ID  Q04175;
PN  Importin beta SMX1;
GN  SXM1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm. Nucleus, nuclear pore complex.
DR  UNIPROT: Q04175;
DR  UNIPROT: D6VT29;
DR  Pfam: PF08506;
DR  Pfam: PF03810;
DR  PROSITE: PS50166;
DE  Function: Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of ribosomal proteins (RPL11, RPL16, RPL25, RPL31A), the poly(A)-binding protein PAB1, the HO endonuclease or the tRNA and snRNA chaperone LHP1. Indirectly involved in nuclear mRNA export through its PAB1 nuclear import activity. {ECO:0000269|PubMed:12684370, ECO:0000269|PubMed:15004228, ECO:0000269|PubMed:15769879, ECO:0000269|PubMed:16507575, ECO:0000269|PubMed:9238021, ECO:0000269|PubMed:9412461, ECO:0000269|PubMed:9817748}.
DE  Reference Proteome: Yes;
DE  Interaction: P14907; IntAct: EBI-1173446; Score: 0.40
DE  Interaction: P20676; IntAct: EBI-1173466; Score: 0.40
DE  Interaction: P25491; IntAct: EBI-3664452; Score: 0.35
DE  Interaction: P40477; IntAct: EBI-1173457; Score: 0.40
DE  Interaction: Q03900; IntAct: EBI-391536; Score: 0.37
DE  Interaction: Q08229; IntAct: EBI-391539; Score: 0.37
DE  Interaction: P16140; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P36144; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-792680; Score: 0.53
DE  Interaction: P10592; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P46654; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P26785; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P0C0W9; IntAct: EBI-792680; Score: 0.56
DE  Interaction: P41940; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P40495; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P33399; IntAct: EBI-792680; Score: 0.70
DE  Interaction: P33892; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P00549; IntAct: EBI-792680; Score: 0.35
DE  Interaction: P39715; IntAct: EBI-807214; Score: 0.53
DE  Interaction: P32357; IntAct: EBI-814816; Score: 0.27
DE  Interaction: P38697; IntAct: EBI-818076; Score: 0.27
DE  Interaction: P07702; IntAct: EBI-818099; Score: 0.27
DE  Interaction: P36000; IntAct: EBI-818671; Score: 0.27
DE  Interaction: Q03862; IntAct: EBI-820134; Score: 0.27
DE  Interaction: P53230; IntAct: EBI-854989; Score: 0.00
DE  Interaction: Q3E757; IntAct: EBI-1173432; Score: 0.40
DE  Interaction: P04456; IntAct: EBI-1173432; Score: 0.40
DE  Interaction: P87262; IntAct: EBI-1173432; Score: 0.40
DE  Interaction: P40525; IntAct: EBI-1173432; Score: 0.40
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: Q03833; IntAct: EBI-2883650; Score: 0.00
DE  Interaction: P53688; IntAct: EBI-2884674; Score: 0.00
DE  Interaction: P40564; IntAct: EBI-3657084; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3678289; Score: 0.35
DE  Interaction: P39987; IntAct: EBI-3703411; Score: 0.35
DE  Interaction: P52919; IntAct: EBI-7043004; Score: 0.35
DE  Interaction: P53131; IntAct: EBI-10903607; Score: 0.35
DE  Interaction: Q12531; IntAct: EBI-16292501; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0005634;
GO  GO:0061608;
GO  GO:0031267;
GO  GO:0006406;
GO  GO:0006606;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MVQEQAILSCIEQTMVADAKIIKEAEQQLFEFQKQPGFTSFLLNIVSDDNFALNVRLSSAIYLKNKIHRSWDTKREDGIK
SQ  ADEKLSIKERLIETLVKNCENNHIRPILTETINGILVGQEDWDLAPIIKNLLSSGDASYIYPGLLLLFQLCKAHRWDMVG
SQ  SRDYIDSVIEELFPIVEGIASNIGSQTDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMSWVQLHLYLCSKPLPVEVM
SQ  ELDPADRSLDKRVKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSDSSLYFLI
SQ  SFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPE
SQ  KLNNILPFINDIFTRFDANSSDINMAFKEEGALRTLSNLFSFIDEPSVLENIFGHFIVPLLSQDKYMFLVARSLETIALY
SQ  SEEFKDMNILSQLFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVSAHVPGMMEKLLKLSKIFEIDILSEVMEA
SQ  LVERFSDELSPFAKDLASNLVEQFLRIAQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFV
SQ  VLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELLHDILDSFQTYAMDYFEAYSIFFETIVMTGFPQDQTYVQPLLE
SQ  ILSAKLESEVDYDIEHVMQILMYFALSMRDIPLFSKAIKVSTNDELGLDSKCIVKLGLANLFAKPIETLQIMENEGFTIN
SQ  FFTNWFNEKFYSVFAIKLQVLVILTLLKMPEVPNSVSPLLNNLTNKLVELTLSLPKAIRNRDAVTEGKSLEGDLTPEEEE
SQ  EYFIECDDDMKETVLDQINVFQEVHTFFKNLQNEDAGKYEKIINYLDESKRDSLQVILEFVSQH
//