ID  Q07065;
PN  Cytoskeleton-associated protein 4;
GN  CKAP4;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
DR  UNIPROT: Q07065;
DR  UNIPROT: Q504S5;
DR  UNIPROT: Q53ES6;
DR  OMIM: 618595;
DR  DisGeNET: 10970;
DE  Function: Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}. High-affinity epithelial cell surface receptor for the FZD8- related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}.
DE  Reference Proteome: Yes;
DE  Interaction: A0A142I5B9; IntAct: EBI-20626314; Score: 0.35
DE  Interaction: O43542; IntAct: EBI-11129266; Score: 0.35
DE  Interaction: O76050; IntAct: EBI-20901648; Score: 0.40
DE  Interaction: P00519; IntAct: EBI-10101379; Score: 0.35
DE  Interaction: P00533; IntAct: EBI-702075; Score: 0.35
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: Q9H1I8; IntAct: EBI-733925; Score: 0.00
DE  Interaction: P49407; IntAct: EBI-1642094; Score: 0.35
DE  Interaction: Q70EL3; IntAct: EBI-2512984; Score: 0.40
DE  Interaction: P40692; IntAct: EBI-2932395; Score: 0.37
DE  Interaction: Q8IYT8; IntAct: EBI-2984710; Score: 0.35
DE  Interaction: P60520; IntAct: EBI-3046676; Score: 0.35
DE  Interaction: P01106; IntAct: EBI-3893169; Score: 0.35
DE  Interaction: P18848; IntAct: EBI-3927782; Score: 0.37
DE  Interaction: P17568; IntAct: EBI-3936336; Score: 0.37
DE  Interaction: Q99598; IntAct: EBI-3936346; Score: 0.37
DE  Interaction: Q14764; IntAct: EBI-3936356; Score: 0.37
DE  Interaction: Q07065; IntAct: EBI-3942157; Score: 0.37
DE  Interaction: Q9Y3C0; IntAct: EBI-3942167; Score: 0.37
DE  Interaction: P81172; IntAct: EBI-3942177; Score: 0.37
DE  Interaction: Q6I9Y2; IntAct: EBI-3942193; Score: 0.37
DE  Interaction: P04578; IntAct: EBI-6174316; Score: 0.46
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: P63208; IntAct: EBI-8835658; Score: 0.35
DE  Interaction: O75807; IntAct: EBI-9976880; Score: 0.35
DE  Interaction: O60307; IntAct: EBI-10103761; Score: 0.35
DE  Interaction: Q96FW1; IntAct: EBI-10770198; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: P36895; IntAct: EBI-11008521; Score: 0.35
DE  Interaction: P35278; IntAct: EBI-11012136; Score: 0.35
DE  Interaction: Q3UJU9; IntAct: EBI-11021410; Score: 0.35
DE  Interaction: O75787; IntAct: EBI-11037152; Score: 0.35
DE  Interaction: P51148; IntAct: EBI-11046231; Score: 0.35
DE  Interaction: P51149; IntAct: EBI-11050319; Score: 0.35
DE  Interaction: Q9D8B3; IntAct: EBI-11052854; Score: 0.35
DE  Interaction: Q16513; IntAct: EBI-11070511; Score: 0.35
DE  Interaction: F8VQC7; IntAct: EBI-11104527; Score: 0.35
DE  Interaction: Q9R0Q3; IntAct: EBI-11111571; Score: 0.35
DE  Interaction: Q9P0L0; IntAct: EBI-11120309; Score: 0.35
DE  Interaction: P09450; IntAct: EBI-11127973; Score: 0.35
DE  Interaction: Q15006; IntAct: EBI-11130215; Score: 0.35
DE  Interaction: Q8N4V1; IntAct: EBI-11130635; Score: 0.35
DE  Interaction: O00400; IntAct: EBI-11135399; Score: 0.35
DE  Interaction: Q5T3F8; IntAct: EBI-11155257; Score: 0.35
DE  Interaction: Q9Y3E0; IntAct: EBI-11161387; Score: 0.35
DE  Interaction: Q2MV58; IntAct: EBI-11366929; Score: 0.27
DE  Interaction: Q5HYA8; IntAct: EBI-11367583; Score: 0.27
DE  Interaction: Q6NUS6; IntAct: EBI-11368748; Score: 0.27
DE  Interaction: Q86UK5; IntAct: EBI-11372136; Score: 0.27
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q96GX1; IntAct: EBI-11375285; Score: 0.27
