ID  Q06148;
PN  Non-homologous end-joining protein 1;
GN  NEJ1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
DR  UNIPROT: Q06148;
DR  UNIPROT: D6VYR3;
DR  UNIPROT: Q0P6Z6;
DR  UNIPROT: Q0P6Z7;
DR  UNIPROT: Q0P707;
DR  Pfam: PF09302;
DE  Function: Involved in non-homologous end joining (NHEJ). Facilitates the transport of LIF1 into the nucleus, where it can interact with DNA ligase DNL4 to repair double-strand breaks (DSB). Mediates mating-type regulation of NHEJ. Prevents chromosome circularisation by NHEJ in absence of telomerase. {ECO:0000269|PubMed:11676923, ECO:0000269|PubMed:11701889, ECO:0000269|PubMed:11711435, ECO:0000269|PubMed:11740566, ECO:0000269|PubMed:12399380, ECO:0000269|PubMed:12769859}.
DE  Reference Proteome: Yes;
DE  Interaction: P38316; IntAct: EBI-858184; Score: 0.00
DE  Interaction: P42940; IntAct: EBI-7857152; Score: 0.40
DE  Interaction: P50277; IntAct: EBI-8220972; Score: 0.22
DE  Interaction: P53150; IntAct: EBI-1567366; Score: 0.65
DE  Interaction: P25294; IntAct: EBI-3661323; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3712698; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3727166; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3781470; Score: 0.35
DE  Interaction: P12954; IntAct: EBI-15792132; Score: 0.53
GO  GO:0005737;
GO  GO:0032807;
GO  GO:0016021;
GO  GO:0070419;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0045027;
GO  GO:0006303;
GO  GO:0045002;
GO  GO:0035825;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDSELKGQQLSDAEWCVKKINGEGNCLLLFLPMSSPTTIVMIVLVSLERLVPYVFKLSQTQLSQQCQSQGFTDSISLNLI
SQ  KLKLMDILQAPQEINQIGLVDSNLVFSFDVSADITVSINSVPSHVTKDMFYMILQSLCMLLLKLVNLSTQYHYVQRDILN
SQ  EKQKCLDFLLISLRDLDGGSKVISQWAPENSKNYESLQQCTDDDIIKKLLHKGKFQHQEFLADSLKTLLSLRNKFQDVSR
SQ  FEESGELNKKERVRFPAVNHFYNDDFELQADPTNEARPNSRGKIKPKTDFKPKSRESSTSSQLRLENFSESEATPEKTKS
SQ  SSSLVEEYPQKKRKFGKVRIKN
//