ID  Q07878;
PN  Intermembrane lipid transfer protein VPS13;
GN  VPS13;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Endosome membrane {ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:28334785, ECO:0000269|PubMed:28864540, ECO:0000269|PubMed:30018089, ECO:0000269|PubMed:32690699, ECO:0000305|PubMed:22442115, ECO:0000305|PubMed:24036347}; Peripheral membrane protein {ECO:0000269|PubMed:28122955}. Mitochondrion outer membrane {ECO:0000269|PubMed:26370498, ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:30018089, ECO:0000269|PubMed:34830155}; Peripheral membrane protein {ECO:0000269|PubMed:28122955}. Prospore membrane {ECO:0000269|PubMed:22442115, ECO:0000269|PubMed:24036347, ECO:0000269|PubMed:27280386}; Peripheral membrane protein {ECO:0000269|PubMed:28122955}. Vacuole membrane {ECO:0000269|PubMed:26370498, ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:30018089, ECO:0000269|PubMed:32690699}; Peripheral membrane protein {ECO:0000269|PubMed:28122955}. Nucleus outer membrane {ECO:0000269|PubMed:26370498, ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:30018089}; Peripheral membrane protein {ECO:0000269|PubMed:28122955}. Peroxisome {ECO:0000269|PubMed:28864540}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:34830155}; Peripheral membrane protein {ECO:0000269|PubMed:28122955}. Note=Found at different interorganellar contact sites depending on the growth state of the cell (PubMed:26370498, PubMed:27280386, PubMed:30018089, PubMed:32690699). Localizes from endosomes to the vacuolar membrane during starvation (PubMed:32690699). Localizes to mitochondrial-endosome contacts (PubMed:27280386). Localizes to nuclear envelope-vacuole contact sites (nuclear-vacuole junction; NVJ) during respiration (PubMed:26370498, PubMed:27280386, PubMed:30018089). {ECO:0000269|PubMed:26370498, ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:30018089, ECO:0000269|PubMed:32690699}.
DR  UNIPROT: Q07878;
DR  UNIPROT: D6VXW6;
DR  UNIPROT: O00040;
DR  Pfam: PF12624;
DR  Pfam: PF06650;
DR  Pfam: PF16908;
DR  Pfam: PF16909;
DR  Pfam: PF16910;
DE  Function: Mediates the transfer of lipids between membranes at organelle contact sites (PubMed:30093493, PubMed:24036347, PubMed:22442115). Binds phospholipids, including phosphatidic acid (PA), phosphorylated phosphatidylinositol (PI), phosphatidylcholine (PC), phosphatidylethanolamine (PE), ceramide, and phosphatidylserine (PS) (PubMed:30093493, PubMed:34830155, PubMed:28122955, PubMed:28334785). Involved in mitochondrial lipid homeostasis, in a MCP1-dependent manner (PubMed:27280386, PubMed:34830155, PubMed:32690699). Involved in cortical reticulophagy (also known as cortical endoplasmic reticulum (ER) macroautophagy), acting at the late endosome to package ER into autophagosomes (PubMed:32690699). Involved in the formation of the prospore membrane during sporulation, in a SPO71-dependent manner (PubMed:24036347, PubMed:22442115). Involved in Golgi vesicle transport, in a CDC31-dependent and ARF1-dependent manner (PubMed:28122955, PubMed:9314526, PubMed:34830155). Plays a role in actin cytoskeleton organization (PubMed:28334785). {ECO:0000269|PubMed:22442115, ECO:0000269|PubMed:24036347, ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:28122955, ECO:0000269|PubMed:28334785, ECO:0000269|PubMed:30093493, ECO:0000269|PubMed:32690699, ECO:0000269|PubMed:34830155, ECO:0000269|PubMed:9314526}.
