ID  Q08DP6;
PN  Rho GTPase-activating protein 10;
GN  ARHGAP10;
OS  9913;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}.
DR  UNIPROT: Q08DP6;
DR  Pfam: PF00169;
DR  Pfam: PF00620;
DR  Pfam: PF14604;
DR  PROSITE: PS50003;
DR  PROSITE: PS50238;
DR  PROSITE: PS50002;
DE  Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005096;
GO  GO:0007010;
GO  GO:0043066;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKTLSAAQRKFAHSLRDFKFEFIGDAETDDE
SQ  RCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETERNYSLIDKHLNLSAKKKDSHL
SQ  QEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE
SQ  GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPPPFGSSWVKHYCMYRKAAKKFTMIPFEHRSGGKLGDGEVFF
SQ  LKECIRRHTDSIDRRFCFDVEAADRPGISLTMQAFSEEERKQWLEVLGGKEALFPSFNRAIIPRPEGSAQLDKMGFTILR
SQ  KCIRAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSVDWEVKTITSALKQYLRSLPEPLMTYELHGDFI
SQ  VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQN
SQ  IVVEILIENHEKIFRTPPDATLPEPGPLSAPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDRPSLPKEDTPPSSLDSL
SQ  SSPSPTTATALGHPGPDRNHLLTDGGSFGDWAPTAPSQARSSAVQWLNPQSPTTPSCSPAVTPPSPKLPPVPLSLPATVA
SQ  DKPPESIISRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
//