DE  Interaction: Q96Q45; IntAct: EBI-11377173; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11378021; Score: 0.27
DE  Interaction: Q99IB8; IntAct: EBI-11613941; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q13503; IntAct: EBI-21501670; Score: 0.35
DE  Interaction: P30825; IntAct: EBI-21505748; Score: 0.35
DE  Interaction: Q92633; IntAct: EBI-21508694; Score: 0.35
DE  Interaction: Q9H8X2; IntAct: EBI-21509881; Score: 0.35
DE  Interaction: Q16581; IntAct: EBI-21515265; Score: 0.35
DE  Interaction: Q6P5W5; IntAct: EBI-21515976; Score: 0.35
DE  Interaction: Q9UGM1; IntAct: EBI-21517134; Score: 0.35
DE  Interaction: A2A2Y4; IntAct: EBI-21527504; Score: 0.35
DE  Interaction: O75326; IntAct: EBI-21558128; Score: 0.35
DE  Interaction: O95274; IntAct: EBI-21607810; Score: 0.35
DE  Interaction: Q99689; IntAct: EBI-21638763; Score: 0.35
DE  Interaction: O94766; IntAct: EBI-21668731; Score: 0.35
DE  Interaction: Q99871; IntAct: EBI-21670231; Score: 0.35
DE  Interaction: Q9NVF7; IntAct: EBI-21671334; Score: 0.35
DE  Interaction: Q7LGA3; IntAct: EBI-21675787; Score: 0.35
DE  Interaction: Q16322; IntAct: EBI-21690666; Score: 0.35
DE  Interaction: P49796; IntAct: EBI-21716735; Score: 0.35
DE  Interaction: Q86Y78; IntAct: EBI-21717654; Score: 0.35
DE  Interaction: O14763; IntAct: EBI-21722795; Score: 0.35
DE  Interaction: Q8WWF3; IntAct: EBI-21811588; Score: 0.35
DE  Interaction: P08842; IntAct: EBI-21852400; Score: 0.35
DE  Interaction: P51888; IntAct: EBI-21852864; Score: 0.35
DE  Interaction: Q9Y6Z7; IntAct: EBI-21859525; Score: 0.35
DE  Interaction: Q9BZR6; IntAct: EBI-21865956; Score: 0.35
DE  Interaction: Q5BJH7; IntAct: EBI-21881931; Score: 0.35
DE  Interaction: P50876; IntAct: EBI-21881918; Score: 0.40
DE  Interaction: O60858; IntAct: EBI-21881893; Score: 0.35
DE  Interaction: O15155; IntAct: EBI-16788067; Score: 0.27
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.42
DE  Interaction: Q96I36; IntAct: EBI-16791250; Score: 0.27
DE  Interaction: P13073; IntAct: EBI-16791533; Score: 0.27
DE  Interaction: P11279; IntAct: EBI-16794808; Score: 0.27
DE  Interaction: Q9HBL7; IntAct: EBI-16797780; Score: 0.27
DE  Interaction: P51151; IntAct: EBI-16798325; Score: 0.27
DE  Interaction: Q9NS69; IntAct: EBI-16802054; Score: 0.27
DE  Interaction: O43493; IntAct: EBI-16800982; Score: 0.42
DE  Interaction: P36957; IntAct: EBI-20305285; Score: 0.35
DE  Interaction: P08559; IntAct: EBI-20306509; Score: 0.35
DE  Interaction: P31040; IntAct: EBI-20306992; Score: 0.35
DE  Interaction: Q9UKU6; IntAct: EBI-20901800; Score: 0.40
DE  Interaction: Q8WXX0; IntAct: EBI-20901792; Score: 0.40
DE  Interaction: P04275; IntAct: EBI-20903352; Score: 0.40
DE  Interaction: P29475; IntAct: EBI-20905832; Score: 0.40
DE  Interaction: Q6NUK1; IntAct: EBI-20909712; Score: 0.40
DE  Interaction: Q8IVJ8; IntAct: EBI-20910272; Score: 0.40
DE  Interaction: Q96NB3; IntAct: EBI-20910632; Score: 0.40
DE  Interaction: P21675; IntAct: EBI-20917908; Score: 0.40
DE  Interaction: P16403; IntAct: EBI-20926338; Score: 0.40
DE  Interaction: A6NNW6; IntAct: EBI-20932560; Score: 0.40
DE  Interaction: Q9ULG1; IntAct: EBI-20935724; Score: 0.40
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: P62079; IntAct: EBI-20977847; Score: 0.35
