ID  Q03707;
PN  Inner nuclear membrane protein SRC1;
GN  SRC1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:16929305}; Multi-pass membrane protein {ECO:0000269|PubMed:16929305}. Note=Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle.
DR  UNIPROT: Q03707;
DR  UNIPROT: D6VZE1;
DR  UNIPROT: Q03712;
DR  PDB: 4XZR;
DR  Pfam: PF12949;
DR  Pfam: PF09402;
DE  Function: Plays a role in sister chromatid separation. {ECO:0000269|PubMed:11754482}.
DE  Reference Proteome: Yes;
DE  Interaction: P25491; IntAct: EBI-3766672; Score: 0.35
DE  Interaction: P38181; IntAct: EBI-10052689; Score: 0.37
DE  Interaction: P39929; IntAct: EBI-10052658; Score: 0.37
DE  Interaction: Q02821; IntAct: EBI-16159762; Score: 0.68
DE  Interaction: P48510; IntAct: EBI-394272; Score: 0.37
DE  Interaction: Q03406; IntAct: EBI-394275; Score: 0.37
DE  Interaction: Q12159; IntAct: EBI-795996; Score: 0.35
DE  Interaction: Q12066; IntAct: EBI-795996; Score: 0.35
DE  Interaction: Q12213; IntAct: EBI-795996; Score: 0.35
DE  Interaction: P06169; IntAct: EBI-795996; Score: 0.35
DE  Interaction: P53141; IntAct: EBI-7762064; Score: 0.40
DE  Interaction: Q06485; IntAct: EBI-8221070; Score: 0.22
DE  Interaction: Q04087; IntAct: EBI-2212766; Score: 0.40
DE  Interaction: P25651; IntAct: EBI-2212775; Score: 0.40
DE  Interaction: P80667; IntAct: EBI-7340507; Score: 0.31
DE  Interaction: P10591; IntAct: EBI-3773694; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3784072; Score: 0.35
DE  Interaction: P38788; IntAct: EBI-3791828; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3795791; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3801877; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3807844; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3826087; Score: 0.35
DE  Interaction: Q12329; IntAct: EBI-3829680; Score: 0.35
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0034399;
GO  GO:0003682;
GO  GO:0034087;
GO  GO:0043007;
GO  GO:0000070;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MNSDLEYLEDGFDPNSMKVATLRRILVENNVDFPSNARKNALVGLFDEKVKPQIPQLRKMYLNVRPSDEGIVKMDRPSSS
SQ  PSIASPRRSRRARREKSASPMAKQFKKNRILDDVSNDDDDDDDDDDDNDKKDDPLIVPSGTDTDEVDDEEDDVITSSSNK
SQ  SDTNDFQQNSDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKRKTSDLNQEHGNGSAILGKLSVK
SQ  TPIKNTNRKPVSMDNFNDSLTSSGTENDPFVPNIRHNPKELGTANGTGHSTPLSKLKVSASFADKLPQKEVPSTILVPEV
SQ  EQQEPSQSERTPSLFSSEGSGSESEAPLLPEITTPGPHQPMGNTSNNVVEMIDTDSSNLVSDEDEVLVPTRIETPQLPTE
SQ  KDVEKCEARVQELQEEVNEQLEHENGSEFDVKQGSGKVGNRHKFKRALKFLSKSLLALFLFCIFIVIPLLFGLWYREQRL
SQ  LIGYCGHEVPSHRVSGNSFEFIQKLDNLLQDYRPKCIPCPPNGICYPYLKLKCKPDYKLAPSRLDFLEIIPAQGKCVKDD
SQ  KKQQLVSEVVEKSLEFLRAKNAQISCGDGKDDIESGMTEDALYQIFNEARAPWIRDDEFEDLWIQVIKDLTEEPEILWRQ
SQ  LSPTDNNIGGNSNNIIKTNDVPRQKRHLPEKFISKTRNFRSTSKKYIGMKCRFEREIYQTYKKFQRPIWLMFLLIVISKV
SQ  IEIKLKNYYRKKARIEELVTQTMEKLKFQKIKSMSDPKENAYLSIVQLRDIFLSDIVDLKYKNQLWSEVVKYLEHNNSNI
SQ  KSNLTEIRGEIMKCWEWIGPMELNEPKDSAENKI
//