DE  Reference Proteome: Yes;
DE  Interaction: P30656; IntAct: EBI-7116059; Score: 0.40
DE  Interaction: P23639; IntAct: EBI-7116127; Score: 0.40
DE  Interaction: P49956; IntAct: EBI-785954; Score: 0.44
DE  Interaction: P16140; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P09733; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P10659; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P40495; IntAct: EBI-797353; Score: 0.35
DE  Interaction: P06787; IntAct: EBI-797353; Score: 0.53
DE  Interaction: P16550; IntAct: EBI-799867; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P17255; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P38764; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P41940; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P16474; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P14742; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P43535; IntAct: EBI-800803; Score: 0.35
DE  Interaction: P32324; IntAct: EBI-800803; Score: 0.35
DE  Interaction: Q00955; IntAct: EBI-812797; Score: 0.27
DE  Interaction: P18239; IntAct: EBI-813508; Score: 0.27
DE  Interaction: P37898; IntAct: EBI-813689; Score: 0.27
DE  Interaction: P60010; IntAct: EBI-820657; Score: 0.27
DE  Interaction: Q12250; IntAct: EBI-7638438; Score: 0.40
DE  Interaction: P38236; IntAct: EBI-8445626; Score: 0.44
DE  Interaction: P38041; IntAct: EBI-7370461; Score: 0.37
DE  Interaction: Q08273; IntAct: EBI-16271112; Score: 0.35
DE  Interaction: P06244; IntAct: EBI-16285450; Score: 0.35
DE  Interaction: P38815; IntAct: EBI-16289368; Score: 0.40
GO  GO:0005768;
GO  GO:0010008;
GO  GO:0019898;
GO  GO:0005794;
GO  GO:0005798;
GO  GO:0031966;
GO  GO:0005741;
GO  GO:0005739;
GO  GO:0005640;
GO  GO:0071561;
GO  GO:0005777;
GO  GO:0005628;
GO  GO:0005774;
GO  GO:0005773;
GO  GO:1990816;
GO  GO:0008289;
GO  GO:0005543;
GO  GO:0120014;
GO  GO:0032120;
GO  GO:0048193;
GO  GO:0120009;
GO  GO:0045324;
GO  GO:0007005;
GO  GO:0045053;
GO  GO:0006623;
GO  GO:0090083;
GO  GO:0061709;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:28122955};
SQ  MLESLAANLLNRLLGSYVENFDPNQLNVGIWSGDVKLKNLKLRKDCLDSLNLPIDVKSGILGDLVLTVPWSSLKNKPVKI
SQ  IIEDCYLLCSPRSEDHENDEEMIKRAFRLKMRKVSEWELTNQARILSTQSENKTSSSSSEKNNAGFMQSLTTKIIDNLQV
SQ  TIKNIHLRYEDMDGIFTTGPSSVGLTLNELSAVSTDSNWAPSFIDITQNITHKLLTLNSLCLYWNTDSPPLISDDDQDRS
SQ  LENFVRGFKDMIASKNSTAPKHQYILKPVSGLGKLSINKLGSTEEQPHIDLQMFYDEFGLELDDTEYNDILHVLSSIQLR
SQ  QITKKFKKARPSFAVSENPTEWFKYIAACVINEIHEKNKMWTWESMKEKCEQRRLYTKLWVEKLKLKNLEAPLRDPIQEA
SQ  QLSELHKDLTYDEIILFRSVAKRQYAQYKLGMTEDSPTPTASSNIEPQTSNKSATKNNGSWLSSWWNGKPTEEVDEDLIM
SQ  TEEQRQELYDAIEFDENEDKGPVLQVPRERVELRVTSLLKKGSFTIRKKKQNLNLGSIIFENCKVDFAQRPDSFLSSFQL
SQ  NKFSLEDGSPNALYKHIISVRNSSKDQSSIDNHATGEEEEEDEPLLRASFELNPLDGLADSNLNIKLLGMTVFYHVHFIT
