ID  Q07937;
PN  Nanos homolog 1;
GN  nanos1;
OS  8355;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21195170}. Note=During early cleavage and blastula stages found close to the cell periphery in a germ plasm-like pattern. From gastrula stage on, detected predominantly in a perinuclear region.
DR  UNIPROT: Q07937;
DR  Pfam: PF05741;
DR  PROSITE: PS51522;
DE  Function: Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES- driven, polyadenylated RNAs or nonpolyadenylated RNAs. Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival. {ECO:0000269|PubMed:21195170}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9DEB9; IntAct: EBI-7812774; Score: 0.54
GO  GO:0005737;
GO  GO:0060293;
GO  GO:0048471;
GO  GO:0003723;
GO  GO:0030371;
GO  GO:0008270;
GO  GO:0007281;
GO  GO:0008354;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDGGLCFDSWSDYLGLSSLISRGLQPQREGERPRWDVLSPASAEPLPSNESVGHKGCGFCRSNREALSLYTSHRLRALDG
SQ  RVLCPVLRGYTCPLCGANGDWAHTMRYCPLRRLLRDPQSNSNNPKLRH
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