ID  Q04431;
PN  Spindle pole body component KRE28;
GN  KRE28;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Chromosome, centromere, kinetochore. Note=Localizes to the nuclear side of the spindle pole body.
DR  UNIPROT: Q04431;
DR  UNIPROT: D6VTF3;
DR  UNIPROT: Q6Q537;
DR  Pfam: PF17097;
DE  Function: Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint. {ECO:0000269|PubMed:19893618}.
DE  Reference Proteome: Yes;
DE  Interaction: P25491; IntAct: EBI-3664804; Score: 0.35
DE  Interaction: P53148; IntAct: EBI-7384815; Score: 0.66
DE  Interaction: P32361; IntAct: EBI-390519; Score: 0.37
DE  Interaction: P53743; IntAct: EBI-861238; Score: 0.00
DE  Interaction: P40568; IntAct: EBI-1543715; Score: 0.35
DE  Interaction: P39731; IntAct: EBI-1543771; Score: 0.35
DE  Interaction: P40460; IntAct: EBI-2343287; Score: 0.37
DE  Interaction: Q07978; IntAct: EBI-2344403; Score: 0.37
DE  Interaction: P28004; IntAct: EBI-2344578; Score: 0.37
DE  Interaction: P43592; IntAct: EBI-2344838; Score: 0.37
DE  Interaction: P11484; IntAct: EBI-3698908; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3717706; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3722662; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3731786; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3753047; Score: 0.35
DE  Interaction: P25300; IntAct: EBI-16253676; Score: 0.00
GO  GO:0000775;
GO  GO:0005737;
GO  GO:0000776;
GO  GO:0031965;
GO  GO:0005816;
GO  GO:0051382;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MDTGSASIKDYETVLTDIEDSIAVSSEEVLNNQELRLKNTLHEITSSILAINEENKFVNPLRNDESLDVEGKEVFVNPKI
SQ  LSAKIKEFNKLMELLKLTYLEQETLDYFFRFTLSSTKPLQLDSEKDPQFVKLNERVNDLKEEISNVQESKIEQIKAEIQE
SQ  TGHNFAERQDLINELYLEATGDIENCWDSLNELKNLTNKEDKNMMGEKDTILNSSDSDDFVEETYTNWQKLLFLQKQNQR
SQ  LTKELKEMHEVKNQIIRKGEQSKKEDSGHLMANESELCQSINLLTKFWEKHFLLKGSKTTILNFEIFTQLGKVQFEIKDM
SQ  QYIIAISLSDLKRPMIKDITILQKAGGNIVTDIEASSKFNNKYRNNTKVQIFEVMDDIISELTNE
//