ID  Q06833;
PN  Nucleus-vacuole junction protein 2;
GN  NVJ2;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Single-pass type II membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:22250200}; Single- pass type II membrane protein {ECO:0000305}. Note=Enriched at the nucleus-vacuole junction where it becomes increasingly concentrated as cells enter into the late-logarithmic growth phase (PubMed:22250200). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (PubMed:28011845). {ECO:0000269|PubMed:22250200, ECO:0000269|PubMed:28011845}.
DR  UNIPROT: Q06833;
DR  UNIPROT: D6W491;
DR  Pfam: PF10296;
DR  Pfam: PF00169;
DR  PROSITE: PS51847;
DE  Function: During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, induces contacts between the ER and medial- Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
DE  Reference Proteome: Yes;
DE  Interaction: P39743; IntAct: EBI-7295400; Score: 0.65
DE  Interaction: P43603; IntAct: EBI-489033; Score: 0.00
DE  Interaction: Q02159; IntAct: EBI-860443; Score: 0.00
DE  Interaction: P47068; IntAct: EBI-7295421; Score: 0.44
DE  Interaction: P0CF34; IntAct: EBI-7295458; Score: 0.44
DE  Interaction: P80667; IntAct: EBI-7296890; Score: 0.44
DE  Interaction: P32790; IntAct: EBI-7310006; Score: 0.31
DE  Interaction: P10591; IntAct: EBI-3682273; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3719222; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3786837; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3803850; Score: 0.35
GO  GO:0071944;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0071561;
GO  GO:0008289;
GO  GO:0035621;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MASLKVFLAVYLLGGITFLPLVLFTLYKIHLLYSNLKSASKKELDHDTADEIDEKTRLLARDIDPEFKARKLEEQLGVKV
SQ  FNKGWITVTKQYYYHSSEVAVILKNSNNNKDSDTALQEQILQRTDLKKKQRFFAVLRHGNLFLYKDDSQNANLVHAISLQ
SQ  NRFITIWPRFDELGKEELPDASLFTKRTCIAIFKNDLVSIDSKNHNVILPHFDPLTSAESNNGDISTNDTTHEYQSQFHS
SQ  SNQFFLYFDNNMDKEDWYYQLINASKNSNSLSTGLLDPNVSANAAHLKTKDMLQLIQDINSTENQLTTKWLNALLGRLFL
SQ  SLQQTDTLNKFIHEKICKKLNKIKTPGFLDDLVVEKVDVGDSAPLFTSPELLELSPEGSTKIAIDVQYRGNLTIIIATKA
SQ  SINLGSRFKQREVSLQLSIKIKEFSGPLLFLIKPPPSNRIWYAFRTEPIMDFEIEPIVSSSKLSYNVVTNAIKSKFAEAV
SQ  KESLVVPFMDDIVFYPTPNEVYRGGIWEEQDPEAAARARTAAAASDMNNTSAKEHLEALQEGGMKTQSRIKKALRPERKK
SQ  ENLKDLVDASGVATKTTTQTTVTTATNDDVSSSENSTKSRKYFKNSIKKIGRWYKDNVGNSSDTEDMDEIDVQDKKNDDS
SQ  ADERESDNPILTSNPKMISNRRPVPRRPSQPLNTLSPKLEGRKEKDTENFPVPPSASNMNASKMFANKENRKFSVSSNDS
SQ  QNSLKNGDPHVKASKLESSQAFVKKTSQNRFNDGFFKQDLEFEEQREPKL
//