DE  Interaction: O95858; IntAct: EBI-20977902; Score: 0.35
DE  Interaction: Q15077; IntAct: EBI-21262943; Score: 0.35
DE  Interaction: Q9H1C4; IntAct: EBI-21266770; Score: 0.35
DE  Interaction: P25100; IntAct: EBI-21277437; Score: 0.35
DE  Interaction: Q00059; IntAct: EBI-21980665; Score: 0.35
DE  Interaction: O84793; IntAct: EBI-22302936; Score: 0.35
DE  Interaction: Q640N3; IntAct: EBI-25409042; Score: 0.35
DE  Interaction: Q5FWK3; IntAct: EBI-25409394; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P23497; IntAct: EBI-25485215; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25636144; Score: 0.35
DE  Interaction: P0DTD8; IntAct: EBI-25687199; Score: 0.35
DE  Interaction: Q7TFA1; IntAct: EBI-25688644; Score: 0.35
DE  Interaction: P02452; IntAct: EBI-26366205; Score: 0.35
DE  Interaction: Q53F19; IntAct: EBI-26396827; Score: 0.35
DE  Interaction: P52298; IntAct: EBI-26398473; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-26610886; Score: 0.35
DE  Interaction: Q8NDZ4; IntAct: EBI-26597064; Score: 0.35
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: Q13363; IntAct: EBI-27044482; Score: 0.35
DE  Interaction: A0A0H3NFP4; IntAct: EBI-27055788; Score: 0.27
DE  Interaction: A0A0H3NG92; IntAct: EBI-27055968; Score: 0.27
DE  Interaction: A0A0H3NF08; IntAct: EBI-27055973; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: P35226; IntAct: EBI-27108918; Score: 0.35
DE  Interaction: Q99592; IntAct: EBI-27093179; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: Q8NCK7; IntAct: EBI-27105115; Score: 0.35
DE  Interaction: P56180; IntAct: EBI-27116883; Score: 0.27
DE  Interaction: P0DTC4; IntAct: EBI-28955127; Score: 0.35
DE  Interaction: P08069; IntAct: EBI-32718669; Score: 0.35
DE  Interaction: P08922; IntAct: EBI-32719572; Score: 0.35
DE  Interaction: Q5JZY3; IntAct: EBI-32720634; Score: 0.27
DE  Interaction: P29322; IntAct: EBI-32721175; Score: 0.27
DE  Interaction: P54760; IntAct: EBI-32721396; Score: 0.27
DE  Interaction: P21860; IntAct: EBI-32721529; Score: 0.27
DE  Interaction: P06213; IntAct: EBI-32723092; Score: 0.27
DE  Interaction: P14616; IntAct: EBI-32723232; Score: 0.27
DE  Interaction: O15146; IntAct: EBI-32724025; Score: 0.27
DE  Interaction: P04629; IntAct: EBI-32724282; Score: 0.27
DE  Interaction: P16234; IntAct: EBI-32724889; Score: 0.27
DE  Interaction: P09619; IntAct: EBI-32724964; Score: 0.27
DE  Interaction: P07949; IntAct: EBI-32725031; Score: 0.27
DE  Interaction: Q04912; IntAct: EBI-32725158; Score: 0.27
DE  Interaction: Q6J9G0; IntAct: EBI-32731895; Score: 0.27
DE  Interaction: Q8TCJ2; IntAct: EBI-32732289; Score: 0.27
GO  GO:0035577;
GO  GO:0005856;
GO  GO:0005783;
GO  GO:0005788;
GO  GO:0005789;
GO  GO:0070062;
GO  GO:0016021;
GO  GO:0042599;
GO  GO:0005811;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005791;
GO  GO:0035579;
GO  GO:0003723;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSS
SQ  SSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQ
SQ  KVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEER
SQ  LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESD
SQ  IYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFE
SQ  ALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL
SQ  VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSL
SQ  VAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV
//