SQ  EVHKFFKASNQHMETIGNIVNAAEATVEGWTTQTRMGIESLLEDHKTVNVSLDLQAPLIILPLDPHDWDTPCAIIDAGHM
SQ  SILSDLVPKEKIKEIKELSPEEYDKIDGNEINRLMFDRFQILSQDTQIFVGPDIQSTIGKINTASSTNDFRILDKMKLEL
SQ  TVDLSILPKAYKLPTIRVFGHLPRLSLSINDIQYKTIMNLIANSIPSMIDDEENNGDYVNYSSGSEKEMKKQIQLQLKNT
SQ  LKALENMQPLQIEQKFLELHFDIDQAKIAFFQCIKNDSRNSEKLVDILCQRLNFNFDKRAKEMNLDLRVHSLDVEDYIEL
SQ  TDNKEFKNLISSGVEKVTRSQKDLFTLKYKRVQRIVPHNDTLIELFDQDIVMHMSELQLVLTPRSVLTLMNYAMLTFTDP
SQ  NAPEMPADVLRHNKEDRDDAPQKINMKIKMEAVNVIFNDDSIKLATLVLSAGEFTMVLLPERYNINLKLGGLELTDETNE
SQ  SFSRDSVFRKIIQMKGQELVELSYESFDPATNTKDYDSFLKYSTGSMHVNFIESAVNRMVNFFAKFQKSKVSFDRARLAA
SQ  YNQAPSIDAVNNMKMDIVIKAPIIQFPKLVGTQENNYDTMRFYLGEFFIENKFSVIDESHKINHIKLGVREGQLSSNLNF
SQ  DGSSQQLYLVENIGLLFNIDRDPLPQDDTPELKVTSNFESFALDLTENQLTYLLEISNKVSSAFNITDENSGESGGKGEI
SQ  KSPSPDPASLSSESERTATPQSLQGSNKSNIKNPEQKYLDFSFKAPKIALTLYNKTKGVTSLNDCGLTRIMFQDIGCSLG
SQ  LKNDGTVDGQAHVAAFRIEDVRNIKDNKHTELIPKSKNKEYQFVANISRKNLEVGRLLNISMTMDSPKMILAMDYLVSLK
SQ  EFFDAIMSKSHENNLYYPENTNQKPENKAIVESVQEGGDVTKIQYSVNIIETALILLADPCDMNSEAISFKIGQFLVTDQ
SQ  NIMTVAANNVGIFLFKMNSSEEKLRLLDDFSSSLTIDKRNSTPQTLMTNIQLSVQPLLMRISLRDIRLAMLIFKRVTTLL
SQ  NKMTEKEDNGEEEESTDKIQFSHEFERKLAVLDPSILGERSRASQSSDSESIEVPTAILKNETFNADLGGLRFILIGDVH
SQ  EMPILDMNVNEITASAKDWSTDFEALASLETYVNIFNYSRSSWEPLLEMIPITFHLSKGHSEMDPAFSFDILTQRIAEIT
SQ  LSARSIAMLSHIPASLTEELPLASRVSQKPYQLVNDTELDFDVWIQDKTTEDNKNEVVLLKANTSLPWEFEDWRSIREKL
SQ  DIDKSKNILGVCVSGQNYKTIMNIDATTEGENLHVLSPPRNNVHNRIVCEARCDENNVKIITFRSTLVIENTTSTEIELL
SQ  VDSKDPNKPSLKYAIKPHQSKSVPVEYAYDSDIRIRPASEDIYDWSQQTLSWKSLLSNQMSIFCSSKEDSNQRFHFEIGA
SQ  KYDEREPLAKIFPHMKIVVSASMTIENLLPADINFSIFDKREEKRTDFLKTGESMEVHHISLDSFLLMSVQPLQDEASAS
SQ  KPSIVNTPHKSPLNPEDSLSLTLSGGQNLLLKLDYKNIDGTRSKVIRIYSPYIIMNSTDRELYIQSSLLNIAQSKILLEN
SQ  EKRYTIPKMFSFDKEDDKSNRARIRFKESEWSSKLSFDAIGQSFDASVRIKNKEQESNLGINISEGKGKYLLSKVIEIAP
SQ  RYIISNTLDIPIEVCETGSMDVQQIESNITKPLYRMRNIVDKQLVLKFLGGDSNWSQPFFIKNVGVTYLKVLKNSRHKLL
SQ  KIEILLDKATIFIRIKDGGDRWPFSIRNFSDHDFIFYQRDPRKVSDPYKDDQSNESSSRSFKPIFYRIPSKSIMPYAWDF
SQ  PTAKEKYLVLESGTRTREVRLAEIGELPPLRLDKRSKDKPAPIVGLHVVADDDMQALVIVNYKANVGLYKLKTASATTTS
SQ  SVSVNSSVTDGFVQKDEDEKVNTQIVVSFKGVGISLINGRLQELLYINMRGIELRYNESKAYQTFSWKMKWMQIDNQLFS
SQ  GNYSNILYPTEIPYTEKEIENHPVISGSISKVNDSLQAVPYFKHVTLLIQEFSIQLDEDMLYAMMDFIKFPGSPWIMDSR
SQ  DYKYDEEIQLPDVSELKTAGDIYFEIFHIQPTVLHLSFIRSDEISPGLAEETEESFSSSLYYVHMFAMTLGNINEAPVKV
SQ  NSLFMDNVRVPLPILMDHIERHYTTQFVYQIHKILGSADCFGNPVGLFNTISSGVWDLFYEPYQGYMMNDRPQEIGIHLA
SQ  KGGLSFAKKTVFGLSDSMSKFTGSMAKGLSVTQDLEFQRVRRLQQRINKNNRNALANSAQSFASTLGSGLSGIALDPYKA
SQ  MQKEGAAGFLKGLGKGIVGLPTKTAIGFLDLTSNLSQGVKSTTTVLDMQKGCRVRLPRYVDHDQIIKPYDLREAQGQYWL
SQ  KTVNGGVFMNDEYLSHVILPGKELAVIVSMQHIAEVQMATQELMWSTGYPSIQGITLERSGLQIKLKSQSEYFIPISDPE
SQ  ERRSLYRNIAIAVREYNKYCEAIL
//