ID  Q04746;
PN  Nuclear fusion protein KAR5;
GN  KAR5;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
DR  UNIPROT: Q04746;
DR  UNIPROT: D6VZN9;
DR  Pfam: PF04163;
DE  Function: Required for nuclear membrane fusion during karyogamy. {ECO:0000269|PubMed:10069807, ECO:0000269|PubMed:8051211, ECO:0000269|PubMed:9382856, ECO:0000269|PubMed:9456310}.
DE  Reference Proteome: Yes;
DE  Interaction: P41901; IntAct: EBI-599525; Score: 0.37
DE  Interaction: P38989; IntAct: EBI-599534; Score: 0.37
DE  Interaction: P47037; IntAct: EBI-599543; Score: 0.37
DE  Interaction: Q06179; IntAct: EBI-599561; Score: 0.37
DE  Interaction: P39013; IntAct: EBI-599570; Score: 0.37
DE  Interaction: P40073; IntAct: EBI-7768639; Score: 0.37
DE  Interaction: Q07914; IntAct: EBI-857938; Score: 0.00
DE  Interaction: Q02159; IntAct: EBI-859813; Score: 0.00
DE  Interaction: P38788; IntAct: EBI-3790287; Score: 0.35
DE  Interaction: P15108; IntAct: EBI-3809587; Score: 0.35
GO  GO:0005789;
GO  GO:0031301;
GO  GO:0005739;
GO  GO:0031965;
GO  GO:0000742;
GO  GO:0048288;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MFEMRYVYLFAICIKFVSSSELGKINNLLQGRLIYTDNSVATNVLESKFPFLKSTCVKDALKLFLPQCIANGLESIDAET
SQ  RVETAIKLSICEFQASGLGEIPENCMVDDLGSMMDCMFELESSSQWWTTYSGNYQRLSSICYENLLPFEKEQILKLFLNI
SQ  TELYDSFGDDVDTKLNHLMFQMEQDSQNFLDDLARMFRNYDNELRNATESNRIILENDLSFFRNKVNDVLYETSEQLEVQ
SQ  IIEKNSQLMNEVDTVHHIMSDLADELAKNDIKSKINDLKDDSLNNLQDLVEMSNDVKEYYSRNNKLVNTELENFSMGLKK
SQ  QLGGMSKDLSESQMEAIELLQGFNSILHDSLLPSMTDEIVPEMTNFKNTLLQEWTAITSTLNGDFALWNEEIFSTFNDIS
SQ  EKLNGTKKKLDDIEIRVSLVHKNVMTMMRVLDFMWKTSKMIIRCGYLAVKNKYYWLLCSVVWIWSKYRTSRVNVKMIPIK
SQ  RYYQWAALLLSIYLGAKTGSLIDF
//