ID  Q0VC89;
PN  Palmitoyltransferase ZDHHC20;
GN  ZDHHC20;
OS  9913;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5W0Z9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5W0Z9}. Cell membrane {ECO:0000250|UniProtKB:Q5W0Z9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5W0Z9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q5W0Z9}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5W0Z9}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q5W0Z9}; Multi-pass membrane protein {ECO:0000255}.
DR  UNIPROT: Q0VC89;
DR  Pfam: PF01529;
DR  PROSITE: PS50216;
DE  Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. {ECO:0000250|UniProtKB:Q5W0Z9}.
DE  Reference Proteome: Yes;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0033116;
GO  GO:0005794;
GO  GO:0030173;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0019705;
GO  GO:0019706;
GO  GO:0140439;
GO  GO:0008270;
GO  GO:0018230;
GO  GO:0018345;
GO  GO:0006612;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q5W0Z9};
SQ  MAPCTLWRCCQRTVGWVPVLFITFVVVWSYYAYVVELCVFTLSGNGENGKAVVYLVAFHLFFVMFVWSYWMTIFTSPASP
SQ  SKEFCLSNSEKERYEKEFSQERQQEILRRAARDLPIYTTSASKTVRYCERCQLIKPDRAHHCSACDMCILKMDHHCPWVN
SQ  NCVGFSNYKFFLLFLFYSLLYCLFVATTVLQYFIKFWTNELTDTRAKFHVLFLFFVSTMFFISVLSLLSYHCWLVGKNRT
SQ  TIESFRAPMFSYGTDGNGFSLGCSKNWRQVFGDEKKYWLLPVFSSQGDGCSFPTRLVGTDPEQASVSNQSESARSIGSNQ
SQ  PFPIKPLSESKNRLLDSDPQWLESGSEEGVGGSGTNNHVTVAIEN
//