ID  Q10109;
PN  Lap-Emerin-Man domain protein 2;
GN  lem2;
OS  284812;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18692466}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18692466}.
DR  UNIPROT: Q10109;
DR  PDB: 5YCA;
DR  Pfam: PF12949;
DR  Pfam: PF09402;
DE  Function: Nucleus inner membrane protein involved in meiosis (PubMed:20404563). Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis (PubMed:28242692). {ECO:0000269|PubMed:20404563, ECO:0000269|PubMed:28242692}.
DE  Reference Proteome: Yes;
GO  GO:0061638;
GO  GO:0034506;
GO  GO:0099115;
GO  GO:0005639;
GO  GO:0140599;
GO  GO:0044732;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005721;
GO  GO:0097038;
GO  GO:0033553;
GO  GO:0140449;
GO  GO:0019237;
GO  GO:0003682;
GO  GO:0003690;
GO  GO:0062239;
GO  GO:0140698;
GO  GO:0072766;
GO  GO:0070828;
GO  GO:0051321;
GO  GO:0007084;
GO  GO:0071765;
GO  GO:0071763;
GO  GO:0140462;
GO  GO:0097355;
GO  GO:0140464;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDNWEDPNFELRNLRVIDLKKILHESGVSFPVNARKIEYIRMVDRIRKNKLSSGPQHLLSHLQKEENSNTSKASSSEDEI
SQ  APKYLYPSSPSKSTKKPHNETEPLLSPQFIDKPSNIETPVKIESPHVSQNNTFQSYSELSPNVETSLTMKTPPAHASTPK
SQ  FRSHKSHRVAVPMSFMDSSALHTSPAFSERLKLLSSSNNFSPQLRSPKISHRLQTSATSSPLQHKRPFTNVPERVSRDIE
SQ  FAPLDSARPSESSSPYSEVDSAEEDDELFQNYVLQQTRKESKLWSFIKKVFHDIKYANYRLLHNLRAFPGISAISSSYLV
SQ  HIFMILLGVVAAIFLALLREKMFTAGFCDSGASGSSASILGISFPSLCRTCPPNAICPSPNYVECKPGYVLYEPWYSSLG
SQ  FWPSKYCVSDTSREESVNIFREECLSVLRSWNAILHCSNNSSDLLERNMSYNAHPYVADNLNISSDHISFPSKPFALGLL
SQ  HDTLLERKSPTLGLEMFEDLFKASLAVLSETNEVVMDSKLICYDSWAGIPLRCRLKQQLIKFVWRNKVFLFGILALSGVI
SQ  FKLINFFRTRSIVAKYLPSASRFCVESLKRQKANYQMSRSQEPVIPLIEMHDILFHGNGPLEQIHMTKATARTLWEAIVE
SQ  RVEQVGSVRTRESEVDGEWTRVWEWVGTNTLDFQTDRSFINTTSPLRE
//