ID  Q08231;
PN  Nuclear mRNA export protein THP1;
GN  THP1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus envelope {ECO:0000269|PubMed:12206772, ECO:0000269|PubMed:12411502, ECO:0000269|PubMed:14562095}. Note=Localizes to the nuclear pores.
DR  UNIPROT: Q08231;
DR  UNIPROT: D6W1Z5;
DR  PDB: 3T5V;
DR  PDB: 4TRQ;
DR  PDB: 5G5P;
DR  PDB: 5L3T;
DR  PDB: 5UBP;
DR  Pfam: PF01399;
DR  PROSITE: PS50250;
DE  Function: Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro. {ECO:0000269|PubMed:11139493, ECO:0000269|PubMed:12411502, ECO:0000269|PubMed:12702719}.
DE  Reference Proteome: Yes;
DE  Interaction: P06704; IntAct: EBI-1370592; Score: 0.76
DE  Interaction: P46674; IntAct: EBI-797734; Score: 0.88
DE  Interaction: P21576; IntAct: EBI-797734; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-7081522; Score: 0.40
DE  Interaction: Q02804; IntAct: EBI-8230453; Score: 0.22
DE  Interaction: Q6WNK7; IntAct: EBI-1370393; Score: 0.78
DE  Interaction: Q02336; IntAct: EBI-1370467; Score: 0.50
DE  Interaction: P53040; IntAct: EBI-1370499; Score: 0.35
DE  Interaction: Q03761; IntAct: EBI-1370619; Score: 0.35
DE  Interaction: P50875; IntAct: EBI-1370619; Score: 0.35
DE  Interaction: P38811; IntAct: EBI-2124399; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3678586; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3697051; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3716418; Score: 0.35
DE  Interaction: Q05931; IntAct: EBI-3720118; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3722302; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3730594; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3747715; Score: 0.35
DE  Interaction: O94742; IntAct: EBI-15970396; Score: 0.50
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0070390;
GO  GO:0003690;
GO  GO:0044877;
GO  GO:0003723;
GO  GO:0000282;
GO  GO:0031124;
GO  GO:0006406;
GO  GO:0071028;
GO  GO:0016973;
GO  GO:0045944;
GO  GO:0000973;
GO  GO:0006368;
GO  GO:0006283;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDMANQLLDELAHGNFSHLTLNLSQNGREIAILQKQLTGFDDKQLETFVEQHPAMPNDTRFKIMCTSFLNYARDVDPWSA
SQ  WSSSDLIFEFYQCLINCLINDNAPHIEMLIPVATRETEFIINLAGKLDSFHLQLHTRSHQFLSHISSILSRLFNSIKPPR
SQ  GNASSTNIPGKQRILLYLVNKLNNIYFRIESPQLCSNIFKNFQPKSMLAHFNEYQLDQQIEYRYLLGRYYLLNSQVHNAF
SQ  VQFNEAFQSLLNLPLTNQAITRNGTRILNYMIPTGLILGKMVKWGPLRPFLSQETIDNWSVLYKHVRYGNIQGVSLWLRQ
SQ  NERHLCARQLLIVLLEKLPMVTYRNLIKTVIKSWTTEWGQNKLPYSLIERVLQLSIGPTFEDPGAQEITIYNGIHSPKNV
SQ  ENVLVTLINLGLLRANCFPQLQLCVVKKTTMIQEIVPPVNERITKMFPAHSHVLW
//