0.00
DE  Interaction: P13569; IntAct: EBI-25416349; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25637382; Score: 0.35
DE  Interaction: Q9Y5P2; IntAct: EBI-26354638; Score: 0.35
DE  Interaction: P06702; IntAct: EBI-27037935; Score: 0.37
DE  Interaction: Q13363; IntAct: EBI-27044482; Score: 0.35
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: A0A0H3NFP4; IntAct: EBI-27055788; Score: 0.27
DE  Interaction: A0A0H3NF08; IntAct: EBI-27055973; Score: 0.27
DE  Interaction: P63252; IntAct: EBI-28956270; Score: 0.27
DE  Interaction: P35226; IntAct: EBI-27108918; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: Q93009; IntAct: EBI-30842049; Score: 0.44
DE  Interaction: Q9NZR4; IntAct: EBI-29000642; Score: 0.35
DE  Interaction: P21709; IntAct: EBI-32720516; Score: 0.27
DE  Interaction: P29317; IntAct: EBI-32720711; Score: 0.27
DE  Interaction: P29320; IntAct: EBI-32720767; Score: 0.27
DE  Interaction: P21802; IntAct: EBI-32721907; Score: 0.27
DE  Interaction: Q06124; IntAct: EBI-32723738; Score: 0.27
DE  Interaction: P04629; IntAct: EBI-32724282; Score: 0.27
DE  Interaction: Q16620; IntAct: EBI-32724423; Score: 0.27
DE  Interaction: P16234; IntAct: EBI-32724889; Score: 0.27
DE  Interaction: P09619; IntAct: EBI-32724964; Score: 0.27
DE  Interaction: P34925; IntAct: EBI-32731802; Score: 0.27
DE  Interaction: Q6J9G0; IntAct: EBI-32731895; Score: 0.27
DE  Interaction: P38398; IntAct: EBI-34581773; Score: 0.35
GO  GO:0015629;
GO  GO:0030424;
GO  GO:1904115;
GO  GO:0009925;
GO  GO:0005604;
GO  GO:0005938;
GO  GO:0031252;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0005925;
GO  GO:0031673;
GO  GO:0030056;
GO  GO:0016021;
GO  GO:0005882;
GO  GO:0045111;
GO  GO:0016020;
GO  GO:0015630;
GO  GO:0035371;
GO  GO:0005635;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0030018;
GO  GO:0003779;
GO  GO:0005509;
GO  GO:0005178;
GO  GO:0008017;
GO  GO:0051010;
GO  GO:0008022;
GO  GO:0042803;
GO  GO:0005198;
GO  GO:0007155;
GO  GO:0048870;
GO  GO:0031122;
GO  GO:0007010;
GO  GO:0031581;
GO  GO:0007229;
GO  GO:0045104;
GO  GO:0030011;
GO  GO:0000226;
GO  GO:0009611;
GO  GO:0008090;
GO  GO:0042060;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250};
SQ  MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDT
SQ  LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLW
SQ  TQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE
SQ  KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETE
SQ  IPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVIC
SQ  EDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNEC
SQ  SSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFP
SQ  SGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN
SQ  HKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE
SQ  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH
SQ  IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPR
SQ  NSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ
SQ  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE
SQ  VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLK
SQ  DDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA
SQ  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN
SQ  RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA
SQ  TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK
SQ  EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT
SQ  LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPE
SQ  LRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQL
SQ  TLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILR
SQ  AAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQC
SQ  DLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIID
SQ  NNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYM
SQ  DANTGQRLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPSSFNKCHCGEPEHEE
SQ  TPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDSENILTNYEN
SQ  QSRVETNERANECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSF
SQ  NDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNPQVQYHNDKYISNTS
SQ  GEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCATPLLDETISASDYETSLLNDQQNNTGTDTDSDDD
SQ  FYDTPLFEDDDHDSLLLDGDDRDCLHPEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDF
SQ  LMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEE
SQ  YVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGGGIRDENGKPRCQNVAEDMDIQLCASILNENSDEN
SQ  ENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESE
SQ  KTFGPASISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHIICTEPDLIGKPAEE
SQ  SHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQ
SQ  FPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFT
SQ  DGPEKELDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSPLNDMIQSNDLCSKE
SQ  SISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQ
SQ  ALSPRSQEKEVQIPELSQVFVEDVKDILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQM
SQ  SDSSGVSPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEKRGITSKVLPLQLEN
SQ  IFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEGNYYSPNLETVKEIGLESSTVWASTLPRDEKLKDL
SQ  CNDFPSHLECTSGSKEMASGDSSTEQFSSELQQCLQHTEKMHEYLTLLQDMKPPLDNQESLDNNLEALKNQLRQLETFEL
SQ  GLAPIAVILRKDMKLAEEFLKSLPSDFPRGHVEELSISHQSLKTAFSSLSNVSSERTKQIMLAIDSEMSKLAVSHEEFLH
SQ  KLKSFSDWVSEKSKSVKDIEIVNVQDSEYVKKRLEFLKNVLKDLGHTKMQLETTAFDVQFFISEYAQDLSPNQSKQLLRL
SQ  LNTTQKCFLDVQESVTTQVERLETQLHLEQDLDDQKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELK
SQ  KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK
SQ  EETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG
SQ  TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS
SQ  LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKR
SQ  DGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK
SQ  NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL
SQ  SVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKM
SQ  KDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL
SQ  EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQP
SQ  SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGL
SQ  TSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKS
SQ  FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW
SQ  LVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL
SQ  TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC
SQ  EDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD
SQ  VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY
SQ  KEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI
SQ  QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDL
SQ  AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV
SQ  GRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTI
SQ  KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ
SQ  GLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQR
SQ  LLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI
SQ  EKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS
SQ  RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ
SQ  TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM
SQ  RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE
SQ  LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT
SQ  ICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT
SQ  GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK
SQ  IKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA
SQ  EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS
SQ  IDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQ
SQ  QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL
SQ  SEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQ
SQ  LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKS
SQ  AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV
SQ  FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWL
SQ  EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG
SQ  KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE
SQ  LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT
SQ  LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL
SQ  EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG
SQ  RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKS
SQ  RVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIED
SQ  EVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKML
SQ  RSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTT
SQ  PKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEI
SQ  QSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR
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