ID  Q07912;
PN  Activated CDC42 kinase 1;
GN  TNK2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20979614}. Nucleus {ECO:0000269|PubMed:14733946, ECO:0000269|PubMed:20333297}. Endosome {ECO:0000250|UniProtKB:O54967}. Cell junction, adherens junction {ECO:0000305}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:16137687}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16137687, ECO:0000269|PubMed:18262180}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:21169560}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20110370}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O54967}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity). Co-localizes with EGFR on endosomes (PubMed:20333297). Nuclear translocation is CDC42-dependent (By similarity). Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity). {ECO:0000250|UniProtKB:O54967, ECO:0000269|PubMed:20333297}.
DR  UNIPROT: Q07912;
DR  UNIPROT: Q6ZMQ0;
DR  UNIPROT: Q8N6U7;
DR  UNIPROT: Q96H59;
DR  PDB: 1CF4;
DR  PDB: 1U46;
DR  PDB: 1U4D;
DR  PDB: 1U54;
DR  PDB: 3EQP;
DR  PDB: 3EQR;
DR  PDB: 4EWH;
DR  PDB: 4HZR;
DR  PDB: 4HZS;
DR  PDB: 4ID7;
DR  PDB: 5ZXB;
DR  PDB: 6VQM;
DR  PDB: 7KP6;
DR  Pfam: PF09027;
DR  Pfam: PF11555;
DR  Pfam: PF07714;
DR  Pfam: PF14604;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00109;
DR  PROSITE: PS50002;
DR  OMIM: 606994;
DR  DisGeNET: 10188;
DE  Function: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.
DE  Reference Proteome: Yes;
DE  Interaction: O14976; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O43426; IntAct: EBI-7809036; Score: 0.27
DE  Interaction: P00533; IntAct: EBI-702075; Score: 0.35
DE  Interaction: P60953; IntAct: EBI-603486; Score: 0.59
DE  Interaction: Q9Y5X1; IntAct: EBI-7808593; Score: 0.54
DE  Interaction: P62993; IntAct: EBI-7808665; Score: 0.66
DE  Interaction: P16333; IntAct: EBI-7808721; Score: 0.59
DE  Interaction: Q00610; IntAct: EBI-7808962; Score: 0.79
DE  Interaction: P51690; IntAct: EBI-736241; Score: 0.00
DE  Interaction: Q969R8; IntAct: EBI-736244; Score: 0.00
DE  Interaction: Q8N431; IntAct: EBI-736247; Score: 0.00
DE  Interaction: Q02543; IntAct: EBI-736250; Score: 0.00
DE  Interaction: Q53EL9; IntAct: EBI-736253; Score: 0.00
DE  Interaction: Q13243; IntAct: EBI-736256; Score: 0.00
DE  Interaction: Q9UEU0; IntAct: EBI-736259; Score: 0.00
DE  Interaction: P08575; IntAct: EBI-2257200; Score: 0.00
DE  Interaction: Q12913; IntAct: EBI-2265049; Score: 0.00
DE  Interaction: Q05209; IntAct: EBI-2266438; Score: 0.00
DE  Interaction: P56945; IntAct: EBI-7040520; Score: 0.52
DE  Interaction: P46108; IntAct: EBI-7040708; Score: 0.40
DE  Interaction: Q07912; IntAct: EBI-8071904; Score: 0.59
DE  Interaction: Q13177; IntAct: EBI-8143865; Score: 0.44
DE  Interaction: Q8IUQ4; IntAct: EBI-3934992; Score: 0.37
DE  Interaction: P08238; IntAct: EBI-6424981; Score: 0.56
DE  Interaction: Q8WXH5; IntAct: EBI-10692509; Score: 0.49
DE  Interaction: Q96JZ2; IntAct: EBI-10697958; Score: 0.37
DE  Interaction: O60880; IntAct: EBI-10187478; Score: 0.56
DE  Interaction: P07902; IntAct: EBI-10195306; Score: 0.56
DE  Interaction: P29972; IntAct: EBI-10205037; Score: 0.56
DE  Interaction: Q7Z3S9; IntAct: EBI-10224749; Score: 0.56
DE  Interaction: Q9HC98; IntAct: EBI-10310684; Score: 0.56
DE  Interaction: G3X972; IntAct: EBI-11079358; Score: 0.35
DE  Interaction: Q9NYZ3; IntAct: EBI-11081743; Score: 0.35
DE  Interaction: O95817; IntAct: EBI-11135110; Score: 0.35
DE  Interaction: Q9BQC3; IntAct: EBI-24322875; Score: 0.56
DE  Interaction: A8MQ03; IntAct: EBI-24423586; Score: 0.56
DE  Interaction: O14796; IntAct: EBI-24542932; Score: 0.56
DE  Interaction: Q92569; IntAct: EBI-24656100; Score: 0.56
DE  Interaction: O43639; IntAct: EBI-21521290; Score: 0.35
DE  Interaction: Q58FF7; IntAct: EBI-21831391; Score: 0.35
DE  Interaction: Q16543; IntAct: EBI-21831391; Score: 0.35
DE  Interaction: P05161; IntAct: EBI-21831391; Score: 0.35
DE  Interaction: P10275; IntAct: EBI-15636365; Score: 0.40
DE  Interaction: P16749; IntAct: EBI-15832981; Score: 0.41
DE  Interaction: Q01968; IntAct: EBI-16412116; Score: 0.35
DE  Interaction: P85968; IntAct: EBI-22241111; Score: 0.35
DE  Interaction: B2RZ33; IntAct: EBI-22241111; Score: 0.35
DE  Interaction: D4A3M8; IntAct: EBI-22241111; Score: 0.35
DE  Interaction: P97573; IntAct: EBI-22241127; Score: 0.35
DE  Interaction: O35244; IntAct: EBI-22241127; Score: 0.35
DE  Interaction: Q6UY14; IntAct: EBI-22141818; Score: 0.37
DE  Interaction: Q7Z7F7; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P07900; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P10809; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P17987; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P40227; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P48643; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P50991; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P78371; IntAct: EBI-25377008; Score: 0.35
DE  Interaction: P05141; IntAct: EBI-25388582; Score: 0.35
DE  Interaction: P49368; IntAct: EBI-25388582; Score: 0.35
DE  Interaction: P49411; IntAct: EBI-25388582; Score: 0.35
DE  Interaction: P50990; IntAct: EBI-25388582; Score: 0.35
DE  Interaction: Q58FF8; IntAct: EBI-25388582; Score: 0.35
DE  Interaction: O43264; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: Q9Y262; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: Q9BZD4; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: Q2NL82; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: Q13330; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: P56134; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: P25205; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: O15075; IntAct: EBI-28939183; Score: 0.35
DE  Interaction: P46937; IntAct: EBI-30846635; Score: 0.44
DE  Interaction: P07947; IntAct: EBI-30849214; Score: 0.44
GO  GO:0005912;
GO  GO:0005905;
GO  GO:0030136;
GO  GO:0097268;
GO  GO:0005737;
GO  GO:0030659;
GO  GO:0005829;
GO  GO:0005768;
GO  GO:0031234;
GO  GO:0070436;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005524;
GO  GO:0005154;
GO  GO:0005095;
GO  GO:0042802;
GO  GO:0046872;
GO  GO:0004715;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0004712;
GO  GO:0004713;
GO  GO:0005102;
GO  GO:0031625;
GO  GO:0050699;
GO  GO:0030154;
GO  GO:0007166;
GO  GO:0006897;
GO  GO:0045087;
GO  GO:0016310;
GO  GO:0050731;
GO  GO:2000369;
GO  GO:0007264;
GO  GO:0007169;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVF
SQ  SGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCL
SQ  KPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
SQ  GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTL
SQ  WEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFE
SQ  EPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
SQ  RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKA
SQ  SRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQ
SQ  DEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
SQ  PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGS
SQ  SPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQ
SQ  SPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
SQ  KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR
//